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ALOXE3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6273043

ALOXE3 is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ALOXE3, Polyclonal Antibody
Full Product Name
ALOXE3, ID (ALOXE3, Epidermis-type lipoxygenase 3) (MaxLight 490)
Product Gene Name
anti-ALOXE3 antibody
Product Synonym Names
ALOXE3; Epidermis-type lipoxygenase 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
Observed MW: 81kDa
Calculated MW: 80kDa/95kDa
OMIM
606545
3D Structure
ModBase 3D Structure for Q9BYJ1
Immunogen
ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the Central region of human ALOXE3.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-ALOXE3 antibody

Antibodies; Leukotrienes
Applications Tested/Suitable for anti-ALOXE3 antibody
Western Blot (WB), FLISA
Application Notes for anti-ALOXE3 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ALOXE3 antibody

Han, S., et al. Hum. Immunol. 71(7):727-730(2010). Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010). Vahlquist, A., et al. J. Invest. Dermatol. 130(2):438-443(2010). Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009). Yu, Z., et al. Lipids 42(6):491-497(2007).

Other Notes

Small volumes of anti-ALOXE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALOXE3 purchase

MBS6273043 is an antibody targeting ALOXE3. Also known as ALOXE3, ID (ALOXE3, Epidermis-type lipoxygenase 3) (MaxLight 490). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOXE3. It may not necessarily be applicable to this product.

NCBI GI #
260166612
NCBI GeneID
59344
NCBI Accession #
NP_067641.2
NCBI Related Accession #
NP_001159432.1
UniProt Primary Accession #
Q9BYJ1
UniProt Secondary Accession #
Q3ZB74; Q9H4F2; Q9HC22; B2R981; B7Z3W0
UniProt Related Accession #
Q9BYJ1
GenBank Nucleotide #
NM_001165960.1
NCBI Official Full Name
hydroperoxide isomerase ALOXE3 isoform 1
NCBI Official Synonym Full Names
arachidonate lipoxygenase 3
NCBI Official Symbol
ALOXE3
NCBI Official Synonym Symbols
ARCI3; E-LOX; eLOX3; eLOX-3
UniProt Protein Name
Hydroperoxide isomerase ALOXE3
UniProt Synonym Protein Names
Epidermis-type lipoxygenase 3; Epidermal LOX-3; e-LOX-3; eLOX-3; Hydroperoxy icosatetraenoate dehydratase (EC:4.2.1.152)
Protein Family
Hydroperoxide isomerase
UniProt Gene Name
ALOXE3
UniProt Synonym Gene Names
Epidermal LOX-3; e-LOX-3; eLOX-3
UniProt Entry Name
LOXE3_HUMAN
NCBI Protein Information
hydroperoxide isomerase ALOXE3

NCBI Summary for ALOXE3

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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Research Articles on ALOXE3

1. Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALOXE3 antibody

 Reference Product  PubMed Publications
 LOX antibody  >18 publications with ALOXE3 and LOX
 ABCA12 antibody  >6 publications with ALOXE3 and ABCA12
 CYP4F22 antibody  >5 publications with ALOXE3 and CYP4F22
 NIPAL4 antibody  >4 publications with ALOXE3 and NIPAL4
 HES7 antibody  >1 publications with ALOXE3 and HES7

Diseases associated with anti-ALOXE3 antibody

 Disease Name  Pubmed Publications
 Ichthyosis, Lamellar Antibodies  >10 publications with ALOXE3 and Ichthyosis, Lamellar
 Inflammation Antibodies  >3 publications with ALOXE3 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with ALOXE3 and Disease Models, Animal
 Brain Diseases Antibodies  >1 publications with ALOXE3 and Brain Diseases
 Fatty Liver Antibodies  >1 publications with ALOXE3 and Fatty Liver

Organs/Tissues associated with anti-ALOXE3 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >24 publications with ALOXE3 and Skin
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