Rabbit Anti-AKAP7 Polyclonal Antibody – Cat# MBS627497

AKAP7 Antibody – Rabbit Polyclonal

Name: AKAP7 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS627497
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627497

AKAP7 is a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AKAP7, Polyclonal Antibody

Full Product Name

AKAP7, CT (A-kinase Anchor Protein 7 Isoforms alpha and beta, AKAP-7 Isoforms alpha and beta, Protein Kinase A-anchoring Protein 7 Isoforms alpha/beta, A-kinase Anchor Protein 18kD, AKAP 18, AKAP18)

Product Gene Name

anti-AKAP7 antibody

Product Synonym Names

Anti -AKAP7, CT (A-kinase Anchor Protein 7 Isoforms alpha and beta, AKAP-7 Isoforms alpha and beta, Protein Kinase A-anchoring Protein 7 Isoforms alpha/beta, A-kinase Anchor Protein 18kD, AKAP 18, AKAP18)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.09% sodium azide.

Purity/Purification

Purified
Purified by ammonium sulfate precipitation.

Specificity

Recognizes human AKAP7.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

11,465 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (131466461..131604673). Location: 6q23

OMIM

604693

3D Structure

ModBase 3D Structure for O43687

Immunogen

Synthetic peptide selected from the C-terminal region of human AKAP7 (KLH).

Product Categories/Family for anti-AKAP7 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-AKAP7 antibody

ELISA (EL/EIA), Immunohistochemistry (IHC)

Application Notes for anti-AKAP7 antibody

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:10-1:50

Other Notes

Small volumes of anti-AKAP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKAP7 purchase

MBS627497 is an antibody targeting AKAP7. Also known as AKAP7, CT (A-kinase Anchor Protein 7 Isoforms alpha and beta, AKAP-7 Isoforms alpha and beta, Protein Kinase A-anchoring Protein 7 Isoforms alpha/beta, A-kinase Anchor Protein 18kD, AKAP 18, AKAP18). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AKAP7. It may not necessarily be applicable to this product.

NCBI GI #

330864783

NCBI GeneID

9465

NCBI Accession #

NP_057461.2

UniProt Primary Accession #

O43687

UniProt Secondary Accession #

Q5TBR9; Q5TBS0; Q9HCZ8; Q9P0G4; A8K2K6

UniProt Related Accession #

O43687; Q2TAJ5; Q6P4D3; Q9P0M2

GenBank Nucleotide #

NM_016377.3

NCBI Official Full Name

A-kinase anchor protein 7 isoform gamma isoform gamma

NCBI Official Synonym Full Names

A kinase (PRKA) anchor protein 7

NCBI Official Symbol

AKAP7

NCBI Official Synonym Symbols

AKAP15; AKAP18

UniProt Protein Name

A-kinase anchor protein 7 isoforms alpha and beta

UniProt Synonym Protein Names

A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta

Protein Family

A-kinase anchor protein

UniProt Gene Name

AKAP7

UniProt Synonym Gene Names

AKAP18

UniProt Entry Name

AKA7A_HUMAN

NCBI Protein Information

A-kinase anchor protein 7 isoform gamma; AKAP 18; OTTHUMP00000017200; OTTHUMP00000017201; OTTHUMP00000017202; OTTHUMP00000239966; AKAP-7 isoform gamma; A-kinase anchor protein 9 kDa; A-kinase anchor protein 18 kDa; AKAP-7 isoforms alpha and beta; A-kinase anchor protein 7 isoforms alpha and beta

NCBI Summary for AKAP7

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.

UniProt Comments for AKAP7

AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: apical plasma membrane; plasma membrane; cytosol; nucleus; lateral plasma membrane

Molecular Function: protein binding; protein kinase A binding; nucleotide binding; protein kinase binding

Biological Process: regulation of action potential; protein localization; ion transport

Research Articles on AKAP7

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AKAP7 antibody

Products by Pathway	Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram

Diseases associated with anti-AKAP7 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>3 publications with AKAP7 and Heart Diseases
Heart Failure Antibodies	>2 publications with AKAP7 and Heart Failure
Muscle Weakness Antibodies	>1 publications with AKAP7 and Muscle Weakness
Heart Defects, Congenital Antibodies	>1 publications with AKAP7 and Heart Defects, Congenital
Hypertrophy Antibodies	>1 publications with AKAP7 and Hypertrophy
Congenital Abnormalities Antibodies	>1 publications with AKAP7 and Congenital Abnormalities

Organs/Tissues associated with anti-AKAP7 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>14 publications with AKAP7 and Muscle
Kidney Antibodies	>5 publications with AKAP7 and Kidney
Brain Antibodies	>5 publications with AKAP7 and Brain
Pancreas Antibodies	>2 publications with AKAP7 and Pancreas
Blood Antibodies	>1 publications with AKAP7 and Blood
Nerve Antibodies	>1 publications with AKAP7 and Nerve
Vascular Antibodies	>1 publications with AKAP7 and Vascular
Thyroid Antibodies	>1 publications with AKAP7 and Thyroid