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KHSRP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627398

KHSRP binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). It is a part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are… More details

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Product Overview

Online Datasheet in PDF
Product Name
KHSRP, Polyclonal Antibody
Full Product Name
KHSRP, NT (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75)
Product Gene Name
anti-KHSRP antibody
Product Synonym Names
Anti -KHSRP, NT (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human KHSRP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
73,115 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (6413115..6424822, complement). Location: 19p13.3
OMIM
603445
3D Structure
ModBase 3D Structure for Q92945
Immunogen
Synthetic peptide selected from the N-terminal region of human KHSRP (KLH).

Product Categories/Family for anti-KHSRP antibody

Antibodies; Abs to RNA Processing
Applications Tested/Suitable for anti-KHSRP antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KHSRP antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-KHSRP antibody

Western blot analysis of KHSRP Antibody (N-term) in T47D cell line lysates (35ug/lane). KHSRP (arrow) was detected using the purified Pab.
Rabbit Anti-KHSRP Polyclonal Antibody – Cat# MBS627398

Immunohistochemistry (IHC) of anti-KHSRP antibody

Formalin-fixed and paraffin-embedded human brain with KHSRP Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-KHSRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627398

Immunofluorescence (IF) of anti-KHSRP antibody

Immunofluorescence analysis of KHSRP Antibody (N-term) with paraffin-embedded human brain tissue . 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence.
Rabbit Anti-KHSRP Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS627398

Other Notes

Small volumes of anti-KHSRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KHSRP purchase

MBS627398 is an antibody targeting KHSRP. Also known as KHSRP, NT (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KHSRP. It may not necessarily be applicable to this product.

NCBI GI #
54648253
NCBI GeneID
8570
UniProt Primary Accession #
Q92945
UniProt Secondary Accession #
O00301; Q59EZ9; Q5U4P6; Q9UNT5; Q9UQH5
UniProt Related Accession #
Q92945
NCBI Official Full Name
KHSRP protein
NCBI Official Synonym Full Names
KH-type splicing regulatory protein
NCBI Official Symbol
KHSRP
NCBI Official Synonym Symbols
FBP2; KSRP; FUBP2; MGC99676
UniProt Protein Name
Far upstream element-binding protein 2
UniProt Synonym Protein Names
KH type-splicing regulatory protein; KSRP; p75
Protein Family
Far upstream element-binding protein
UniProt Gene Name
KHSRP
UniProt Synonym Gene Names
FUBP2
UniProt Entry Name
FUBP2_HUMAN
NCBI Protein Information
far upstream element-binding protein 2; p75; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein

NCBI Summary for KHSRP

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM]

UniProt Comments for KHSRP

KHSRP: an RNA binding and processing protein that binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' untranslated regions, possibly by recruiting degradation machinery to ARE-containing mRNAs. Interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; membrane; stress granule; cytosol

Molecular Function: mRNA binding; DNA binding

Biological Process: RNA splicing, via transesterification reactions; mRNA transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; mRNA catabolic process; gene expression; mRNA processing
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Research Articles on KHSRP

1. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation (REVIEW)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KHSRP antibody

 Reference Product  PubMed Publications
 FOS antibody  >2 publications with KHSRP and FOS
 PARN antibody  >1 publications with KHSRP and PARN
 JUN antibody  >1 publications with KHSRP and JUN

Pathways associated with anti-KHSRP antibody

 Products by Pathway  Pathway Diagram
 Destabilization Of MRNA By KSRP Pathway antibodies  Destabilization Of MRNA By KSRP Pathway Diagram
 Metabolism Of RNA Pathway antibodies  Metabolism Of RNA Pathway Diagram
 Metabolism Of MRNA Pathway antibodies  Metabolism Of MRNA Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram

Diseases associated with anti-KHSRP antibody

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >3 publications with KHSRP and Neurodegenerative Diseases
 Neuroblastoma Antibodies  >2 publications with KHSRP and Neuroblastoma
 Kidney Failure, Chronic Antibodies  >2 publications with KHSRP and Kidney Failure, Chronic
 Genetic Diseases, Inborn Antibodies  >2 publications with KHSRP and Genetic Diseases, Inborn
 Kidney Diseases Antibodies  >2 publications with KHSRP and Kidney Diseases
 Carcinoma Antibodies  >1 publications with KHSRP and Carcinoma
 Congenital Abnormalities Antibodies  >1 publications with KHSRP and Congenital Abnormalities
 Renal Insufficiency Antibodies  >1 publications with KHSRP and Renal Insufficiency
 Mitochondrial Diseases Antibodies  >1 publications with KHSRP and Mitochondrial Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with KHSRP and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-KHSRP antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with KHSRP and Liver
 Brain Antibodies  >6 publications with KHSRP and Brain
 Nerve Antibodies  >4 publications with KHSRP and Nerve
 Blood Antibodies  >4 publications with KHSRP and Blood
 Muscle Antibodies  >3 publications with KHSRP and Muscle
 Bone Antibodies  >2 publications with KHSRP and Bone
 Kidney Antibodies  >2 publications with KHSRP and Kidney
 Ganglia Antibodies  >1 publications with KHSRP and Ganglia
 Lung Antibodies  >1 publications with KHSRP and Lung
 Eye Antibodies  >1 publications with KHSRP and Eye
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