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CCR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627260

CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5).… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CCR3, Polyclonal Antibody
Full Product Name
CCR3, ID (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor, CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)
Product Gene Name
anti-CCR3 antibody
Product Synonym Names
Anti -CCR3, ID (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor, CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CCR3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,044 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (46283872..46308197). Location: 3p21.3
OMIM
601268
3D Structure
ModBase 3D Structure for P51677
Immunogen
Synthetic peptide selected from the Center region of human CCR3 (KLH).

Product Categories/Family for anti-CCR3 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-CCR3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CCR3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-CCR3 antibody

Western blot analysis of CCR3 Antibody (Center) in Jurkat cell line lysates (35ug/lane). CCR3 (arrow) was detected using the purified Pab.
Rabbit Anti-CCR3 Polyclonal Antibody – Cat# MBS627260

Flow Cytometry (FC/FACS) of anti-CCR3 antibody

CCR3 Antibody (Center) flow cytometry analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CCR3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS627260

Other Notes

Small volumes of anti-CCR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCR3 purchase

MBS627260 is an antibody targeting CCR3. Also known as CCR3, ID (CD193, CC Chemokine Receptor Type 3, CC CKR 3, CC CKR3, B Chemokine Receptor, CMKBR3, Eosinophil CC Chemokine Receptor 3, Eosinophil Eotaxin Receptor, MGC102841). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR3. It may not necessarily be applicable to this product.

NCBI GI #
257743046
NCBI GeneID
1232
NCBI Accession #
NP_847898.1
UniProt Primary Accession #
P51677
UniProt Secondary Accession #
Q15748; Q2YDB9; Q86WD2; Q9ULY8; B3KVQ1
UniProt Related Accession #
P51677; Q8TDP4; Q8TDP5; Q8TDP6; Q8TDP7; Q8TDP8; Q96T96; Q96T97
GenBank Nucleotide #
NM_178328.1
NCBI Official Full Name
C-C chemokine receptor type 3 isoform 2
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 3
NCBI Official Symbol
CCR3
NCBI Official Synonym Symbols
CKR3; CD193; CMKBR3; CC-CKR-3; MGC102841
UniProt Protein Name
C-C chemokine receptor type 3
UniProt Synonym Protein Names
Eosinophil eotaxin receptor
Protein Family
C-C chemokine receptor
UniProt Gene Name
CCR3
UniProt Synonym Gene Names
CMKBR3
UniProt Entry Name
CCR3_HUMAN
NCBI Protein Information
C-C chemokine receptor type 3; CCR-3; C-C CKR-3; OTTHUMP00000209745; b-chemokine receptor; CC chemokine receptor 3; eosinophil eotaxin receptor; eosinophil CC chemokine receptor 3

NCBI Summary for CCR3

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq]
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UniProt Comments for CCR3

CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, cytokine; Motility/polarity/chemotaxis; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; viral reproduction; cellular defense response; positive regulation of endothelial cell proliferation; cell adhesion; inflammatory response; chemotaxis
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Research Articles on CCR3

1. Leucocyte of children with infectious mononucleosis expressed higher level of CCR3 and lower level of CCR5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR3 antibody

 Reference Product  PubMed Publications
 CCL11 antibody  >299 publications with CCR3 and CCL11
 CCL5 antibody  >179 publications with CCR3 and CCL5
 CCL24 antibody  >80 publications with CCR3 and CCL24
 CCL3 antibody  >62 publications with CCR3 and CCL3
 CCL26 antibody  >56 publications with CCR3 and CCL26
 CXCL10 antibody  >44 publications with CCR3 and CXCL10
 CCL7 antibody  >41 publications with CCR3 and CCL7
 CCL13 antibody  >29 publications with CCR3 and CCL13
 CXCL9 antibody  >27 publications with CCR3 and CXCL9
 CCL14 antibody  >15 publications with CCR3 and CCL14

Pathways associated with anti-CCR3 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CCR3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >303 publications with CCR3 and Inflammation
 Hypersensitivity Antibodies  >229 publications with CCR3 and Hypersensitivity
 Asthma Antibodies  >208 publications with CCR3 and Asthma
 Lung Diseases Antibodies  >169 publications with CCR3 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >143 publications with CCR3 and Respiratory Hypersensitivity
 HIV Infections Antibodies  >119 publications with CCR3 and HIV Infections
 Eosinophilia Antibodies  >93 publications with CCR3 and Eosinophilia
 Neoplasms Antibodies  >66 publications with CCR3 and Neoplasms
 Dermatitis, Atopic Antibodies  >36 publications with CCR3 and Dermatitis, Atopic
 Rhinitis Antibodies  >30 publications with CCR3 and Rhinitis

Organs/Tissues associated with anti-CCR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >727 publications with CCR3 and Blood
 Connective Tissue Antibodies  >11 publications with CCR3 and Connective Tissue
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