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5HT3E Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6270240

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. HTR3E encodes a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
5HT3E, Polyclonal Antibody
Full Product Name
5HT3E, ID (HTR3E, 5-hydroxytryptamine receptor 3E, Serotonin receptor 3E) (MaxLight 650)
Product Gene Name
anti-5HT3E antibody
Product Synonym Gene Name
HTR3E
Product Synonym Names
HTR3E; 5-hydroxytryptamine receptor 3E; Serotonin receptor 3E
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
53,700 Da
OMIM
610123
3D Structure
ModBase 3D Structure for A5X5Y0
Immunogen
5HT3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-162 amino acids from the Central region of human 5HT3E.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-5HT3E antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-5HT3E antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-5HT3E antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-5HT3E antibody

Walstab, J., et al. J. Biol. Chem. 285(35):26956-26965(2010). Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010). Lennertz, L., et al. Eur Neuropsychopharmacol 20(6):414-420(2010). Goecke, T.W., et al. Acta Obstet Gynecol Scand 89(1):7-14(2010). Schuhmacher, A., et al. Pharmacogenet. Genomics 19(11):843-851(2009).

Other Notes

Small volumes of anti-5HT3E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 5HT3E purchase

MBS6270240 is an antibody targeting 5HT3E. Also known as 5HT3E, ID (HTR3E, 5-hydroxytryptamine receptor 3E, Serotonin receptor 3E) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for 5HT3E. It may not necessarily be applicable to this product.

NCBI GI #
47519913
NCBI GeneID
285242
NCBI Accession #
NP_872395.2
UniProt Primary Accession #
A5X5Y0
UniProt Secondary Accession #
Q495G1; Q495G3; Q6V706; Q6V707; Q7Z6B2; A8IKD7; E9PGF1
UniProt Related Accession #
A5X5Y0
GenBank Nucleotide #
NM_182589.2
NCBI Official Full Name
5-hydroxytryptamine receptor 3E isoform a
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 3E
NCBI Official Symbol
HTR3E
NCBI Official Synonym Symbols
5-HT3E; 5-HT3-E; 5-HT3c1
UniProt Protein Name
5-hydroxytryptamine receptor 3E
UniProt Synonym Protein Names
Serotonin receptor 3E
UniProt Gene Name
HTR3E
UniProt Synonym Gene Names
5-HT3-E; 5-HT3E
UniProt Entry Name
5HT3E_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 3E

NCBI Summary for 5HT3E

This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
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UniProt Comments for 5HT3E

5-HT(3E): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: extracellular ligand-gated ion channel activity

Biological Process: transmembrane transport
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Research Articles on 5HT3E

1. the HTR3E remained significant after correction for the number of variants investigated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-5HT3E antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-5HT3E antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with 5HT3E and Breast Neoplasms
 Memory Disorders Antibodies  >1 publications with 5HT3E and Memory Disorders
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