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PSMD7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626584

PSMD7 acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
PSMD7, Polyclonal Antibody
Full Product Name
PSMD7, NT (26S Proteasome Non-ATPase Regulatory Subunit 7, 26S Proteasome Regulatory Subunit RPN8, 26S Proteasome Regulatory Subunit S12, Proteasome Subunit p40, Mov34 Protein Homolog, MOV34L)
Product Gene Name
anti-PSMD7 antibody
Product Synonym Names
Anti -PSMD7, NT (26S Proteasome Non-ATPase Regulatory Subunit 7, 26S Proteasome Regulatory Subunit RPN8, 26S Proteasome Regulatory Subunit S12, Proteasome Subunit p40, Mov34 Protein Homolog, MOV34L)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.101% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PSMD7.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,025 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (74330681..74340186). Location: 16q22.3
OMIM
157970
3D Structure
ModBase 3D Structure for P51665
Immunogen
Synthetic peptide selected from the N-terminal region of human PSMD7 (KLH).

Product Categories/Family for anti-PSMD7 antibody

Antibodies; Abs to Proteasomes
Applications Tested/Suitable for anti-PSMD7 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PSMD7 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PSMD7 antibody

Western blot analysis of PSMD7 Antibody (N-term) in A375 cell line lysates (35ug/lane). PSMD7 (arrow) was detected using the purified Pab.
Rabbit Anti-PSMD7 Polyclonal Antibody – Cat# MBS626584

Immunohistochemistry (IHC) of anti-PSMD7 antibody

Formalin-fixed and paraffin-embedded human skin tissue reacted with PSMD7 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PSMD7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS626584

Flow Cytometry (FC/FACS) of anti-PSMD7 antibody

PSMD7 Antibody (N-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PSMD7 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS626584

Other Notes

Small volumes of anti-PSMD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMD7 purchase

MBS626584 is an antibody targeting PSMD7. Also known as PSMD7, NT (26S Proteasome Non-ATPase Regulatory Subunit 7, 26S Proteasome Regulatory Subunit RPN8, 26S Proteasome Regulatory Subunit S12, Proteasome Subunit p40, Mov34 Protein Homolog, MOV34L). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMD7. It may not necessarily be applicable to this product.

NCBI GI #
33875323
NCBI GeneID
5713
UniProt Primary Accession #
P51665
UniProt Secondary Accession #
Q6PKI2; Q96E97; D3DWS9
UniProt Related Accession #
P51665
NCBI Official Full Name
PSMD7 protein
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
NCBI Official Symbol
PSMD7
NCBI Official Synonym Symbols
P40; S12; Rpn8; MOV34
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 7
UniProt Synonym Protein Names
26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein homolog; Proteasome subunit p40
Protein Family
26S proteasome non-ATPase regulatory
UniProt Gene Name
PSMD7
UniProt Synonym Gene Names
MOV34L
UniProt Entry Name
PSD7_HUMAN
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 7; Mov34 homolog; OTTHUMP00000174936; proteasome subunit p40; 26S proteasome regulatory subunit S12; 26S proteasome regulatory subunit rpn8; Moloney leukemia virus-34 proviral integration; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)

NCBI Summary for PSMD7

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq]
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UniProt Comments for PSMD7

PSMD7: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family.

Protein type: Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 16q22.3

Cellular Component: proteasome complex; nucleoplasm; membrane; proteasome regulatory particle; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
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Research Articles on PSMD7

1. SNP rs17336700 of a non-MHC ubiquitin-proteasome subunit PSMD7 is significantly associated with ankylosing spondylitis in Chinese population and the mRNA level of the PSMD7 gene in liver tissue increased when the rs17336700 C allele was present.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSMD7 antibody

 Reference Product  PubMed Publications
 VIM antibody  >1 publications with PSMD7 and VIM

Pathways associated with anti-PSMD7 antibody

 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Autodegradation Of Cdh1 By Cdh1:APC/C Pathway antibodies  Autodegradation Of Cdh1 By Cdh1:APC/C Pathway Diagram

Diseases associated with anti-PSMD7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with PSMD7 and Neoplasms
 Breast Neoplasms Antibodies  >3 publications with PSMD7 and Breast Neoplasms
 Leukemia Antibodies  >1 publications with PSMD7 and Leukemia
 Female Urogenital Diseases Antibodies  >1 publications with PSMD7 and Female Urogenital Diseases
 Lung Diseases Antibodies  >1 publications with PSMD7 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with PSMD7 and Lung Neoplasms
 Brain Neoplasms Antibodies  >1 publications with PSMD7 and Brain Neoplasms
 Central Nervous System Diseases Antibodies  >1 publications with PSMD7 and Central Nervous System Diseases
 Gonadal Disorders Antibodies  >1 publications with PSMD7 and Gonadal Disorders
 Bone Marrow Neoplasms Antibodies  >1 publications with PSMD7 and Bone Marrow Neoplasms

Organs/Tissues associated with anti-PSMD7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with PSMD7 and Brain
 Bone Marrow Antibodies  >1 publications with PSMD7 and Bone Marrow
 Blood Antibodies  >1 publications with PSMD7 and Blood
 Bone Antibodies  >1 publications with PSMD7 and Bone
 Lung Antibodies  >1 publications with PSMD7 and Lung
 Ovary Antibodies  >1 publications with PSMD7 and Ovary
 Embryonic Tissue Antibodies  >1 publications with PSMD7 and Embryonic Tissue
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