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TIM-1 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6269207

MBS6269207 is an antibody targeting TIM-1. Also known as TIM-1 (T-Cell Immunoglobin Mucin-1, KIM1, TIM1, TIMD1, HAVCR1) (APC). Reactive in Mouse. Host: Rat. More details

$1040 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TIM-1, Monoclonal Antibody
Full Product Name
TIM-1 (T-Cell Immunoglobin Mucin-1, KIM1, TIM1, TIMD1, HAVCR1) (APC)
Product Gene Name
anti-TIM-1 antibody
Product Synonym Gene Name
Havcr1
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
RMT1-10
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes mouse TIM-1.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
30,925 Da
3D Structure
ModBase 3D Structure for Q5QNS5
Immunogen
Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
Conjugate
APC

Product Categories/Family for anti-TIM-1 antibody

Antibodies; T Cells; Lymphocytes

Product References and Citations for anti-TIM-1 antibody

1. Xiao, S. et al. (2007) Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.J. Exp. Med. 204:1691-1702. 2. Yuan, X. et al. (2009) Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. P.N.A.S. 106: 10734-10739. 3. Ueno, T. et al. (2008) The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.J Clin Invest. 118: 742-51. 4. Fukushima, A. et al. (2007) Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis.Biochem Biophys Res Commun. 353: 211-6. 5. Rong, S. et al. (2011) The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury.J Am Soc Nephrol. 22: 484-95. 6. Freeman, G.J. et al. (2010) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 235: 172-189.

Other Notes

Small volumes of anti-TIM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TIM-1. It may not necessarily be applicable to this product.

NCBI GI #
262231823
NCBI GeneID
171283
NCBI Accession #
NP_001160103.1
UniProt Primary Accession #
Q5QNS5
UniProt Secondary Accession #
Q7TPU2; Q8VIM1; Q8VIM2
UniProt Related Accession #
Q5QNS5
GenBank Nucleotide #
NM_001166631.1
NCBI Official Full Name
hepatitis A virus cellular receptor 1 homolog isoform b
NCBI Official Synonym Full Names
hepatitis A virus cellular receptor 1
NCBI Official Symbol
Havcr1
NCBI Official Synonym Symbols
Tim1; KIM-1; TIM-1; Timd1; AI503787
UniProt Protein Name
Hepatitis A virus cellular receptor 1 homolog
UniProt Synonym Protein Names
Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T cell membrane protein 1; T-cell immunoglobulin mucin receptor 1; TIM-1
Protein Family
Protein timeless
UniProt Gene Name
Havcr1
UniProt Synonym Gene Names
Kim1; Tim1; Timd1; HAVcr-1; KIM-1; TIMD-1; TIM-1
UniProt Entry Name
HAVR1_MOUSE
NCBI Protein Information
hepatitis A virus cellular receptor 1 homolog

UniProt Comments for TIM-1

TIM-1: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Belongs to the immunoglobulin superfamily. TIM family.

Protein type: Membrane protein, integral

Cellular Component: cell surface

Molecular Function: phosphatidylserine binding; protein binding

Biological Process: positive regulation of mast cell activation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TIM-1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >278 publications with TIM-1 and Kidney Diseases
 Acute Kidney Injury Antibodies  >224 publications with TIM-1 and Acute Kidney Injury
 Renal Insufficiency Antibodies  >168 publications with TIM-1 and Renal Insufficiency
 Proteinuria Antibodies  >66 publications with TIM-1 and Proteinuria
 Inflammation Antibodies  >55 publications with TIM-1 and Inflammation
 Cardiovascular Diseases Antibodies  >49 publications with TIM-1 and Cardiovascular Diseases
 Necrosis Antibodies  >38 publications with TIM-1 and Necrosis
 Lung Diseases Antibodies  >37 publications with TIM-1 and Lung Diseases
 Disease Models, Animal Antibodies  >35 publications with TIM-1 and Disease Models, Animal
 Liver Diseases Antibodies  >29 publications with TIM-1 and Liver Diseases

Organs/Tissues associated with anti-TIM-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >79 publications with TIM-1 and Other
 Lymph Node Antibodies  >3 publications with TIM-1 and Lymph Node
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