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LTBP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627057

LTBP1 may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. This protein may play critical roles in controlling and directing the activity of TGFB1, and it may have a structural role in the extra… More details

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Product Overview

Online Datasheet in PDF
Product Name
LTBP1, Polyclonal Antibody
Full Product Name
LTBP1, CT (Latent-transforming Growth Factor beta Binding Protein 1, LTBP-1, MGC163161, Transforming Growth Factor beta-1 Binding Protein 1, TGF-beta1-BP-1)
Product Gene Name
anti-LTBP1 antibody
Product Synonym Names
Anti -LTBP1, CT (Latent-transforming Growth Factor beta Binding Protein 1, LTBP-1, MGC163161, Transforming Growth Factor beta-1 Binding Protein 1, TGF-beta1-BP-1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified by ammonium sulfate precipitation
Concentration
1.89 mg/mL (lot specific)
Specificity
Recognizes human LTBP1.
Preparation and Storage
May be stored at 4°C for short term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 2; NC_000002.11 (33172369..33624576). Location: 2p22-p21
OMIM
150390
3D Structure
ModBase 3D Structure for Q14766
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1493-1525 in the C-terminal region of human LTBP1.

Product Categories/Family for anti-LTBP1 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-LTBP1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry . Other applications have not been tested.
Application Notes for anti-LTBP1 antibody
Western Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50

Optimal dilutions to be determined by the researcher.

Western Blot (WB) of anti-LTBP1 antibody

Western Blot analysis in mouse bladder tissue lysates (35ug/lane) using MBS627057. This demonstrates that MBS627057 detected the LTBP1 protein (arrow).
Rabbit Anti-LTBP1 Polyclonal Antibody – Cat# MBS627057

Immunohistochemistry (IHC) of anti-LTBP1 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MBS627057, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS627057 for immunohistochemistry.
Rabbit Anti-LTBP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627057

Product References and Citations for anti-LTBP1 antibody

1.Olofsson A., J. Biol. Chem. 270:31294-31297(1995). 2.Kanzaki T., Cell 61:1051-1061(1990). 3.Isogai Z., J. Biol. Chem. 278:2750-2757(2003). 4.Oklu R., Biochem. J. 352:601-610(2000).

Other Notes

Small volumes of anti-LTBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LTBP1 purchase

MBS627057 is an antibody targeting LTBP1. Also known as LTBP1, CT (Latent-transforming Growth Factor beta Binding Protein 1, LTBP-1, MGC163161, Transforming Growth Factor beta-1 Binding Protein 1, TGF-beta1-BP-1). Reactive in Mouse.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LTBP1. It may not necessarily be applicable to this product.

NCBI GI #
261337173
NCBI GeneID
4052
NCBI Accession #
NP_001159738.1
UniProt Primary Accession #
Q14766
UniProt Secondary Accession #
P22064; Q53SD8; Q53SF3; Q53SG1; Q59HF7; Q8TD95; A1L3V1
UniProt Related Accession #
Q14766
GenBank Nucleotide #
NM_001166266.1
NCBI Official Full Name
latent-transforming growth factor beta-binding protein 1 isoform 5
NCBI Official Synonym Full Names
latent transforming growth factor beta binding protein 1
NCBI Official Symbol
LTBP1
NCBI Official Synonym Symbols
MGC163161
UniProt Protein Name
Latent-transforming growth factor beta-binding protein 1
UniProt Synonym Protein Names
Transforming growth factor beta-1-binding protein 1
Protein Family
Latent-transforming growth factor beta-binding protein
UniProt Gene Name
LTBP1
UniProt Entry Name
LTBP1_HUMAN
NCBI Protein Information
latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta1-BP-1; OTTHUMP00000201218; OTTHUMP00000201281; OTTHUMP00000201282; OTTHUMP00000201676; transforming growth factor beta-1-binding protein 1

NCBI Summary for LTBP1

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
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UniProt Comments for LTBP1

LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Chaperone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p22-p21

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; microfibril; extracellular region

Molecular Function: transforming growth factor beta receptor activity; protein binding; transforming growth factor beta binding; microfibril binding; calcium ion binding

Biological Process: extracellular matrix organization and biogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway
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Research Articles on LTBP1

1. a spliced variant form of latent transforming growth factor beta binding protein 1, LTBPD41 is highly expressed in advanced atherosclerotic lesions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LTBP1 antibody

 Reference Product  PubMed Publications
 FBN1 antibody  >2 publications with LTBP1 and FBN1
 IGFBP3 antibody  >1 publications with LTBP1 and IGFBP3

Pathways associated with anti-LTBP1 antibody

 Products by Pathway  Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-LTBP1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with LTBP1 and Cardiovascular Diseases
 Neoplasms Antibodies  >13 publications with LTBP1 and Neoplasms
 Heart Diseases Antibodies  >8 publications with LTBP1 and Heart Diseases
 Fibrosis Antibodies  >7 publications with LTBP1 and Fibrosis
 Congenital Abnormalities Antibodies  >7 publications with LTBP1 and Congenital Abnormalities
 Female Urogenital Diseases Antibodies  >7 publications with LTBP1 and Female Urogenital Diseases
 Arteriosclerosis Antibodies  >6 publications with LTBP1 and Arteriosclerosis
 Liver Diseases Antibodies  >5 publications with LTBP1 and Liver Diseases
 Heart Defects, Congenital Antibodies  >4 publications with LTBP1 and Heart Defects, Congenital
 Genetic Diseases, Inborn Antibodies  >4 publications with LTBP1 and Genetic Diseases, Inborn

Organs/Tissues associated with anti-LTBP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >19 publications with LTBP1 and Bone
 Vascular Antibodies  >18 publications with LTBP1 and Vascular
 Connective Tissue Antibodies  >15 publications with LTBP1 and Connective Tissue
 Lung Antibodies  >14 publications with LTBP1 and Lung
 Muscle Antibodies  >12 publications with LTBP1 and Muscle
 Heart Antibodies  >10 publications with LTBP1 and Heart
 Kidney Antibodies  >10 publications with LTBP1 and Kidney
 Embryonic Tissue Antibodies  >10 publications with LTBP1 and Embryonic Tissue
 Skin Antibodies  >9 publications with LTBP1 and Skin
 Blood Antibodies  >7 publications with LTBP1 and Blood
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