Rabbit Anti-TAOK1 Polyclonal Antibody – Cat# MBS626998

Western blot analysis of anti-TAOK1 Pab (AP7085c) in mouse brain tissue lysate (35ug/lane). TAOK1(arrow) was detected using the purified Pab.

TAO Kinase 1 (TAOK1) Antibody – Rabbit Polyclonal

Name: TAOK1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS626998
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626998

TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TAO Kinase 1 (TAOK1), Polyclonal Antibody

Full Product Name

TAO Kinase 1 (Thousand and One Amino Acid Protein Kinase 1, TAOK1, hTAOK1, TAO1, Kinase from Chicken Homolog B, KFC-B, hKFC-B, KIAA1361, MAP3K16, MARK Kinase, MARKK, Prostate-derived Sterile 20-like Kinase 2, Prostate-derived STE20-like Kinase 2, PSK2, PS

Product Gene Name

anti-TAOK1 antibody

Product Synonym Names

Anti -TAO Kinase 1 (Thousand and One Amino Acid Protein Kinase 1, TAOK1, hTAOK1, TAO1, Kinase from Chicken Homolog B, KFC-B, hKFC-B, KIAA1361, MAP3K16, MARK Kinase, MARKK, Prostate-derived Sterile 20-like Kinase 2, Prostate-derived STE20-like Kinase 2, PSK2, PS

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human TAOK1.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

116,070 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (27717943..27871502). Location: 17q11.2

OMIM

610266

3D Structure

ModBase 3D Structure for Q7L7X3

Immunogen

Synthetic peptide selected from the center region of human TAOK1 (KLH).

Product Categories/Family for anti-TAOK1 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-TAOK1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TAOK1 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Other Notes

Small volumes of anti-TAOK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAOK1 purchase

MBS626998 is an antibody targeting TAOK1. Also known as TAO Kinase 1 (Thousand and One Amino Acid Protein Kinase 1, TAOK1, hTAOK1, TAO1, Kinase from Chicken Homolog B, KFC-B, hKFC-B, KIAA1361, MAP3K16, MARK Kinase, MARKK, Prostate-derived Sterile 20-like Kinase 2, Prostate-derived STE20-like Kinase 2, PSK2, PS. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TAOK1. It may not necessarily be applicable to this product.

NCBI GI #

219519599

NCBI GeneID

57551

UniProt Primary Accession #

Q7L7X3

UniProt Secondary Accession #

Q96L75; Q9H2K7; Q9H7S5; Q9P2I6; A2RUT8

UniProt Related Accession #

Q7L7X3

NCBI Official Full Name

TAOK1 protein

NCBI Official Synonym Full Names

TAO kinase 1

NCBI Official Symbol

TAOK1

NCBI Official Synonym Symbols

PSK2; TAO1; KFC-B; MARKK; hKFC-B; MAP3K16; FLJ14314; KIAA1361

UniProt Protein Name

Serine/threonine-protein kinase TAO1

UniProt Synonym Protein Names

Kinase from chicken homolog B; hKFC-B; STE20-like kinase PSK2; Thousand and one amino acid protein 1

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

TAOK1

UniProt Synonym Gene Names

KIAA1361; MAP3K16

UniProt Entry Name

TAOK1_HUMAN

NCBI Protein Information

serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; kinase from chicken homolog B; thousand and one amino acid protein 1; serine/threonine protein kinase TAO1 homolog; microtubule affinity regulating kinase kinase

UniProt Comments for TAOK1

TAO1: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; TAO subfamily

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytosol

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: activation of MAPKK activity; spindle checkpoint; MAPKKK cascade; positive regulation of JNK cascade; mitotic cell cycle; DNA repair; G2/M transition DNA damage checkpoint; response to DNA damage stimulus; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; regulation of cytoskeleton organization and biogenesis

Research Articles on TAOK1

1. Data do not support the notion that Tao1 is a component of the spindle checkpoint.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TAOK1 antibody

Products by Pathway	Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Mitotic M-M/G1 Phases Pathway antibodies	Mitotic M-M/G1 Phases Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
P38 MAPK Signaling Pathway antibodies	P38 MAPK Signaling Pathway Diagram

Diseases associated with anti-TAOK1 antibody

Disease Name	Pubmed Publications
Female Urogenital Diseases Antibodies	>1 publications with TAOK1 and Female Urogenital Diseases
Hypospadias Antibodies	>1 publications with TAOK1 and Hypospadias
Genital Diseases, Male Antibodies	>1 publications with TAOK1 and Genital Diseases, Male

Organs/Tissues associated with anti-TAOK1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with TAOK1 and Blood
Vascular Antibodies	>1 publications with TAOK1 and Vascular
Heart Antibodies	>1 publications with TAOK1 and Heart
Kidney Antibodies	>1 publications with TAOK1 and Kidney
Muscle Antibodies	>1 publications with TAOK1 and Muscle
Intestine Antibodies	>1 publications with TAOK1 and Intestine