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CFHR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627430

CFHL1 might be involved in complement regulation. The protein can associate with lipoproteins and may play a role in lipid metabolism. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CFHR1, Polyclonal Antibody
Full Product Name
CFHR1, CT (Complement Factor H-related Protein 1, FHR-1, H Factor-like Protein 1, H-Factor-like 1, H36, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2)
Product Gene Name
Product Synonym Names
Anti -CFHR1, CT (Complement Factor H-related Protein 1, FHR-1, H Factor-like Protein 1, H-Factor-like 1, H36, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CFHL1 at ~37kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,651 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (196788861..196801319). Location: 1q32
OMIM
134371
3D Structure
ModBase 3D Structure for Q03591
Immunogen
Synthetic peptide corresponding to a portion of amino acids within aa276-306 from the C-terminal region of human CFHL1 (KLH)

Product Categories/Family for anti-CFHR1 antibody

Applications Tested/Suitable for anti-CFHR1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-CFHR1 antibody
Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:1000
Flow Cytometry: 1:10-1:50
Immunohistochemistry: 1:50-1:100
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CFHR1 antibody

Western blot analysis of CFHL1 antibody (C-term) in K562 cell line lysates (35ug/lane). CFHL1 (arrow) was detected using the purified Pab.
Rabbit Anti-CFHR1 Polyclonal Antibody – Cat# MBS627430

Immunohistochemistry (IHC) of anti-CFHR1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma with CFHL1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CFHR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627430

Flow Cytometry (FC/FACS) of anti-CFHR1 antibody

Flow cytometric analysis of K562 cells using CFHL1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CFHR1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS627430

Other Notes

Small volumes of anti-CFHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFHR1 purchase

MBS627430 is an antibody targeting CFHR1. Also known as CFHR1, CT (Complement Factor H-related Protein 1, FHR-1, H Factor-like Protein 1, H-Factor-like 1, H36, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CFHR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
complement factor H-related protein 1
NCBI Official Synonym Full Names
complement factor H-related 1
NCBI Official Symbol
CFHR1
NCBI Official Synonym Symbols
CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P; MGC104329
UniProt Protein Name
Complement factor H-related protein 1
UniProt Synonym Protein Names
H factor-like protein 1; H-factor-like 1; H36
UniProt Gene Name
CFHR1
UniProt Synonym Gene Names
CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2
UniProt Entry Name
FHR1_HUMAN
NCBI Protein Information
complement factor H-related protein 1; H36; FHR-1; H-factor-like 1; OTTHUMP00000034408; OTTHUMP00000034409; h factor-like protein 1; H factor (complement)-like 1; H factor (complement)-like 2; complement factor H-related 1 pseudogene

NCBI Summary for CFHR1

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq]
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UniProt Comments for CFHR1

CFHR1: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space

Biological Process: complement activation

Disease: Macular Degeneration, Age-related, 1; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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