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CLK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626978

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The… More details

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Product Overview

Online Datasheet in PDF
Product Name
CLK1, Polyclonal Antibody
Full Product Name
CLK1, NT (Dual Specificity Protein Kinase CLK1, CDC-like Kinase 1, CLK)
Product Gene Name
Product Synonym Names
Anti -CLK1, NT (Dual Specificity Protein Kinase CLK1, CDC-like Kinase 1, CLK)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CLK1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
57,291 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (201717732..201729467, complement). Location: 2q33
OMIM
601951
3D Structure
ModBase 3D Structure for P49759
Immunogen
Synthetic peptide selected from the N-terminal region of human CLK1 (KLH).
Applications Tested/Suitable for anti-CLK1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CLK1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-CLK1 antibody

Western blot analysis of anti-hCLK1-C84 Pab in Y79 cell line lysate. hCLK1-C84(arrow) was detected using the purified Pab.
Rabbit Anti-CLK1 Polyclonal Antibody – Cat# MBS626978

Other Notes

Small volumes of anti-CLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLK1 purchase

MBS626978 is an antibody targeting CLK1. Also known as CLK1, NT (Dual Specificity Protein Kinase CLK1, CDC-like Kinase 1, CLK). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLK1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
clk1; putative
NCBI Official Synonym Full Names
CDC-like kinase 1
NCBI Official Symbol
CLK1
NCBI Official Synonym Symbols
CLK; STY; CLK/STY
UniProt Protein Name
Dual specificity protein kinase CLK1
UniProt Synonym Protein Names
CDC-like kinase 1
UniProt Gene Name
CLK1
UniProt Synonym Gene Names
CLK
UniProt Entry Name
CLK1_HUMAN
NCBI Protein Information
dual specificity protein kinase CLK1; OTTHUMP00000163673; OTTHUMP00000206165; OTTHUMP00000206166; CDC28/CDC2-like kinase; protein tyrosine kinase STY

NCBI Summary for CLK1

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for CLK1

CLK1: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing.

Protein type: Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; Kinase, protein; CMGC group; CLK family

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: cell proliferation; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLK1 antibody

Pathways associated with anti-CLK1 antibody

 Products by Pathway  Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
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