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CBX4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627364

CBX4 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer.… More details

$895 / 0.2 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CBX4, Polyclonal Antibody
Full Product Name
CBX4, NT (E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Polycomb 2 Homolog, Pc2, hPc2)
Product Gene Name
anti-CBX4 antibody
Product Synonym Names
Anti -CBX4, NT (E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Polycomb 2 Homolog, Pc2, hPc2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CBX4. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
61,368 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (77806955..77813213, complement). Location: 17q25.3
OMIM
603079
3D Structure
ModBase 3D Structure for O00257
Immunogen
Synthetic peptide selected from the N-terminal region of human CBX4 (KLH).

Product Categories/Family for anti-CBX4 antibody

Antibodies; Abs to Chromatin Proteins
Applications Tested/Suitable for anti-CBX4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CBX4 antibody
Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-CBX4 antibody

Western Blot using MBS627364 to detect CBX4 in mouse kidney tissue lysate.
Rabbit Anti-CBX4 Polyclonal Antibody – Cat# MBS627364

Immunohistochemistry (IHC) of anti-CBX4 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MBS627364 which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
Rabbit Anti-CBX4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627364

Other Notes

Small volumes of anti-CBX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBX4 purchase

MBS627364 is an antibody targeting CBX4. Also known as CBX4, NT (E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Polycomb 2 Homolog, Pc2, hPc2). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CBX4. It may not necessarily be applicable to this product.

NCBI GI #
15929016
NCBI GeneID
8535
UniProt Primary Accession #
O00257
UniProt Secondary Accession #
Q6TPI8; Q96C04
UniProt Related Accession #
O00257; Q6TPI8
NCBI Official Full Name
CBX4 protein
NCBI Official Synonym Full Names
chromobox homolog 4
NCBI Official Symbol
CBX4
NCBI Official Synonym Symbols
PC2; NBP16
UniProt Protein Name
E3 SUMO-protein ligase CBX4
UniProt Synonym Protein Names
Chromobox protein homolog 4; Polycomb 2 homolog
Protein Family
E3 SUMO-protein ligase
UniProt Gene Name
CBX4
UniProt Entry Name
CBX4_HUMAN
NCBI Protein Information
E3 SUMO-protein ligase CBX4; OTTHUMP00000197308; OTTHUMP00000197309; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox protein homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila)

UniProt Comments for CBX4

CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; SUMO ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; nuclear speck; PcG protein complex; nucleus

Molecular Function: protein binding; enzyme binding; single-stranded RNA binding; SUMO binding; phosphoprotein binding; chromatin binding; transcription corepressor activity; methylated histone residue binding; ligase activity

Biological Process: protein sumoylation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Research Articles on CBX4

1. the hPc2-induced SUMOylation of alpha-synuclein could function as a cytoprotector by increasing alpha-synuclein aggregate formation within fibroblast cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBX4 antibody

 Reference Product  PubMed Publications
 RNF2 antibody  >2 publications with CBX4 and RNF2
 RING1 antibody  >2 publications with CBX4 and RING1
 PHC1 antibody  >1 publications with CBX4 and PHC1
 SUMO1 antibody  >1 publications with CBX4 and SUMO1
 CTBP1 antibody  >1 publications with CBX4 and CTBP1

Pathways associated with anti-CBX4 antibody

 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
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