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Hypoxia Inducible Factor 1a (HIF-1a) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6266904

MBS6266904 is an antibody targeting HIF-1a. Also known as Hypoxia Inducible Factor 1a (HIF-1a) (BSA & Azide Free) (PE). Reactive in Ferret Human, Mouse, Rat, Sheep. Host: Mouse. More details

$1055 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Hypoxia Inducible Factor 1a (HIF-1a), Monoclonal Antibody
Full Product Name
Hypoxia Inducible Factor 1a (HIF-1a) (BSA & Azide Free) (PE)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
0.N.329
Host
Mouse
Species Reactivity
Ferret Human, Mouse, Rat, Sheep
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes the alpha subunit of HIF-1 at 120kD. Species crossreactivity: Human, sheep, mouse, rat and ferret.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Immunogen
Recombinant protein corresponding to residues 432-528 of hHIF-1a.
Conjugate
PE
Applications Tested/Suitable for anti-HIF-1a antibody
Immunohistochemistry (IHC)

Product References and Citations for anti-HIF-1a antibody

1. Semenza, GL, Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. J. Lab Clinical Medicine. 131: 207-214, 1998. 2. Iyer, NV, et al. Cellular and developmental control of 02 homeostasis by hypoxia-inducible factor alpha. Genes and Development. 12(2): 149-162, 1998. 3. Flamme I; Frohlich T; von Reutern M; Kappel A; Damert A; Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mechanisms of Development, 1997, 63(1):51-60. 4. Gassmann M; Kvietikova I; Rolfs A; Wenger RH. Oxygen-and dioxin-regulated gene expression in mouse hepatoma cells. Kidney International, 1997 Feb, 51(2):567-74. 5. Huang LE; Ho V; Arany Z; Krainc D; Galson D; Tendler D; Livingston DM; Bunn HF. Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney International, 1997 Feb, 51(2):548-52. 6. Jelkmann W; Pagel H; Hellwig T; Fandrey J. Effects of antioxidant vitamins on renal and hepatic erythropoietin production. Kidney International, 1997 Feb, 51(2):497-501. 7. Pugh CW; O'Rourke JF; Nagao M; Gleadle JM; Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. Journal of Biological Chemistry, 1997, 272(17):11205-14. 8. Semenza GL; Agani F; Booth G; Forsythe J; Iyer N; Jiang BH; Leung S; Roe R; Wiener C; Yu A. Structural and functional analysis of hypoxia-inducible factor 1. Kidney International, 1997, 51(2):553-5. 9. Wenger RH; Kvietikova I; Rolfs A; Gassmann M; Marti HH. Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level. Kidney International, 1997 Feb, 51(2):560-3. 10. Arany Z; Huang LE; Eckner R; Bhattacharya S; Jiang C; Goldberg MA; Bunn HF; Livingston DM. An essential role for p300/CBP in the cellular response to hypoxia. Proceedings of the National Academy of Sciences of the United States of America, 1996 Nov 12, 93(23):12969-73.

Other Notes

Small volumes of anti-HIF-1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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