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PIK4CB (PI4KB) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626890

PIK4CB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. More details

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Product Overview

Online Datasheet in PDF
Product Name
PIK4CB (PI4KB), Polyclonal Antibody
Full Product Name
PIK4CB (Phosphatidylinositol 4-kinase Catalytic beta, Phosphatidylinositol 4-kinase beta, PI4Kbeta, PI4K-beta, PI4KB, PI4KIIIbeta, PtdIns 4-kinase beta, PI4K92, NPIK)
Product Gene Name
anti-PI4KB antibody
Product Synonym Names
Anti -PIK4CB (Phosphatidylinositol 4-kinase Catalytic beta, Phosphatidylinositol 4-kinase beta, PI4Kbeta, PI4K-beta, PI4KB, PI4KIIIbeta, PtdIns 4-kinase beta, PI4K92, NPIK)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PIK4CB.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
91,379 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (151264273..151300191, complement). Location: 1q21
OMIM
602758
3D Structure
ModBase 3D Structure for Q9UBF8
Immunogen
Synthetic peptide selected from the Center region of human PIK4CB (KLH).

Product Categories/Family for anti-PI4KB antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PI4KB antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PI4KB antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PI4KB antibody

Western blot analysis of PIK4CB Antibody (Center) in Hela cell line lysates (35ug/lane). PIK4CB (arrow) was detected using the purified Pab.
Rabbit Anti-PI4KB Polyclonal Antibody – Cat# MBS626890

Immunohistochemistry (IHC) of anti-PI4KB antibody

Formalin-fixed and paraffin-embedded human skeletal muscle reacted with PIK4CB Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PI4KB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS626890

Flow Cytometry (FC/FACS) of anti-PI4KB antibody

PIK4CB Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PI4KB Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS626890

Other Notes

Small volumes of anti-PI4KB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PI4KB purchase

MBS626890 is an antibody targeting PI4KB. Also known as PIK4CB (Phosphatidylinositol 4-kinase Catalytic beta, Phosphatidylinositol 4-kinase beta, PI4Kbeta, PI4K-beta, PI4KB, PI4KIIIbeta, PtdIns 4-kinase beta, PI4K92, NPIK). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PI4KB. It may not necessarily be applicable to this product.

NCBI GI #
311771625
NCBI GeneID
5298
NCBI Accession #
NP_001185704.1
UniProt Primary Accession #
Q9UBF8
UniProt Secondary Accession #
O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; B4DGI2
UniProt Related Accession #
Q9UBF8
GenBank Nucleotide #
NM_001198775.1
NCBI Official Full Name
phosphatidylinositol 4-kinase beta isoform 3
NCBI Official Synonym Full Names
phosphatidylinositol 4-kinase, catalytic, beta
NCBI Official Symbol
PI4KB
NCBI Official Synonym Symbols
NPIK; PI4K92; PIK4CB; PI4KBETA; PI4K-BETA; PI4KIIIBETA
UniProt Protein Name
Phosphatidylinositol 4-kinase beta
UniProt Synonym Protein Names
NPIK; PI4K92
Protein Family
Phosphatidylinositol 4-kinase
UniProt Gene Name
PI4KB
UniProt Synonym Gene Names
PIK4CB; PI4K-beta; PI4Kbeta
UniProt Entry Name
PI4KB_HUMAN
NCBI Protein Information
phosphatidylinositol 4-kinase beta; PtdIns 4-kinase beta; type III phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, wortmannin-sensitive

UniProt Comments for PI4KB

PIK4CB: a member of the PI3/PI4 kinase family. Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Three splice-variant isoforms have been described.

Protein type: Kinase, lipid; EC 2.7.1.67; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: Golgi membrane; mitochondrial outer membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; rough endoplasmic reticulum membrane; cytosol; endosome

Molecular Function: 1-phosphatidylinositol 4-kinase activity; protein binding; ATP binding

Biological Process: receptor-mediated endocytosis; phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction
Show more

Research Articles on PI4KB

1. The lipid kinase PI4KIIIbeta preserves lysosomal identity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PI4KB antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-PI4KB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with PI4KB and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with PI4KB and Liver Diseases

Organs/Tissues associated with anti-PI4KB antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with PI4KB and Bone
 Liver Antibodies  >1 publications with PI4KB and Liver
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