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CD3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6268441

MBS6268441 is an antibody targeting CD3. Also known as CD3 (APC). Reactive in Human. Host: Mouse. More details

$1170 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD3, Monoclonal Antibody
Full Product Name
CD3 (APC)
Product Gene Name
anti-CD3 antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
MEM-57
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CD3. Species Crossreactivity: Chimpanzee
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
171
OMIM
phenotype 615617
3D Structure
ModBase 3D Structure for P04234
Conjugate
APC

Product Categories/Family for anti-CD3 antibody

Antibodies; CD Markers

Testing Data of anti-CD3 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD3:FITC
Mouse Anti-CD3 Monoclonal Antibody – Cat# MBS6268441

Testing Data of anti-CD3 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD3:RPE
Mouse Anti-CD3 Monoclonal Antibody, Testing Data – Cat# MBS6268441

Product References and Citations for anti-CD3 antibody

1. Horejsi, V. et al. (1998) Monoclonal antibodies against human leucocyte antigens II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA) transferrin receptor (T9), a novel broadly expressed 18kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74). Folia. Biol. (Praha). 34: 23-34. 2. Dave, V.P. et al. (1998) Altered functional responsiveness of thymocyte subsets from CD3delta- deficient mice to TCR-CD3 engagement. Int Immunol. 10: 1481-90. 3. Transy, C. et al. (1989) Most anti-human CD3 monoclonal antibodies are directed to the CD3 epsilon subunit. Eur J Immunol. 19: 947-50. 4. Amlot, P.L. et al. (1996) Activation antigen expression on human T cells. I. Analysis by two-color flow cytometry of umbilical cord blood, adult blood and lymphoid tissue. Clin Exp Immunol. 105: 176-82. 5. Gunnlaugsdottir, B. et al. (2008) Naive human T-cells become non-responsive towards anti-TNFalpha (infliximab) treatment in vitro if co-stimulated through CD28. Scand J Immunol. 68: 624-34. 6. Morris, R.J. et al. (2005) A high-efficiency system of natural killer cell cloning. J Immunol Methods. 307: 24-33.

Other Notes

Small volumes of anti-CD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3. It may not necessarily be applicable to this product.

NCBI GI #
115985
NCBI GeneID
915
NCBI Accession #
P04234.1
UniProt Primary Accession #
P04234
UniProt Secondary Accession #
A8MVP6
UniProt Related Accession #
P04234
NCBI Official Full Name
T-cell surface glycoprotein CD3 delta chain
NCBI Official Synonym Full Names
CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol
CD3D
NCBI Official Synonym Symbols
T3D; IMD19; CD3-DELTA
UniProt Protein Name
T-cell surface glycoprotein CD3 delta chain
UniProt Synonym Protein Names
T-cell receptor T3 delta chain; CD_antigen: CD3d
Protein Family
CD302 antigen
UniProt Gene Name
CD3D
UniProt Synonym Gene Names
T3D
UniProt Entry Name
CD3D_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex)

NCBI Summary for CD3

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
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UniProt Comments for CD3

CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex

Molecular Function: transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection

Disease: Immunodeficiency 19
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Research Articles on CD3

1. Two cases of SCID with CD3delta gene mutation in Mexican Mennonite infants are described.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD3 antibody

 Reference Product  PubMed Publications
 CD3G antibody  >15 publications with CD3 and CD3G
 CD3E antibody  >13 publications with CD3 and CD3E
 LCK antibody  >5 publications with CD3 and LCK
 ZAP70 antibody  >4 publications with CD3 and ZAP70
 CD8A antibody  >4 publications with CD3 and CD8A
 CD247 antibody  >4 publications with CD3 and CD247
 ITK antibody  >3 publications with CD3 and ITK
 FYN antibody  >2 publications with CD3 and FYN
 CD8B antibody  >1 publications with CD3 and CD8B

Pathways associated with anti-CD3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD3 antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >7 publications with CD3 and Lymphoma
 Inflammation Antibodies  >5 publications with CD3 and Inflammation
 Severe Combined Immunodeficiency Antibodies  >4 publications with CD3 and Severe Combined Immunodeficiency
 Breast Neoplasms Antibodies  >3 publications with CD3 and Breast Neoplasms
 Necrosis Antibodies  >3 publications with CD3 and Necrosis
 Anemia Antibodies  >1 publications with CD3 and Anemia
 Uterine Neoplasms Antibodies  >1 publications with CD3 and Uterine Neoplasms
 Myocardial Infarction Antibodies  >1 publications with CD3 and Myocardial Infarction
 Lung Neoplasms Antibodies  >1 publications with CD3 and Lung Neoplasms

Organs/Tissues associated with anti-CD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with CD3 and Blood
 Thymus Antibodies  >4 publications with CD3 and Thymus
 Heart Antibodies  >3 publications with CD3 and Heart
 Intestine Antibodies  >2 publications with CD3 and Intestine
 Bone Marrow Antibodies  >2 publications with CD3 and Bone Marrow
 Spleen Antibodies  >1 publications with CD3 and Spleen
 Lymph Node Antibodies  >1 publications with CD3 and Lymph Node
 Lung Antibodies  >1 publications with CD3 and Lung
 Muscle Antibodies  >1 publications with CD3 and Muscle
 Eye Antibodies  >1 publications with CD3 and Eye
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