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HRH3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627344

HRH3 is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the CNS and PNS. The deduced 445aa HRH3 protein contains 7 predicted transmembrane domains. HRH3 has significant… More details

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Product Overview

Online Datasheet in PDF
Product Name
HRH3, Polyclonal Antibody
Full Product Name
HRH3, CT (Histamine H3 Receptor, HH3R, G-protein Coupled Receptor 97, HRH3, GPCR97)
Product Gene Name
anti-Hrh3 antibody
Product Synonym Names
Anti -HRH3, CT (Histamine H3 Receptor, HH3R, G-protein Coupled Receptor 97, HRH3, GPCR97)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human HRH3 at ~50kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,588 Da
Chromosome Location
Chromosome: 3; NC_005102.3 (181639287..181644371). Location: 3q43
3D Structure
ModBase 3D Structure for Q9QYN8
Immunogen
Synthetic peptide corresponding to aa416-445 from the C-terminal region of human HRH3 conjugated to KLH (Q9Y5N1). Cellular Location: Cell Membrane

Product Categories/Family for anti-Hrh3 antibody

Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-Hrh3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Hrh3 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:100-1:500
Immunohistochemistry (FFPE): 1:10-1:50

Western Blot (WB) of anti-Hrh3 antibody

Western blot analysis of anti-HH3R Pab (Rabbit ID 1071) in Jurkat cell line lysate (35ug/lane). HH3R(arrow) was detected using the purified Pab. This western blot identifies isoform two of HRH3. The accession number of HRH3 is CAC39434; Q9Y5N1.
Rabbit Anti-HRH3 Polyclonal Antibody – Cat# MBS627344

Immunohistochemistry (IHC) of anti-Hrh3 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with HRH3 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-HRH3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627344

Other Notes

Small volumes of anti-Hrh3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hrh3 purchase

MBS627344 is an antibody targeting Hrh3. Also known as HRH3, CT (Histamine H3 Receptor, HH3R, G-protein Coupled Receptor 97, HRH3, GPCR97). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Hrh3. It may not necessarily be applicable to this product.

NCBI GI #
396080303
NCBI GeneID
85268
NCBI Accession #
NP_001257499.1
UniProt Primary Accession #
Q9QYN8
UniProt Secondary Accession #
Q9QYN6; Q9QYN7; Q9QYN9
UniProt Related Accession #
Q9QYN8
GenBank Nucleotide #
NM_001270570.1
NCBI Official Full Name
histamine H3 receptor isoform 8
NCBI Official Synonym Full Names
histamine receptor H3
NCBI Official Symbol
Hrh3
UniProt Protein Name
Histamine H3 receptor
Protein Family
Histamine H3 receptor
UniProt Gene Name
Hrh3
UniProt Synonym Gene Names
H3R; HH3R
UniProt Entry Name
HRH3_RAT
NCBI Protein Information
histamine H3 receptor; H3R; HH3R

NCBI Summary for Hrh3

This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]
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UniProt Comments for Hrh3

H3R: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: neuron projection; integral to membrane; plasma membrane; myelin sheath

Molecular Function: drug binding; histamine receptor activity

Biological Process: negative regulation of glutamate secretion; eating behavior; regulation of neurotransmitter levels; negative regulation of gamma-aminobutyric acid secretion; negative regulation of adenylate cyclase activity; drinking behavior; learning; regulation of norepinephrine secretion; response to organic cyclic substance; memory; G-protein coupled receptor protein signaling pathway; negative regulation of serotonin secretion; elevation of cytosolic calcium ion concentration; brain development; negative regulation of blood pressure; cognition; positive regulation of epithelial cell proliferation
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Research Articles on Hrh3

1. ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Hrh3 antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Histamine Receptors Pathway antibodies  Histamine Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-Hrh3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with Hrh3 and Inflammation
 Neoplasms Antibodies  >2 publications with Hrh3 and Neoplasms
 Neurologic Manifestations Antibodies  >2 publications with Hrh3 and Neurologic Manifestations
 Neurodegenerative Diseases Antibodies  >2 publications with Hrh3 and Neurodegenerative Diseases
 Cardiovascular Diseases Antibodies  >2 publications with Hrh3 and Cardiovascular Diseases
 Respiratory Hypersensitivity Antibodies  >1 publications with Hrh3 and Respiratory Hypersensitivity
 Edema Antibodies  >1 publications with Hrh3 and Edema

Organs/Tissues associated with anti-Hrh3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with Hrh3 and Brain
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