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CD68 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6268589

MBS6268589 is an antibody targeting CD68. Also known as CD68 (DKFZp686M18236, GP110, Macrophage Antigen CD68 (Microsialin), Macrosialin, Scavenger Receptor Class D Member 1, SCARD1) (APC). Reactive in Mouse. Host: Rat. More details

$1095 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD68, Monoclonal Antibody
Full Product Name
CD68 (DKFZp686M18236, GP110, Macrophage Antigen CD68 (Microsialin), Macrosialin, Scavenger Receptor Class D Member 1, SCARD1) (APC)
Product Gene Name
anti-CD68 antibody
Product Synonym Names
CD68 Antigen; CD68 Molecule; Monocytes/Macrophages
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
10B1906
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes mouse CD68. Detects surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
33,844 Da
3D Structure
ModBase 3D Structure for P31996
Immunogen
Purified Concanavalin A acceptor glycoprotein from P815 cell line
Conjugate
APC

Product Categories/Family for anti-CD68 antibody

Antibodies; Receptors; Scavenger
Applications Tested/Suitable for anti-CD68 antibody
Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Testing Data of anti-CD68 antibody

Staining of permeabilised mouse peritoneal macrophages with C2423-05P1.
Rat Anti-CD68 Monoclonal Antibody – Cat# MBS6268589

Testing Data of anti-CD68 antibody

Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68: RPE
Rat Anti-CD68 Monoclonal Antibody, Testing Data – Cat# MBS6268589

Testing Data of anti-CD68 antibody

Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68:Alexa Fluor® 647
Rat Anti-CD68 Monoclonal Antibody, Testing Data – Cat# MBS6268589

Product References and Citations for anti-CD68 antibody

1. Ramprasad, M.P. et al. (1996) Proc. Natl. Acad. Sci. 93: 14833-14838. 2. Rabinowitz, S.S. & Gordon, S. (1991) J. Exp. Med. 174: 827-836. 3. Da Silva, R.P & Gordon, S. (1999) Biochem. J. 338: 687-694. 4. Schleicher, U. et al. (2005). Blood 105: 1319-1328.5. von Lukowicz, T. et al. (2008) P PloS ONE 5: e13424.7. Rahaman, S.O. et al. (2011) J Biol Chem. Jan 5. 8. Frossard, J.L. et al. (2011) J Clin Pathol. Feb 23. 9. West, E.L. et al. (2010) Stem Cells. 28: 1997-2007. 10. Lopez, M.E. et al. (2011) J Neurosci. 31: 4367-78. 11. Jayagopal, A. et al. (2009) Nanotechnology. 20: 165102. 12. Leung, V.W. et al. (2009) Am J Pathol. 175: 1757-67. 13. Devey, L. et al. (2009) Mol Ther. 17: 65-72. 14. Lu, W. et al. (2010) Biomaterials. 31: 2617-26. 15. de Beer, M.C. et al. (2003) J Lipid Res. 44: 674- 85. 16. Song, L. et al. (2011) J Lipid Res. 52: 1542-50. 17. Daldrup-Link, H.E. et al. (2011)Clin Cancer Res. Jul 26. 18. Macauley, S.L. et al. (2011)J. Neurosci 31: 15575-85 19. Martin-Manso, G. et al. (2008) Cancer Res. 68: 7090-9. 20. Lazarini, F. et al. (2012) J Neurosci 32: 3652-64. 21. Hemmi, H. et al. (2009) J Immunol. 182: 1278-86. 22. Akbarshahi, H. et al. (2012) PLoS One. 7: e42654.

Other Notes

Small volumes of anti-CD68 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD68. It may not necessarily be applicable to this product.

NCBI GI #
399215
NCBI GeneID
12514
NCBI Accession #
P31996.1
UniProt Primary Accession #
P31996
UniProt Secondary Accession #
O54688; O70321; Q3S4A9; Q5F2A8; Q9DD15
UniProt Related Accession #
P31996
NCBI Official Full Name
Macrosialin
NCBI Official Synonym Full Names
CD68 antigen
NCBI Official Symbol
Cd68
NCBI Official Synonym Symbols
Lamp4; gp110; Scard1
UniProt Protein Name
Macrosialin
UniProt Synonym Protein Names
CD_antigen: CD68
Protein Family
Macrosialin
UniProt Gene Name
Cd68
UniProt Entry Name
CD68_MOUSE
NCBI Protein Information
macrosialin

UniProt Comments for CD68

CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: membrane; lysosome; integral to membrane; plasma membrane; endosome
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Research Articles on CD68

1. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD68 antibody

 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Macrophage Markers Pathway antibodies  Macrophage Markers Pathway Diagram

Diseases associated with anti-CD68 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1617 publications with CD68 and Inflammation
 Nervous System Diseases Antibodies  >995 publications with CD68 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >909 publications with CD68 and Cardiovascular Diseases
 Necrosis Antibodies  >881 publications with CD68 and Necrosis
 Fibrosis Antibodies  >475 publications with CD68 and Fibrosis
 Lung Diseases Antibodies  >444 publications with CD68 and Lung Diseases
 Disease Models, Animal Antibodies  >442 publications with CD68 and Disease Models, Animal
 Kidney Diseases Antibodies  >369 publications with CD68 and Kidney Diseases
 Atherosclerosis Antibodies  >345 publications with CD68 and Atherosclerosis
 Adenocarcinoma Antibodies  >301 publications with CD68 and Adenocarcinoma

Organs/Tissues associated with anti-CD68 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1049 publications with CD68 and Muscle
 Skin Antibodies  >891 publications with CD68 and Skin
 Bone Antibodies  >840 publications with CD68 and Bone
 Lymph Node Antibodies  >534 publications with CD68 and Lymph Node
 Liver Antibodies  >523 publications with CD68 and Liver
 Lung Antibodies  >497 publications with CD68 and Lung
 Kidney Antibodies  >478 publications with CD68 and Kidney
 Connective Tissue Antibodies  >424 publications with CD68 and Connective Tissue
 Joint Antibodies  >382 publications with CD68 and Joint
 Heart Antibodies  >363 publications with CD68 and Heart
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