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COPS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626420

COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. This protein phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
COPS3, Polyclonal Antibody
Full Product Name
COPS3, ID (COP9 Signalosome Complex Subunit 3, Signalosome Subunit 3, SGN3, JAB1-containing Signalosome Subunit 3, CSN3)
Product Gene Name
anti-COPS3 antibody
Product Synonym Names
Anti -COPS3, ID (COP9 Signalosome Complex Subunit 3, Signalosome Subunit 3, SGN3, JAB1-containing Signalosome Subunit 3, CSN3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human COPS3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
47,873 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (17150139..17184591, complement). Location: 17p11.2
OMIM
604665
3D Structure
ModBase 3D Structure for Q9UNS2
Immunogen
Synthetic peptide selected from the Center region of human COPS3 (KLH).

Product Categories/Family for anti-COPS3 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-COPS3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-COPS3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-COPS3 antibody

Western blot analysis of COPS3 Antibody (Center) in Jurkat, 293 cell line lysates (35ug/lane). COPS3 (arrow) was detected using the purified Pab.
Rabbit Anti-COPS3 Polyclonal Antibody – Cat# MBS626420

Western Blot (WB) of anti-COPS3 antibody

Western blot analysis of COPS3 (arrow) using rabbit polyclonal COPS3 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COPS3 gene.
Rabbit Anti-COPS3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS626420

Other Notes

Small volumes of anti-COPS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPS3 purchase

MBS626420 is an antibody targeting COPS3. Also known as COPS3, ID (COP9 Signalosome Complex Subunit 3, Signalosome Subunit 3, SGN3, JAB1-containing Signalosome Subunit 3, CSN3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COPS3. It may not necessarily be applicable to this product.

NCBI GI #
312284090
NCBI GeneID
8533
NCBI Accession #
NP_001186054.1
UniProt Primary Accession #
Q9UNS2
UniProt Secondary Accession #
O43191; Q7LDR6; B2R683
UniProt Related Accession #
Q9UNS2
GenBank Nucleotide #
NM_001199125.1
NCBI Official Full Name
COP9 signalosome complex subunit 3 isoform 2
NCBI Official Synonym Full Names
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
NCBI Official Symbol
COPS3
NCBI Official Synonym Symbols
CSN3; SGN3
UniProt Protein Name
COP9 signalosome complex subunit 3
UniProt Synonym Protein Names
JAB1-containing signalosome subunit 3
UniProt Gene Name
COPS3
UniProt Synonym Gene Names
CSN3
UniProt Entry Name
CSN3_HUMAN
NCBI Protein Information
COP9 signalosome complex subunit 3; OTTHUMP00000065517; signalosome subunit 3; COP9 complex subunit 3; JAB1-containing signalosome subunit 3

NCBI Summary for COPS3

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for COPS3

COPS3: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; signalosome; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: ubiquitin-dependent protein catabolic process; response to light stimulus; cullin deneddylation; in utero embryonic development; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COPS3 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >3 publications with COPS3 and TP53

Pathways associated with anti-COPS3 antibody

 Products by Pathway  Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-COPS3 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with COPS3 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with COPS3 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >1 publications with COPS3 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >1 publications with COPS3 and Carcinoma
 Congenital Abnormalities Antibodies  >1 publications with COPS3 and Congenital Abnormalities
 Multiple Myeloma Antibodies  >1 publications with COPS3 and Multiple Myeloma
 Neoplasms, Experimental Antibodies  >1 publications with COPS3 and Neoplasms, Experimental
 Carcinoma, Lewis Lung Antibodies  >1 publications with COPS3 and Carcinoma, Lewis Lung

Organs/Tissues associated with anti-COPS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with COPS3 and Bone
 Bone Marrow Antibodies  >1 publications with COPS3 and Bone Marrow
 Lung Antibodies  >1 publications with COPS3 and Lung
 Testis Antibodies  >1 publications with COPS3 and Testis
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