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NBEA Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627168

This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane… More details

$835 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NBEA, Polyclonal Antibody
Full Product Name
NBEA (Neurobeachin, BCL8B, FLJ10197, KIAA1544, Lysosomal Trafficking Regulator 2, LYST2, Protein BCL8B, Protein Neurobeachin, RP11-270C18.1)
Product Gene Name
Product Synonym Names
Anti -NBEA (Neurobeachin, BCL8B, FLJ10197, KIAA1544, Lysosomal Trafficking Regulator 2, LYST2, Protein BCL8B, Protein Neurobeachin, RP11-270C18.1)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by peptide affinity chromatography.
Specificity
Recognizes human NBEA. Species crossreactivity
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
174,573 Da
Chromosome Location
Chromosome: 13; NC_000013.10 (35516424..36246873). Location: 13q13
3D Structure
ModBase 3D Structure for Q6N008
Immunogen
Synthetic peptide corresponding to C-DFNRWHYEHQNRY, from the C Terminus of human NBEA (NP_056493.3).
Applications Tested/Suitable for anti-NBEA antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-NBEA antibody
Suitable for use in ELISA and Western Blot.
Dilution: Peptide ELISA Titer: 1:8000
Western Blot: 1-3ug/ml ~300kD band observed in lysates of transfected HEK293 and endogenously in lysates of insulinoma cell line B-TC3 (calculated MW of 327kD according to NP_056493.3). Data kindly provided by Professor John Creemers, K.U. Leuven, Belgium.

Chemiluminescence of anti-NBEA antibody

MBS627168 (1µg/ml) staining of 1) untransfected HEK293T cells 2) HEK293T cells transfected with mouse NBEA. Detected by chemiluminescence.
Goat Anti-NBEA Polyclonal Antibody – Cat# MBS627168

Other Notes

Small volumes of anti-NBEA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NBEA purchase

MBS627168 is an antibody targeting NBEA. Also known as NBEA (Neurobeachin, BCL8B, FLJ10197, KIAA1544, Lysosomal Trafficking Regulator 2, LYST2, Protein BCL8B, Protein Neurobeachin, RP11-270C18.1). Reactive in Human, Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for NBEA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neurobeachin isoform 2
NCBI Official Synonym Full Names
neurobeachin
NCBI Official Symbol
NBEA
NCBI Official Synonym Symbols
BCL8B; LYST2
UniProt Protein Name
Putative uncharacterized protein DKFZp686I03263
Protein Family
UniProt Gene Name
DKFZp686I03263
UniProt Entry Name
Q6N008_HUMAN
NCBI Protein Information
neurobeachin; OTTHUMP00000018239; lysosomal-trafficking regulator 2

NCBI Summary for NBEA

This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.
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UniProt Comments for NBEA

neurobeachin: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Belongs to the WD repeat neurobeachin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 13q13

Cellular Component: extrinsic to membrane; plasma membrane; endomembrane system; trans-Golgi network; cytosol

Molecular Function: phospholipid binding; protein kinase binding

Biological Process: protein localization; endosome transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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