Rabbit Anti-ACCN2 Polyclonal Antibody – Cat# MBS6270855

ACCN2 Antibody – Rabbit Polyclonal

Name: ACCN2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6270855
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6270855

ACCN2 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACCN2, Polyclonal Antibody

Full Product Name

ACCN2, CT (ASIC1, ACCN2, BNAC2, Acid-sensing ion channel 1, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2) (MaxLight 550)

Product Gene Name

anti-ACCN2 antibody

Product Synonym Names

ASIC1; ACCN2; BNAC2; Acid-sensing ion channel 1; Amiloride-sensitive cation channel 2; neuronal; Brain sodium channel 2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

62,700 Da

OMIM

602866

3D Structure

ModBase 3D Structure for P78348

Immunogen

ACCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499~528 amino acids from the C-terminal region of human ACCN2.

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-ACCN2 antibody

Antibodies; Ion Channel

Applications Tested/Suitable for anti-ACCN2 antibody

Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)

Application Notes for anti-ACCN2 antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-ACCN2 antibody

Sherwood, T., et.al., J. Biol. Chem. 284 (41), 27899-27907 (2009). Kapoor, N., et.al., J. Biol. Chem. 284 (36), 24526-24541 (2009). Samways, D.S., et.al., Cell Calcium 45 (4), 319-325 (2009).

Other Notes

Small volumes of anti-ACCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACCN2 purchase

MBS6270855 is an antibody targeting ACCN2. Also known as ACCN2, CT (ASIC1, ACCN2, BNAC2, Acid-sensing ion channel 1, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACCN2. It may not necessarily be applicable to this product.

NCBI GI #

378744190

NCBI GeneID

NCBI Accession #

NP_001243759.1

UniProt Primary Accession #

P78348

UniProt Secondary Accession #

P78349; Q96CV2; A3KN86; E5KBL7

UniProt Related Accession #

P78348

GenBank Nucleotide #

NM_001256830.1

NCBI Official Full Name

acid-sensing ion channel 1 isoform c

NCBI Official Synonym Full Names

acid sensing ion channel subunit 1

NCBI Official Symbol

ASIC1

NCBI Official Synonym Symbols

ASIC; ACCN2; BNaC2

UniProt Protein Name

Acid-sensing ion channel 1

UniProt Synonym Protein Names

Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2

UniProt Gene Name

ASIC1

UniProt Synonym Gene Names

ACCN2; BNAC2; ASIC1; BNaC2

UniProt Entry Name

ASIC1_HUMAN

NCBI Protein Information

acid-sensing ion channel 1

NCBI Summary for ACCN2

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

UniProt Comments for ACCN2

Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca2+, Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear

By similarity.

Subunit structure: Homotrimer or heterotrimer with other ASIC proteins

By similarity. Interacts with STOM and ASIC2

By similarity. Interacts with PRKCABP. Ref.8 Ref.10

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Note: Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4

By similarity. Ref.10

Tissue specificity: Expressed in most or all neurons.

Post-translational modification: Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.

Miscellaneous: Potentiated by Ca2+, Mg2+, Ba2+ and multivalent cations. Inhibited by anti-inflammatory drugs like salicylic acid

By similarity. Potentiated by FMRFamide-related neuropeptides. PH dependence may be regulated by serine proteases.

Sequence similarities: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. [View classification]

Research Articles on ACCN2

1. analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACCN2 antibody

Products by Pathway	Pathway Diagram
Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies	Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies	Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ACCN2 antibody

Disease Name	Pubmed Publications
Pain Antibodies	>53 publications with ACCN2 and Pain
Brain Diseases Antibodies	>28 publications with ACCN2 and Brain Diseases
Inflammation Antibodies	>27 publications with ACCN2 and Inflammation
Brain Ischemia Antibodies	>20 publications with ACCN2 and Brain Ischemia
Disease Models, Animal Antibodies	>13 publications with ACCN2 and Disease Models, Animal
Hypertension Antibodies	>7 publications with ACCN2 and Hypertension
Anxiety Disorders Antibodies	>7 publications with ACCN2 and Anxiety Disorders
Brain Injuries Antibodies	>4 publications with ACCN2 and Brain Injuries
Fibrosis Antibodies	>3 publications with ACCN2 and Fibrosis
Seizures Antibodies	>3 publications with ACCN2 and Seizures

Organs/Tissues associated with anti-ACCN2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>73 publications with ACCN2 and Brain
Muscle Antibodies	>18 publications with ACCN2 and Muscle
Bone Antibodies	>10 publications with ACCN2 and Bone
Intestine Antibodies	>7 publications with ACCN2 and Intestine
Lung Antibodies	>6 publications with ACCN2 and Lung
Eye Antibodies	>5 publications with ACCN2 and Eye
Ovary Antibodies	>5 publications with ACCN2 and Ovary
Kidney Antibodies	>4 publications with ACCN2 and Kidney
Embryonic Tissue Antibodies	>4 publications with ACCN2 and Embryonic Tissue
Stomach Antibodies	>3 publications with ACCN2 and Stomach