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Chromogranin A (CHGA) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6267866

MBS6267866 is an antibody targeting CHGA. Also known as Chromogranin A, mixed clones (BSA & Azide Free) (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI) (MaxLight 650). Reactive in Human, Monkey.… More details

$1260 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Chromogranin A (CHGA), Monoclonal Antibody
Full Product Name
Chromogranin A, mixed clones (BSA & Azide Free) (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI) (MaxLight 650)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG1
Clone Number
LK2H10 + PHE5
Host
Mouse
Species Reactivity
Human, Monkey
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
The cocktail is especially designed for sensitive detection of Chromogranin A in formalin-fixed, paraffin-embedded tissues. Species Crossreactivity: human and monkey.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
50,688 Da
Immunogen
Human pheochromocytoma
Conjugate
MaxLight650

Product Categories/Family for anti-CHGA antibody

Applications Tested/Suitable for anti-CHGA antibody
Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-CHGA antibody

Formalin-fixed, paraffin-embedded human carcinoid stained with MBS602178 using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells.
Mouse Anti-CHGA Monoclonal Antibody – Cat# MBS6267866

Product References and Citations for anti-CHGA antibody

1. Lloyd RV, et. al. Science, 1983, 222:628-30. 2. Riddell K, et. al. Lab Invest 56:64A, 1987 Additional: 1. Battersby S; Dely CJ; Hopkinson HE; Anderson TJ. The nature of breast dense core granules: chromogranin reactivity. Histopathology, 1992, 20:107-14. 2. Lukinius A; Wilander E; Eriksson B; Oberg K. A chromogranin peptide is co-stored with insulin in the human pancreatic islet B-cell granules. Histochemical Journal, 1992 Sep, 24(9):679-84. 3. Wirnsberger GH; Becker H; Ziervogel K; Hofler H. Diagnostic immunohistochemistry of neuroblastic tumors. Am J of Surgical Pathology, 1992, 16:49-57. 4. Diepholder HM; Schwechheimer K; Mohadjer M; Knoth R; Volk B. A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma. Cancer, 1991, 68(10):2192- 201. 5. Kalina M; Grimelius L. Chromogranins or chromograninlike proteins are present in lamellar bodies and pulmonary surfactant of rat alveolar type II cells. Journal of Histochemistry and Cytochemistry, 1991 Feb, 39(2):213-20. 6. Munoz DG. Chromogranin A-like immunoreactive neurites are major constituents of senile plaques. Lab Investigation, 1991, 64:826-32. 7. Weihe E; Horsch D; Eiden LE; Hartschuh W. Dual presence of chromogranin A-like immunoreactivity in a population of endocrine-like cells and in nerve fibers in the human anal canal. Neuroscience Letters, 1991 Sep 16, 130(2):190-4. 8. Andreola S; Lombardi L; Audisio RA; Mazzaferro V; Koukouras D; Doci R; Gennari L; Makowka L; Starzl TE; van Thiel DH. A clinicopathologic study of primary hepatic carcinoid tumors. Cancer, 1990 Mar 1, 65(5):1211-8. 9. Becker H; Wirnsberger G; Ziervogel K; Hofler H. Immunohistochemical markers in (ganglio)neuroblastomas. Acta Histochemica. Supplementband, 1990, 38:107-14. 10. McAuliffe WG; Hess A. Human chromogranin A-like immunoreactivity in the Bergmann glia of the rat brain. Glia, 1990, 3(1):13-6. 11. Munoz DG; Kobylinski L; Henry DD; George DH. Chromogranin A-like immunoreactivity in the human brain: distribution in bulbar medulla and cerebral cortex. Neuroscience, 1990, 34(3):533-43. 12. Chang TK; Li CY; Smithson WA. Immunocytochemical study of small round cell tumors in routinely processed specimens. Archives of Pathol and Lab Medicine, 1989, 113:1343-8. 13. Hawkins KL; Lloyd RV; Toy KA. Immunohistochemical localization of chromogranin A in normal tissues from laboratory animals. Veterinary Pathology, 1989 Nov, 26(6):488-98. 14. Lloyd RV; Iacangelo A; Eiden LE; Cano M; Jin L; Grimes M. Chromogranin A and B messenger ribonucleic acids in pituitary and other normal and neoplastic human endocrine tissues. Laboratory Investigation, 1989 Apr, 60(4):548-56. 15. Hearn SA. Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique. Journal of Histochemistry and Cytochem, 1987, 35:795-801. 16. Wahl RL; Wilson BS; Liebert M; Beierwaltes WH. Highdose, unlabeled, nonspecific antibody pretreatment: influence on specific antibody localization to human melanoma xenografts. Cancer Immunology, Immunotherapy, 1987, 24(3):221-4. 17. Aguirre P; Scully RE; Wolfe HJ; DeLellis RA. Argyrophil cells in Brenner tumors: histochemical and immunohistochemical analysis. Int Journal of Gynecological Pathology, 1986, 5(3):223-34. 18. Wilson BS; Phan SH; Lloyd RV. Chromogranin from normal human adrenal glands: purification by monoclonal antibody affinity chromatography and partial N-terminal amino acid sequence. Regulatory Peptides, 1986 Feb, 13(3-4):207-23. 19. Bussolati G; Gugliotta P; Sapino A; Eusebi V; Lloyd RV. Chromogranin-reactive endocrine cells in argyrophilic carcinomas ("carcinoids") and normal tissue of the breast. Am J of Pathol, 1985, 120:186-92. 20. Varndell IM; Lloyd RV; Wilson BS; Polak JM. Ultrastructural localization of chromogranin: a potential marker for the electron microscopical recognition of endocrine cell secretory granules. Histochemical Journal, 1985 Sep, 17(9):981-92. 21. DeStephano DB; Lloyd RV; Pike AM; Wilson BS. Pituitary adenomas. An immunohistochemical study of hormone production and chromogranin localization. American Journal of Pathology, 1984 Sep, 116(3):464-72. 22. Wilson BS; Lloyd RV. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. American Journal of Pathology, 1984 Jun, 115(3):458-68. 23. Lloyd RV; Wilson BS. Specific endocrine tissue marker defined by a monoclonal antibody. Science, 1983 Nov 11, 222(4624):628-30. 24. Dottorini ME; Assi A; Sironi M; Sangalli G; Spreafico G; Colombo L. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables. Cancer, 1996 Apr 15, 77(8):1556-65. 25. Bjerkehagen B; Fossa SD; Raabe N; Holm R; Nesland JM. Transitional cell carcinoma of the renal pelvis and its expression of p53 protein, c-erbB-2 protein, neuron-specific enolase, Phe 5, chromo-granin, laminin and collagen type IV. European Urology, 1994, 26(4):334-9. 26. Haddad MG; Silverman JF. Fine-needle aspiration cytology of metastatic basal cell carcinoma of the skin to the lung. Diagnostic Cytopathology, 1994, 10(1):15-9. 27. Munoz DG. Chromogranin A-like immuno-reactive neurites are major constituents of senile plaques. Laboratory Investigation, 1991, 64:826-32.

Other Notes

Small volumes of anti-CHGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHGA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
chromogranin-A isoform 1 preproprotein
NCBI Official Synonym Full Names
chromogranin A (parathyroid secretory protein 1)
NCBI Official Symbol
CHGA
NCBI Official Synonym Symbols
CGA
Protein Family
NCBI Protein Information
chromogranin-A; SP-I; betagranin (N-terminal fragment of chromogranin A); catestatin; chromofungin; parathyroid secretory protein 1; pituitary secretory protein I

NCBI Summary for CHGA

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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