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DOCK2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626794

DOCK2 (Dedicator of cytokinesis protein 2) is a member of the DOCK-A family, DOCK180 superfamily of proteins. Its predicted molecular weight is 210kD, although it may run approximately at 190kD in SDS-PAGE. It is found in hematopoietic cell types, and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DOCK2, Polyclonal Antibody
Full Product Name
DOCK2 (Dedicator of Cytokinesis Protein 2, KIAA0209)
Product Gene Name
anti-DOCK2 antibody
Product Synonym Names
Anti -DOCK2 (Dedicator of Cytokinesis Protein 2, KIAA0209)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Goat, Human
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human DOCK2. Species sequence homology: mouse (96%).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
211,948 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (169064251..169510386). Location: 5q35.1
OMIM
603122
3D Structure
ModBase 3D Structure for Q92608
Immunogen
Purified, E. coli-derived recombinant human DOCK2 (aa420-642; Accession #Q92608).

Product Categories/Family for anti-DOCK2 antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-DOCK2 antibody
Western Blot (WB)
Application Notes for anti-DOCK2 antibody
Suitable for use in Western Blot.
Dilution: Western Blot:1g/ml

Other Notes

Small volumes of anti-DOCK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DOCK2 purchase

MBS626794 is an antibody targeting DOCK2. Also known as DOCK2 (Dedicator of Cytokinesis Protein 2, KIAA0209). Reactive in Goat, Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for DOCK2. It may not necessarily be applicable to this product.

NCBI GI #
31377468
NCBI GeneID
1794
NCBI Accession #
NP_004937.1
UniProt Primary Accession #
Q92608
UniProt Secondary Accession #
Q2M3I0; Q96AK7
UniProt Related Accession #
Q5XG91; Q6ZNS5; Q92608
GenBank Nucleotide #
NM_004946.2
NCBI Official Full Name
dedicator of cytokinesis protein 2
NCBI Official Synonym Full Names
dedicator of cytokinesis 2
NCBI Official Symbol
DOCK2
NCBI Official Synonym Symbols
FLJ46592; KIAA0209
UniProt Protein Name
Dedicator of cytokinesis protein 2
Protein Family
Dedicator of cytokinesis protein
UniProt Gene Name
DOCK2
UniProt Synonym Gene Names
KIAA0209
UniProt Entry Name
DOCK2_HUMAN
NCBI Protein Information
dedicator of cytokinesis protein 2; OTTHUMP00000160994; OTTHUMP00000223166; dedicator of cyto-kinesis 2

NCBI Summary for DOCK2

The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.[supplied by OMIM]

UniProt Comments for DOCK2

DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, Rac/Rho; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytoskeleton; membrane; endomembrane system; cytosol

Molecular Function: protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding

Biological Process: alpha-beta T cell proliferation; viral reproduction; formation of immunological synapse; myeloid dendritic cell activation during immune response; small GTPase mediated signal transduction; positive regulation of phagocytosis; establishment of T cell polarity; lipid raft polarization; chemotaxis; actin cytoskeleton organization and biogenesis; negative thymic T cell selection; regulation of defense response to virus by virus; positive thymic T cell selection

Disease: Immunodeficiency 40
Show more

Research Articles on DOCK2

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOCK2 antibody

 Reference Product  PubMed Publications
 RAC1 antibody  >16 publications with DOCK2 and RAC1
 RAC2 antibody  >6 publications with DOCK2 and RAC2
 ELMO1 antibody  >5 publications with DOCK2 and ELMO1
 VAV1 antibody  >4 publications with DOCK2 and VAV1
 CRKL antibody  >1 publications with DOCK2 and CRKL

Pathways associated with anti-DOCK2 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Nef And Signal Transduction Pathway antibodies  Nef And Signal Transduction Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram

Diseases associated with anti-DOCK2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with DOCK2 and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with DOCK2 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with DOCK2 and Prostatic Neoplasms

Organs/Tissues associated with anti-DOCK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with DOCK2 and Blood
 Spleen Antibodies  >5 publications with DOCK2 and Spleen
 Lymph Antibodies  >5 publications with DOCK2 and Lymph
 Lymph Node Antibodies  >5 publications with DOCK2 and Lymph Node
 Bone Antibodies  >3 publications with DOCK2 and Bone
 Thymus Antibodies  >3 publications with DOCK2 and Thymus
 Prostate Antibodies  >2 publications with DOCK2 and Prostate
 Liver Antibodies  >2 publications with DOCK2 and Liver
 Brain Antibodies  >2 publications with DOCK2 and Brain
 Eye Antibodies  >1 publications with DOCK2 and Eye
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