Rabbit Anti-ARHGEF11 Polyclonal Antibody – Cat# MBS6274957

ARHGEF11 Antibody – Rabbit Polyclonal

Name: ARHGEF11 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6274957
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6274957

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ARHGEF11, Polyclonal Antibody

Full Product Name

ARHGEF11, ID (ARHGEF11, KIAA0380, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF) (MaxLight 490)

Product Gene Name

anti-ARHGEF11 antibody

Product Synonym Names

ARHGEF11; KIAA0380; Rho guanine nucleotide exchange factor 11; PDZ-RhoGEF

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

167,704 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (156904632..157015162, complement). Location: 1q21

OMIM

605708

3D Structure

ModBase 3D Structure for O15085

Immunogen

ARHGEF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 604-632 amino acids from the Central region of human ARHGEF11.

Conjugate

MaxLight490

Note

Preservative Free

Product Categories/Family for anti-ARHGEF11 antibody

Antibodies; PDZ Domain

Applications Tested/Suitable for anti-ARHGEF11 antibody

Western Blot (WB), FLISA

Application Notes for anti-ARHGEF11 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ARHGEF11 antibody

Akiyama, K., et al. J. Hum. Genet. (2010). In press: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Ying, Z., et al. Arterioscler. Thromb. Vasc. Biol. 29(10):1657-1663(2009). Banerjee, J., et al. Biochemistry 48(33):8032-8043(2009). Zheng, M., et al. BMC Struct. Biol. 9, 36 (2009).

Other Notes

Small volumes of anti-ARHGEF11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARHGEF11 purchase

MBS6274957 is an antibody targeting ARHGEF11. Also known as ARHGEF11, ID (ARHGEF11, KIAA0380, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF) (MaxLight 490). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF11. It may not necessarily be applicable to this product.

NCBI GI #

7662086

NCBI GeneID

9826

NCBI Accession #

NP_055599.1

UniProt Primary Accession #

O15085

UniProt Secondary Accession #

Q5VY40; Q6PFW2; D3DVD0

UniProt Related Accession #

O15085

GenBank Nucleotide #

NM_014784.3

NCBI Official Full Name

rho guanine nucleotide exchange factor 11 isoform 1

NCBI Official Synonym Full Names

Rho guanine nucleotide exchange factor (GEF) 11

NCBI Official Symbol

ARHGEF11

NCBI Official Synonym Symbols

GTRAP48; PDZ-RHOGEF

UniProt Protein Name

Rho guanine nucleotide exchange factor 11

UniProt Synonym Protein Names

PDZ-RhoGEF

Protein Family

Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF11

UniProt Synonym Gene Names

KIAA0380

UniProt Entry Name

ARHGB_HUMAN

NCBI Protein Information

rho guanine nucleotide exchange factor 11; Rho guanine exchange factor (GEF) 11; RhoGEF glutamate transport modulator; RhoA-specific guanine nucleotide exchange factor; glutamate transporter EAAT4-associated protein 48

UniProt Comments for ARHGEF11

ARHGEF11: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: membrane; cytoplasm; intracellular; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; G-protein-coupled receptor binding; GTPase activator activity

Biological Process: axon guidance; striated muscle contraction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; cytokinesis; Rho protein signal transduction; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; establishment of cell polarity; small GTPase mediated signal transduction; regulation of cell growth; actin cytoskeleton organization and biogenesis; cell motility

Research Articles on ARHGEF11

1. analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARHGEF11 antibody

Reference Product	PubMed Publications
RHOA antibody	>15 publications with ARHGEF11 and RHOA
PLXNB1 antibody	>3 publications with ARHGEF11 and PLXNB1
SLC1A6 antibody	>1 publications with ARHGEF11 and SLC1A6
ABCA1 antibody	>1 publications with ARHGEF11 and ABCA1

Pathways associated with anti-ARHGEF11 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
G Alpha (12/13) Signalling Events Pathway antibodies	G Alpha (12/13) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
NRAGE Signals Death Through JNK Pathway antibodies	NRAGE Signals Death Through JNK Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram
Rho GTPase Cycle Pathway antibodies	Rho GTPase Cycle Pathway Diagram
Sema4D In Semaphorin Signaling Pathway antibodies	Sema4D In Semaphorin Signaling Pathway Diagram
Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies	Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram

Diseases associated with anti-ARHGEF11 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with ARHGEF11 and Neoplasms
Lung Neoplasms Antibodies	>1 publications with ARHGEF11 and Lung Neoplasms
Genital Diseases, Male Antibodies	>1 publications with ARHGEF11 and Genital Diseases, Male
Prostatic Diseases Antibodies	>1 publications with ARHGEF11 and Prostatic Diseases

Organs/Tissues associated with anti-ARHGEF11 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5 publications with ARHGEF11 and Brain
Kidney Antibodies	>4 publications with ARHGEF11 and Kidney
Nerve Antibodies	>3 publications with ARHGEF11 and Nerve
Blood Antibodies	>3 publications with ARHGEF11 and Blood
Ganglia Antibodies	>1 publications with ARHGEF11 and Ganglia
Uterus Antibodies	>1 publications with ARHGEF11 and Uterus
Prostate Antibodies	>1 publications with ARHGEF11 and Prostate
Embryonic Tissue Antibodies	>1 publications with ARHGEF11 and Embryonic Tissue
Lung Antibodies	>1 publications with ARHGEF11 and Lung
Ear Antibodies	>1 publications with ARHGEF11 and Ear