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ADSS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6271969

This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ADSS, Polyclonal Antibody
Full Product Name
ADSS, CT (ADSS, ADSS2, Adenylosuccinate synthetase isozyme 2, Adenylosuccinate synthetase, acidic isozyme, Adenylosuccinate synthetase, liver isozyme, IMP-aspartate ligase 2) (PE)
Product Gene Name
anti-ADSS antibody
Product Synonym Names
ADSS; ADSS2; Adenylosuccinate synthetase isozyme 2; Adenylosuccinate synthetase; acidic isozyme; Adenylosuccinate synthetase; liver isozyme; IMP--aspartate ligase 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
50,097 Da
OMIM
103060
3D Structure
ModBase 3D Structure for P30520
Immunogen
ADSS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 amino acids from the C-terminal region of human ADSS.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-ADSS antibody

Antibodies; Enzymes; Synthase
Applications Tested/Suitable for anti-ADSS antibody
Western Blot (WB), FLISA
Application Notes for anti-ADSS antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ADSS antibody

ADSS Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ADSS antibody detected the ADSS protein (arrow).
Rabbit Anti-ADSS Polyclonal Antibody – Cat# MBS6271969

Product References and Citations for anti-ADSS antibody

Sivendran, S., et al. Protein Sci. 17(7):1162-1174(2008). Zhang, F., et al. BMC Med. Genet. 9, 119 (2008): Zhang, F., et al. Behav Brain Funct 4, 39 (2008): Sun, H., et al. Mol. Cell. Biochem. 269 (1-2), 85-94 (2005): Stepinski, J., et al. Kidney Int. 50(4):1195-1201(1996).

Other Notes

Small volumes of anti-ADSS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADSS purchase

MBS6271969 is an antibody targeting ADSS. Also known as ADSS, CT (ADSS, ADSS2, Adenylosuccinate synthetase isozyme 2, Adenylosuccinate synthetase, acidic isozyme, Adenylosuccinate synthetase, liver isozyme, IMP-aspartate ligase 2) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADSS. It may not necessarily be applicable to this product.

NCBI GI #
34577063
NCBI GeneID
159
NCBI Accession #
NP_001117.2
UniProt Primary Accession #
P30520
UniProt Secondary Accession #
Q96EG7; B1AQM5
UniProt Related Accession #
P30520
GenBank Nucleotide #
NM_001126.3
NCBI Official Full Name
adenylosuccinate synthetase isozyme 2
NCBI Official Synonym Full Names
adenylosuccinate synthase
NCBI Official Symbol
ADSS
NCBI Official Synonym Symbols
ADEH; ADSS 2
UniProt Protein Name
Adenylosuccinate synthetase isozyme 2
UniProt Synonym Protein Names
Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2
Protein Family
Adenylosuccinate synthetase
UniProt Gene Name
ADSS
UniProt Entry Name
PURA2_HUMAN
NCBI Protein Information
adenylosuccinate synthetase isozyme 2; AMPSase 2; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase; adenylosuccinate synthetase, liver isozyme; adenylosuccinate synthetase, acidic isozyme; adenylosuccinate synthetase (Ade(-)H-complementing)

UniProt Comments for ADSS

ADSS: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family.

Protein type: EC 6.3.4.4; Nucleotide Metabolism - purine; Amino Acid Metabolism - alanine, aspartate and glutamate; Ligase

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; GTP binding; magnesium ion binding; adenylosuccinate synthase activity; phosphate binding

Biological Process: AMP biosynthetic process; response to purine; purine ribonucleoside monophosphate biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; immune system process; IMP metabolic process; aspartate metabolic process; purine base metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADSS antibody

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-ADSS antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >10 publications with ADSS and Mental Disorders
 Drug Toxicity Antibodies  >6 publications with ADSS and Drug Toxicity
 Necrosis Antibodies  >3 publications with ADSS and Necrosis
 Liver Diseases Antibodies  >2 publications with ADSS and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with ADSS and Nervous System Diseases
 Neoplasms Antibodies  >1 publications with ADSS and Neoplasms
 Heart Diseases Antibodies  >1 publications with ADSS and Heart Diseases
 Anemia Antibodies  >1 publications with ADSS and Anemia
 Brain Diseases Antibodies  >1 publications with ADSS and Brain Diseases
 Hyperplasia Antibodies  >1 publications with ADSS and Hyperplasia

Organs/Tissues associated with anti-ADSS antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >10 publications with ADSS and Lung
 Blood Antibodies  >9 publications with ADSS and Blood
 Muscle Antibodies  >7 publications with ADSS and Muscle
 Heart Antibodies  >4 publications with ADSS and Heart
 Liver Antibodies  >4 publications with ADSS and Liver
 Bone Antibodies  >3 publications with ADSS and Bone
 Brain Antibodies  >3 publications with ADSS and Brain
 Ovary Antibodies  >2 publications with ADSS and Ovary
 Trachea Antibodies  >1 publications with ADSS and Trachea
 Bladder Antibodies  >1 publications with ADSS and Bladder
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