Rabbit Anti-IL34 Polyclonal Antibody – Cat# MBS626769

Western blot analysis of IL-34 in human brain tissue lysate with IL-34 antibody at 0.25 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Interleukin 34, in (IL34) Antibody – Rabbit Polyclonal

Name: IL34 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS626769
Price: 850 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626769

Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival… More details

$850 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 34, IN (IL34), Polyclonal Antibody

Full Product Name

Interleukin 34, IN (IL-34, C16orf77, chromosome 16 open reading frame 77, hypothetical protein MGC34647, MGC34647)

Product Gene Name

anti-IL34 antibody

Product Synonym Names

Anti -Interleukin 34, IN (IL-34, C16orf77, chromosome 16 open reading frame 77, hypothetical protein MGC34647, MGC34647)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in PBS, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human IL-34. Species Crossreactivity: Mouse and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

27,482 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (70613798..70694585). Location: 16q22.1

OMIM

612081

3D Structure

ModBase 3D Structure for Q6ZMJ4

Immunogen

Synthetic peptide corresponding to 13aa from near the center of human IL-34.

Positive Control

Storage and Stability: Human Brain Tissue Lysate

Product Categories/Family for anti-IL34 antibody

Antibodies; Abs to Interleukin

Applications Tested/Suitable for anti-IL34 antibody

Western Blot (WB)

Application Notes for anti-IL34 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 0.25-0.5ug/ml

Other Notes

Small volumes of anti-IL34 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL34 purchase

MBS626769 is an antibody targeting IL34. Also known as Interleukin 34, IN (IL-34, C16orf77, chromosome 16 open reading frame 77, hypothetical protein MGC34647, MGC34647). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL34. It may not necessarily be applicable to this product.

NCBI GI #

289666752

NCBI GeneID

146433

NCBI Accession #

NP_001166243.1

UniProt Primary Accession #

Q6ZMJ4

UniProt Secondary Accession #

Q8N6L2; B2RC28; B2Z4A8; B2ZC70

UniProt Related Accession #

Q6ZMJ4

GenBank Nucleotide #

NM_001172772.1

NCBI Official Full Name

interleukin-34 isoform 1

NCBI Official Synonym Full Names

interleukin 34

NCBI Official Symbol

IL34

NCBI Official Synonym Symbols

IL-34; C16orf77; MGC34647

UniProt Protein Name

Interleukin-34

Protein Family

Interleukin

UniProt Gene Name

IL34

UniProt Synonym Gene Names

C16orf77

UniProt Entry Name

IL34_HUMAN

NCBI Protein Information

interleukin-34; OTTHUMP00000174906

NCBI Summary for IL34

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM]

UniProt Comments for IL34

IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of cell proliferation; innate immune response; positive regulation of protein amino acid phosphorylation; inflammatory response

Research Articles on IL34

1. The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-IL34 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1 publications with IL34 and Bone
Embryonic Tissue Antibodies	>1 publications with IL34 and Embryonic Tissue
Brain Antibodies	>1 publications with IL34 and Brain