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Lysosome Associated Membrane Protein 2 (LAMP2) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6268957

MBS6268957 is an antibody targeting LAMP2. Also known as Lysosome Associated Membrane Protein 2 (LAMP2, Igp2, Igp110, CD107b, LAMP2C, LAMPB, Lysosome Associated Membrane Glycoprotein 2 Precursor, MAC3) (APC). Reactive in Mouse. Host: Rat. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Lysosome Associated Membrane Protein 2 (LAMP2), Monoclonal Antibody
Full Product Name
Lysosome Associated Membrane Protein 2 (LAMP2, Igp2, Igp110, CD107b, LAMP2C, LAMPB, Lysosome Associated Membrane Glycoprotein 2 Precursor, MAC3) (APC)
Product Gene Name
anti-LAMP2 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
M3/84
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes murine CD107b.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
45,655 Da
3D Structure
ModBase 3D Structure for P17047
Immunogen
Glycoproteins purified from mouse peritoneal macrophage membranes.
Conjugate
APC

Product Categories/Family for anti-LAMP2 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-LAMP2 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Testing Data of anti-LAMP2 antibody

Staining of mouse peritoneal macrophages with L9190-13A following permeabilsation with Leucoperm
Rat Anti-LAMP2 Monoclonal Antibody – Cat# MBS6268957

Testing Data of anti-LAMP2 antibody

Staining of mouse peritoneal macrophages with L9190-13A. Permeabilised with Leucoperm
Rat Anti-LAMP2 Monoclonal Antibody, Testing Data – Cat# MBS6268957

Testing Data of anti-LAMP2 antibody

Rat Anti-LAMP2 Monoclonal Antibody, Testing Data – Cat# MBS6268957

Testing Data of anti-LAMP2 antibody

Rat Anti-LAMP2 Monoclonal Antibody, Testing Data – Cat# MBS6268957

Product References and Citations for anti-LAMP2 antibody

1. Springer, T.A. (1981) Monoclonal antibody analysis of complex biological systems. Combination of cell hybridization and immunoadsorbents in a novel cascade procedure and its application to the macrophage cell surface J. Biol. Chem. 256:3833-3839. 2. Flotte, T.J. et al. (1983) Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. Am. J. Pathol. 111:112-124. 3. Ho, M.K. and Springer, T.A. (1983) Tissue distribution, structural characterization and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity. J. Biol. Chem. 258:636-642.

Other Notes

Small volumes of anti-LAMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LAMP2. It may not necessarily be applicable to this product.

NCBI GI #
63054837
NCBI GeneID
16784
NCBI Accession #
NP_001017959.1
UniProt Primary Accession #
P17047
UniProt Secondary Accession #
Q3TXG5; Q8BSG8; A2A430
UniProt Related Accession #
P17047
GenBank Nucleotide #
NM_001017959.2
NCBI Official Full Name
lysosome-associated membrane glycoprotein 2 isoform 1
NCBI Official Synonym Full Names
lysosomal-associated membrane protein 2
NCBI Official Symbol
Lamp2
NCBI Official Synonym Symbols
Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
UniProt Protein Name
Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names
CD107 antigen-like family member B; Lysosomal membrane glycoprotein type B; LGP-B; CD_antigen: CD107b
Protein Family
Lysosome-associated membrane glycoprotein
UniProt Gene Name
Lamp2
UniProt Synonym Gene Names
Lamp-2; LAMP-2; Lysosome-associated membrane protein 2; LGP-B
NCBI Protein Information
lysosome-associated membrane glycoprotein 2

UniProt Comments for LAMP2

LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: X A3.3|X 22.67 cM

Cellular Component: endosome; extracellular space; late endosome; late endosome membrane; lipid raft; lysosomal membrane; lysosome; membrane; phagocytic vesicle membrane; platelet dense granule membrane

Molecular Function: enzyme binding; protein domain specific binding

Biological Process: muscle maintenance; protein stabilization; regulation of protein stability
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Research Articles on LAMP2

1. LAMP-2 in the central nervous system has a possible role in the degradation of the various macromolecules in lysosomes and an additional function concerning protection from oxidative stress, especially in the substantia nigra.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LAMP2 antibody

 Reference Product  PubMed Publications
 Rab7 antibody  >17 publications with LAMP2 and Rab7
 Cd63 antibody  >11 publications with LAMP2 and Cd63
 Hspa8 antibody  >9 publications with LAMP2 and Hspa8
 Uchl1 antibody  >1 publications with LAMP2 and Uchl1
 Gba antibody  >1 publications with LAMP2 and Gba
 Anxa4 antibody  >1 publications with LAMP2 and Anxa4

Pathways associated with anti-LAMP2 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-LAMP2 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >81 publications with LAMP2 and Heart Diseases
 Cardiomyopathies Antibodies  >73 publications with LAMP2 and Cardiomyopathies
 Neurobehavioral Manifestations Antibodies  >54 publications with LAMP2 and Neurobehavioral Manifestations
 Glycogen Storage Disease Type IIb Antibodies  >53 publications with LAMP2 and Glycogen Storage Disease Type IIb
 Disease Models, Animal Antibodies  >23 publications with LAMP2 and Disease Models, Animal
 Immune System Diseases Antibodies  >18 publications with LAMP2 and Immune System Diseases
 Cardiomegaly Antibodies  >17 publications with LAMP2 and Cardiomegaly
 Inflammation Antibodies  >17 publications with LAMP2 and Inflammation
 Kidney Diseases Antibodies  >14 publications with LAMP2 and Kidney Diseases
 Movement Disorders Antibodies  >14 publications with LAMP2 and Movement Disorders

Organs/Tissues associated with anti-LAMP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >51 publications with LAMP2 and Brain
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