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Macrophage Scavenger Receptor Type I (MSR1) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6268961

MBS6268961 is an antibody targeting MSR1. Also known as Macrophage Scavenger Receptor Type I (MSR1, CD204, Macrophage Acetylated LDL Receptor I and II, Macrophage Scavenger Receptor Types I and II, phSR1, Scavenger Receptor Class A Member 1, SCARA1, Scavenger… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Macrophage Scavenger Receptor Type I (MSR1), Monoclonal Antibody
Full Product Name
Macrophage Scavenger Receptor Type I (MSR1, CD204, Macrophage Acetylated LDL Receptor I and II, Macrophage Scavenger Receptor Types I and II, phSR1, Scavenger Receptor Class A Member 1, SCARA1, Scavenger Receptor Type A, SRA, Scvr) (APC)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
10B1015
Host
Rat
Species Reactivity
Porcine
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes mouse Macrophage Scavenger Receptor Type I and II. Reacts with an epitope within Macrophage Scavenger Receptor Type I that is polymorphic in the Macrophage Scavenger Receptor Type I from C57BL/6 mice and is therefore unsuitable for use with the C57BL/6 mouse strain. Species Crossreactivity: channel catfish, porcine
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
38,773 Da
3D Structure
ModBase 3D Structure for P30204
Immunogen
Raw 264 cell line.
Conjugate
APC

Product Categories/Family for anti-MSR1 antibody

Applications Tested/Suitable for anti-MSR1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Testing Data of anti-MSR1 antibody

Staining of J774 cell line with M1210-04C.
Rat Anti-MSR1 Monoclonal Antibody – Cat# MBS6268961

Product References and Citations for anti-MSR1 antibody

1. Fraser, I.P. et al. (1993) Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature 364: 343-346. 2. de Villiers, W.J.S. et al. (1994) Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function J. Exp. Med. 180: 705-709. 3. Hughes, D.A.et al. (1995) Murine Macrophage Scavenger Receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs. Eur. J. Immunol. 25: 466-473. 4. Bell, M.D.et al. (1994) Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS. J. Neurocytol. 23: 605-613. 5. Hughes, D.A. et al. (1994) Murine Macrophage Scavenger Receptor: Adhesion function and Expression. Imm. Letts. 43: 7-14. 6. Rosen, H. and Hughes, D.A. (1995) Assays of Myeloid Cell Function: Migration and adhesion in vivo. Weir Handbook of Experimental Immunology. London, Blackwell Scientific Publications. 5th, ed. In Press. 7. Daugherty, A. et al. (2000) Polymorphism of class A scavenger receptors in C57BL/6 mice. J. Lipid Res 41: 1568 - 1577. 8. Moldenhauer, L.M. et al. (2010) GM-CSF Is an Essential Regulator of T Cell Activation Competence in Uterine Dendritic Cells during Early Pregnancy in Mice. J Immunol. 185: 7085-7096. 9. Luechtenborg, B. et al. (2008) Function of scavenger receptor class A type I/II is not important for smooth muscle foam cell formation. Eur J Cell Biol. 87: 91-9. 10. Sever-Chroneos, Z. et al. (2011) Surfactant Protein A (SP-A)-mediated Clearance of Staphylococcus aureus Involves Binding of SP-A to the Staphylococcal Adhesin Eap and the Macrophage Receptors SP-A Receptor 210 and Scavenger Receptor Class A. J Biol Chem. 286: 4854-70. 11. Yang, C.N. et al. (2011) Mechanism mediating oligomeric Aß clearance by naïve primary microglia. Neurobiol Dis. Jan 8. 12. Hald, A. et al. (2011) MMP9 is protective against lethal inflammatory mass lesions in the mouse colon. Dis Model Mech. 4: 212-27. 13. Swain, S.D. et al. (2011) Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens. Infect Immun. Feb 22. 14. Nikolic, D. et al. (2011) SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation.BMC Immunol. 12: 37. 15. Zaynagetdinov, R. et al. (2011) A Critical Role for Macrophages in Promotion of Urethane-Induced Lung Carcinogenesis. J Immunol. Nov 2. 16. Kaur, H. et al. (2003) Identification of a scavenger receptor homologue on nonspecific cytotoxic cells and evidence for binding to oligodeoxyguanosine. Fish Shellfish Immunol. 15: 169-81. 17. Kaur, H. et al. (2004) Single-base oligodeoxyguanosine-binding proteins on nonspecific cytotoxic cells: identification of a new class of pattern-recognition receptors. Scand J Immunol. 60: 238-48.

Other Notes

Small volumes of anti-MSR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MSR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
macrophage scavenger receptor types I and II isoform a
NCBI Official Synonym Full Names
macrophage scavenger receptor 1
NCBI Official Symbol
Msr1
NCBI Official Synonym Symbols
MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
UniProt Protein Name
Macrophage scavenger receptor types I and II
UniProt Synonym Protein Names
Macrophage acetylated LDL receptor I and II; Scavenger receptor type A; SR-A; CD_antigen: CD204
UniProt Gene Name
Msr1
UniProt Synonym Gene Names
Scvr; SR-A
UniProt Entry Name
MSRE_MOUSE
NCBI Protein Information
macrophage scavenger receptor types I and II

UniProt Comments for MSR1

MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: collagen; membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; cytosol

Molecular Function: low-density lipoprotein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol transport; lipoprotein transport; endocytosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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