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AKT3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6272687

AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including… More details

$1060 / 0.2 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AKT3, Polyclonal Antibody
Full Product Name
AKT3, ID (AKT3, PKBG, RAC-gamma serine/threonine-protein kinase, Protein kinase Akt-3, Protein kinase B gamma, RAC-PK-gamma, STK-2) (Biotin)
Product Gene Name
anti-AKT3 antibody
Product Synonym Names
AKT3; PKBG; RAC-gamma serine/threonine-protein kinase; Protein kinase Akt-3; Protein kinase B gamma; RAC-PK-gamma; STK-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human AKT3. Species Crossreactivity: monkey, mouse and rat
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,775 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (243651535..244006886, complement). Location: 1q44
OMIM
603387
3D Structure
ModBase 3D Structure for Q9Y243
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 88-118 in the central region of human AKT3, UniProt Accession #Q9Y243.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-AKT3 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-AKT3 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-AKT3 antibody
IHC: 1:50-100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-AKT3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted withMBS6002293, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
Rabbit Anti-AKT3 Polyclonal Antibody – Cat# MBS6272687

Western Blot (WB) of anti-AKT3 antibody

Western Blot analysis of lysate from Jurkat cell line, usingMBS6002293. MBS6002293 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane.
Rabbit Anti-AKT3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6272687

Other Notes

Small volumes of anti-AKT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKT3 purchase

MBS6272687 is an antibody targeting AKT3. Also known as AKT3, ID (AKT3, PKBG, RAC-gamma serine/threonine-protein kinase, Protein kinase Akt-3, Protein kinase B gamma, RAC-PK-gamma, STK-2) (Biotin). Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AKT3. It may not necessarily be applicable to this product.

NCBI GI #
4757579
NCBI GeneID
10000
NCBI Accession #
AAD29089.1
UniProt Primary Accession #
Q9Y243
UniProt Secondary Accession #
Q0VAA6; Q5VTI1; Q5VTI2; Q96QV3; Q9UFP5
UniProt Related Accession #
Q9Y243
NCBI Official Full Name
protein kinase B gamma
NCBI Official Synonym Full Names
v-akt murine thymoma viral oncogene homolog 3
NCBI Official Symbol
AKT3
NCBI Official Synonym Symbols
MPPH; PKBG; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma
UniProt Protein Name
RAC-gamma serine/threonine-protein kinase
UniProt Synonym Protein Names
Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2
Protein Family
RAC-gamma serine/threonine-protein kinase
UniProt Gene Name
AKT3
UniProt Synonym Gene Names
PKBG; PKB gamma
UniProt Entry Name
AKT3_HUMAN
NCBI Protein Information
RAC-gamma serine/threonine-protein kinase; PKB gamma; RAC-gamma serine/threonine protein kinase; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

NCBI Summary for AKT3

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKT3

Akt3: an AGC kinase that plays a critical role in controlling the balance between survival and apoptosis. Stimulated by platelet-derived growth factor, insulin, and insulin-like growth factor 1. Alternatively spliced isoforms have been described.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; plasma membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity

Biological Process: mitochondrial genome maintenance; signal transduction; protein amino acid phosphorylation

Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus Syndrome 2
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Research Articles on AKT3

1. AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AKT3 antibody

 Reference Product  PubMed Publications
 PTEN antibody  >50 publications with AKT3 and PTEN
 MTOR antibody  >27 publications with AKT3 and MTOR
 PIK3CA antibody  >20 publications with AKT3 and PIK3CA
 VEGFA antibody  >4 publications with AKT3 and VEGFA
 PDPK1 antibody  >2 publications with AKT3 and PDPK1
 TSC2 antibody  >2 publications with AKT3 and TSC2
 FLT1 antibody  >1 publications with AKT3 and FLT1

Pathways associated with anti-AKT3 antibody

 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AKT-mediated Inactivation Of FOXO1A Pathway antibodies  AKT-mediated Inactivation Of FOXO1A Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram

Diseases associated with anti-AKT3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >130 publications with AKT3 and Neoplasms
 Breast Neoplasms Antibodies  >32 publications with AKT3 and Breast Neoplasms
 Nervous System Diseases Antibodies  >29 publications with AKT3 and Nervous System Diseases
 Brain Diseases Antibodies  >18 publications with AKT3 and Brain Diseases
 Ovarian Neoplasms Antibodies  >16 publications with AKT3 and Ovarian Neoplasms
 Congenital Abnormalities Antibodies  >15 publications with AKT3 and Congenital Abnormalities
 Skin Neoplasms Antibodies  >14 publications with AKT3 and Skin Neoplasms
 Lung Neoplasms Antibodies  >12 publications with AKT3 and Lung Neoplasms
 Gastrointestinal Diseases Antibodies  >11 publications with AKT3 and Gastrointestinal Diseases
 Necrosis Antibodies  >8 publications with AKT3 and Necrosis

Organs/Tissues associated with anti-AKT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with AKT3 and Blood
 Brain Antibodies  >39 publications with AKT3 and Brain
 Muscle Antibodies  >30 publications with AKT3 and Muscle
 Vascular Antibodies  >26 publications with AKT3 and Vascular
 Skin Antibodies  >22 publications with AKT3 and Skin
 Prostate Antibodies  >15 publications with AKT3 and Prostate
 Lung Antibodies  >15 publications with AKT3 and Lung
 Bone Antibodies  >12 publications with AKT3 and Bone
 Liver Antibodies  >11 publications with AKT3 and Liver
 Embryonic Tissue Antibodies  >9 publications with AKT3 and Embryonic Tissue
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