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STAT6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601877

Description: STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4.Function: Carries out a dual signal… More details

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Product Overview

Online Datasheet in PDF
Product Name
STAT6, Polyclonal Antibody
Full Product Name
STAT6 Antibody
Product Gene Name
anti-STAT6 antibody
Product Synonym Names
12S1644; D12S1644; IL 4 STAT; IL-4 Stat; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; Signal transducer and activator of transcription 6, interleukin 4 induced; STAT 6; STAT interleukin4 induced; STAT, interleukin4 induced; Stat6; STAT6_HUMAN; STAT6B; STAT6C; Transcription factor IL 4 STAT
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
STAT6 antibody detects endogenous levels of total STAT6
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
STAT6 peptide (MBS9617429) is used for blocking the activity of STAT6 antibody (MBS9601877)
Molecular Weight
Observed: 94 kDa
Predicted: 95 kDa
3D Structure
ModBase 3D Structure for P42226
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human STAT6
Subcellular Location
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Predicted Cross Reactivity
Pig, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-STAT6 antibody
Western Blot (WB), Immunohistochemisty (IHC), Immunoflurescene (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), ELISA (EIA)
Application Notes for anti-STAT6 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-STAT6 antibody

Western blot analysis of STAT6 expression in HeLa whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-STAT6 Polyclonal Antibody – Cat# MBS9601877

Immunofluorescene (IF) of anti-STAT6 antibody

MBS9601877 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-STAT6 Polyclonal Antibody, Immunofluorescene (IF) – Cat# MBS9601877

Immunohistochemistry (IHC) of anti-STAT6 antibody

MBS9601877 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-STAT6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9601877

Other Notes

Small volumes of anti-STAT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT6 purchase

MBS9601877 is an antibody targeting STAT6. Also known as STAT6 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT6. It may not necessarily be applicable to this product.

NCBI GI #
296010864
NCBI GeneID
6778
NCBI Accession #
NP_001171549.1
UniProt Primary Accession #
P42226
UniProt Secondary Accession #
Q5FBW5; Q71UP4; A8K316; B7ZA27; F5GXI9
UniProt Related Accession #
P42226
GenBank Nucleotide #
NM_001178078.1
NCBI Official Full Name
signal transducer and activator of transcription 6 isoform 1
NCBI Official Synonym Full Names
signal transducer and activator of transcription 6
NCBI Official Symbol
STAT6
NCBI Official Synonym Symbols
STAT6B; STAT6C; D12S1644; IL-4-STAT
UniProt Protein Name
Signal transducer and activator of transcription 6
UniProt Synonym Protein Names
IL-4 Stat
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
STAT6
NCBI Protein Information
signal transducer and activator of transcription 6

NCBI Summary for STAT6

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for STAT6

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Research Articles on STAT6

1. is a dependable marker to differentiate solitary fibrous tumors and myofibromas

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAT6 antibody

 Reference Product  PubMed Publications
 JAK1 antibody  >121 publications with STAT6 and JAK1
 STAT2 antibody  >53 publications with STAT6 and STAT2
 SRC antibody  >42 publications with STAT6 and SRC
 IL4R antibody  >23 publications with STAT6 and IL4R
 PTPN6 antibody  >17 publications with STAT6 and PTPN6
 NCOA1 antibody  >10 publications with STAT6 and NCOA1
 IRF4 antibody  >6 publications with STAT6 and IRF4
 CREBBP antibody  >5 publications with STAT6 and CREBBP
 SND1 antibody  >5 publications with STAT6 and SND1
 RELA antibody  >3 publications with STAT6 and RELA

Pathways associated with anti-STAT6 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-STAT6 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >362 publications with STAT6 and Inflammation
 Lung Diseases Antibodies  >242 publications with STAT6 and Lung Diseases
 Neoplasms Antibodies  >206 publications with STAT6 and Neoplasms
 Necrosis Antibodies  >138 publications with STAT6 and Necrosis
 Nervous System Diseases Antibodies  >59 publications with STAT6 and Nervous System Diseases
 Dermatitis, Atopic Antibodies  >53 publications with STAT6 and Dermatitis, Atopic
 Cardiovascular Diseases Antibodies  >45 publications with STAT6 and Cardiovascular Diseases
 Liver Diseases Antibodies  >43 publications with STAT6 and Liver Diseases
 Hyperplasia Antibodies  >39 publications with STAT6 and Hyperplasia
 Neoplasms, Experimental Antibodies  >38 publications with STAT6 and Neoplasms, Experimental

Organs/Tissues associated with anti-STAT6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >967 publications with STAT6 and Blood
 Lung Antibodies  >267 publications with STAT6 and Lung
 Bone Antibodies  >107 publications with STAT6 and Bone
 Spleen Antibodies  >97 publications with STAT6 and Spleen
 Bone Marrow Antibodies  >91 publications with STAT6 and Bone Marrow
 Intestine Antibodies  >90 publications with STAT6 and Intestine
 Muscle Antibodies  >90 publications with STAT6 and Muscle
 Liver Antibodies  >88 publications with STAT6 and Liver
 Skin Antibodies  >76 publications with STAT6 and Skin
 Lymph Node Antibodies  >67 publications with STAT6 and Lymph Node
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