Rabbit Anti-ACCN3 Polyclonal Antibody – Cat# MBS6270861

ACCN3 Antibody – Rabbit Polyclonal

Name: ACCN3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6270861
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6270861

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACCN3, Polyclonal Antibody

Full Product Name

ACCN3, NT (ASIC3, ACCN3, SLNAC1, TNAC1, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1) (Biotin)

Product Gene Name

anti-ACCN3 antibody

Product Synonym Names

ASIC3; ACCN3; SLNAC1; TNAC1; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

44,999 Da

OMIM

611741

3D Structure

ModBase 3D Structure for Q9UHC3

Immunogen

ACCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human ACCN3.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-ACCN3 antibody

Antibodies; Ion Channel

Applications Tested/Suitable for anti-ACCN3 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ACCN3 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ACCN3 antibody

Borzan, J., et al. Anesthesiology 113(3):647-654(2010). Wu, S., et al. Clin. Chim. Acta 411 (15-16), 1132-1136 (2010): Ko, Y.L., et al. J. Hypertens. 26(11):2154-2160(2008). Su, X., et al. J. Biol. Chem. 281(48):36960-36968(2006). Jones, N.G., et al. J. Neurosci. 24(48):10974-10979(2004).

Other Notes

Small volumes of anti-ACCN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACCN3 purchase

MBS6270861 is an antibody targeting ACCN3. Also known as ACCN3, NT (ASIC3, ACCN3, SLNAC1, TNAC1, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACCN3. It may not necessarily be applicable to this product.

NCBI GI #

9998948

NCBI GeneID

9311

NCBI Accession #

NP_064718.1

UniProt Primary Accession #

Q9UHC3

UniProt Secondary Accession #

O60263; O75906; Q59FN9; Q9UER8; Q9UHC4; B2R9V0

UniProt Related Accession #

Q9UHC3

GenBank Nucleotide #

NM_020322.3

NCBI Official Full Name

acid-sensing ion channel 3 isoform c

NCBI Official Synonym Full Names

acid sensing ion channel subunit 3

NCBI Official Symbol

ASIC3

NCBI Official Synonym Symbols

ACCN3; TNaC1; DRASIC; SLNAC1

UniProt Protein Name

Acid-sensing ion channel 3

UniProt Synonym Protein Names

Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1

UniProt Gene Name

ASIC3

UniProt Synonym Gene Names

ACCN3; SLNAC1; TNAC1; ASIC3; hASIC3; hTNaC1

UniProt Entry Name

ASIC3_HUMAN

NCBI Protein Information

acid-sensing ion channel 3

UniProt Comments for ACCN3

ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, integral; Channel, cation; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; enterobactin transporter activity; cation channel activity; sodium channel activity; PDZ domain binding

Biological Process: detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; transport; response to heat; sensory perception; sensory perception of sour taste; enterobactin transport; response to acidity; detection of temperature stimulus involved in sensory perception of pain; signal transduction; transmembrane transport

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACCN3 antibody

Reference Product	PubMed Publications
TRPV1 antibody	>56 publications with ACCN3 and TRPV1
PICK1 antibody	>3 publications with ACCN3 and PICK1
CFTR antibody	>2 publications with ACCN3 and CFTR
DLG4 antibody	>1 publications with ACCN3 and DLG4
LIN7B antibody	>1 publications with ACCN3 and LIN7B

Pathways associated with anti-ACCN3 antibody

Products by Pathway	Pathway Diagram
Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies	Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies	Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ACCN3 antibody

Disease Name	Pubmed Publications
Pain Antibodies	>150 publications with ACCN3 and Pain
Acidosis Antibodies	>70 publications with ACCN3 and Acidosis
Inflammation Antibodies	>54 publications with ACCN3 and Inflammation
Hyperalgesia Antibodies	>41 publications with ACCN3 and Hyperalgesia
Cardiovascular Diseases Antibodies	>22 publications with ACCN3 and Cardiovascular Diseases
Arthritis Antibodies	>10 publications with ACCN3 and Arthritis
Gastrointestinal Diseases Antibodies	>9 publications with ACCN3 and Gastrointestinal Diseases
Brain Diseases Antibodies	>7 publications with ACCN3 and Brain Diseases
Headache Antibodies	>4 publications with ACCN3 and Headache
Stroke Antibodies	>4 publications with ACCN3 and Stroke

Organs/Tissues associated with anti-ACCN3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>59 publications with ACCN3 and Brain
Muscle Antibodies	>57 publications with ACCN3 and Muscle
Blood Antibodies	>27 publications with ACCN3 and Blood
Skin Antibodies	>21 publications with ACCN3 and Skin
Eye Antibodies	>6 publications with ACCN3 and Eye
Lung Antibodies	>5 publications with ACCN3 and Lung
Embryonic Tissue Antibodies	>4 publications with ACCN3 and Embryonic Tissue
Ovary Antibodies	>4 publications with ACCN3 and Ovary
Testis Antibodies	>3 publications with ACCN3 and Testis
Uterus Antibodies	>1 publications with ACCN3 and Uterus