Goat Anti-PROK2 Polyclonal Antibody – Cat# MBS626696

Prokineticin 2 (PROK2) Antibody – Goat Polyclonal

Name: PROK2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS626696
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626696

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor… More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Prokineticin 2 (Prok2), Polyclonal Antibody

Full Product Name

Prokineticin 2 (Prokineticin-2, PK2, PROK2, PK2, Protein Bv8 homolog, PROK2, BV8)

Product Gene Name

anti-Prok2 antibody

Product Synonym Names

Anti -Prokineticin 2 (Prokineticin-2, PK2, PROK2, PK2, Protein Bv8 homolog, PROK2, BV8)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by peptide affinity chromatography.

Specificity

Recognizes Prokineticin 2. Expected to recognize isoform a (NP_001119600.1). Species sequence homology: human.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

11,594 Da

Chromosome Location

Chromosome: 4; NC_005103.2 (134561300..134574487, complement). Location: 4q34

3D Structure

ModBase 3D Structure for Q8R413

Immunogen

Synthetic peptide corresponding to C-HPLTRKNNFGNGRQE, from the internal region of human Prokineticin 2(NP_001119600.1).

Product Categories/Family for anti-Prok2 antibody

Antibodies; Abs to Angiogenesis

Applications Tested/Suitable for anti-Prok2 antibody

ELISA (EL/EIA)

Application Notes for anti-Prok2 antibody

Suitable for use in ELISA.
Dilution: Peptide ELISA Titer: 1:32,000

Other Notes

Small volumes of anti-Prok2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Prok2 purchase

MBS626696 is an antibody targeting Prok2. Also known as Prokineticin 2 (Prokineticin-2, PK2, PROK2, PK2, Protein Bv8 homolog, PROK2, BV8). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Prok2. It may not necessarily be applicable to this product.

NCBI GI #

20301998

NCBI GeneID

192206

NCBI Accession #

NP_620207.1

UniProt Primary Accession #

Q8R413

UniProt Related Accession #

Q6V8J7; Q8R413

GenBank Nucleotide #

NM_138852.1

NCBI Official Full Name

prokineticin-2 isoform 2

NCBI Official Synonym Full Names

prokineticin 2

NCBI Official Symbol

Prok2

NCBI Official Synonym Symbols

Bv8

UniProt Protein Name

Prokineticin-2

Protein Family

Prokineticin

UniProt Gene Name

Prok2

UniProt Synonym Gene Names

Bv8

UniProt Entry Name

PROK2_RAT

NCBI Protein Information

prokineticin-2; PK2; prokineticin 2 beta; homolog of mouse Bv8 (Bombina variegata 8 kDa); homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2

NCBI Summary for Prok2

ligand of of two orphan G-protein-coupled receptors designated ZAQ and I5E [RGD]

UniProt Comments for Prok2

Function: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle

Subcellular location: Secreted

Tissue specificity: Expressed at high levels in testis and at lower levels in brain, lung, ovary, spleen, thymus and uterus.

Induction: Activated by CLOCK and BMAL1 heterodimers and light; inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2)

Probable.

Sequence similarities: Belongs to the AVIT (prokineticin) family.

Research Articles on Prok2

1. PK2 down-regulates the function of the GABA(A) receptor via G-protein and protein kinase C dependent signal pathways in primary sensory neurons and this depression might underlie the hyperalgesia induced by PK2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Prok2 antibody

Products by Pathway	Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-Prok2 antibody

Disease Name	Pubmed Publications
Hypogonadism Antibodies	>36 publications with Prok2 and Hypogonadism
Kallmann Syndrome Antibodies	>35 publications with Prok2 and Kallmann Syndrome
Neurologic Manifestations Antibodies	>15 publications with Prok2 and Neurologic Manifestations
Inflammation Antibodies	>8 publications with Prok2 and Inflammation
Pain Antibodies	>7 publications with Prok2 and Pain
Hyperalgesia Antibodies	>6 publications with Prok2 and Hyperalgesia
Pancreatic Neoplasms Antibodies	>3 publications with Prok2 and Pancreatic Neoplasms
Obesity Antibodies	>3 publications with Prok2 and Obesity
Neurodegenerative Diseases Antibodies	>1 publications with Prok2 and Neurodegenerative Diseases
Liver Diseases Antibodies	>1 publications with Prok2 and Liver Diseases