Rabbit Anti-ARHGEF18 Polyclonal Antibody – Cat# MBS6274977

ARHGEF18 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ARHGEF18 antibody detected the ARHGEF18 protein (arrow).

ARHGEF18 Antibody – Rabbit Polyclonal

Name: ARHGEF18 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6274977
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6274977

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ARHGEF18, Polyclonal Antibody

Full Product Name

ARHGEF18, NT (ARHGEF18, KIAA0521, Rho guanine nucleotide exchange factor 18, 114kD Rho-specific guanine nucleotide exchange factor, Septin-associated RhoGEF) (Azide free) (HRP)

Product Gene Name

anti-ARHGEF18 antibody

Product Synonym Names

ARHGEF18; KIAA0521; Rho guanine nucleotide exchange factor 18; 114kD Rho-specific guanine nucleotide exchange factor; Septin-associated RhoGEF

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

114,077 Da

3D Structure

ModBase 3D Structure for Q6ZSZ5

Immunogen

ARHGEF18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human ARHGEF18.

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-ARHGEF18 antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

Applications Tested/Suitable for anti-ARHGEF18 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ARHGEF18 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ARHGEF18 antibody

Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010). Niu, J., et al. Circ. Res. 93(9):848-856(2003). Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003): Salehi, A.H., et al. J. Biol. Chem. 277(50):48043-48050(2002). Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002).

Other Notes

Small volumes of anti-ARHGEF18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARHGEF18 purchase

MBS6274977 is an antibody targeting ARHGEF18. Also known as ARHGEF18, NT (ARHGEF18, KIAA0521, Rho guanine nucleotide exchange factor 18, 114kD Rho-specific guanine nucleotide exchange factor, Septin-associated RhoGEF) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF18. It may not necessarily be applicable to this product.

NCBI GI #

41327769

NCBI GeneID

23370

NCBI Accession #

NP_056133.2

NCBI Related Accession #

NP_001124427.1

UniProt Primary Accession #

Q6ZSZ5

UniProt Secondary Accession #

O60274; Q6DD92; A8MV62; B5ME81

UniProt Related Accession #

Q6ZSZ5

GenBank Nucleotide #

NM_015318.3

NCBI Official Full Name

rho guanine nucleotide exchange factor 18 isoform a

NCBI Official Synonym Full Names

Rho/Rac guanine nucleotide exchange factor 18

NCBI Official Symbol

ARHGEF18

NCBI Official Synonym Symbols

P114-RhoGEF

UniProt Protein Name

Rho guanine nucleotide exchange factor 18

UniProt Synonym Protein Names

114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEF; Septin-associated RhoGEF; SA-RhoGEF

Protein Family

Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF18

UniProt Synonym Gene Names

KIAA0521; p114-Rho-GEF; p114RhoGEF; SA-RhoGEF

UniProt Entry Name

ARHGI_HUMAN

NCBI Protein Information

rho guanine nucleotide exchange factor 18

Research Articles on ARHGEF18

1. CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA activation levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARHGEF18 antibody

Products by Pathway	Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
G Alpha (12/13) Signalling Events Pathway antibodies	G Alpha (12/13) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
NRAGE Signals Death Through JNK Pathway antibodies	NRAGE Signals Death Through JNK Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram
Rho GTPase Cycle Pathway antibodies	Rho GTPase Cycle Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram
Signaling By Rho GTPases Pathway antibodies	Signaling By Rho GTPases Pathway Diagram
Signaling By TGF-beta Receptor Complex Pathway antibodies	Signaling By TGF-beta Receptor Complex Pathway Diagram

Diseases associated with anti-ARHGEF18 antibody

Disease Name	Pubmed Publications
Edema Antibodies	>1 publications with ARHGEF18 and Edema
Adenocarcinoma Antibodies	>1 publications with ARHGEF18 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>1 publications with ARHGEF18 and Neoplasm Metastasis

Organs/Tissues associated with anti-ARHGEF18 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with ARHGEF18 and Lung
Eye Antibodies	>2 publications with ARHGEF18 and Eye
Kidney Antibodies	>2 publications with ARHGEF18 and Kidney
Heart Antibodies	>1 publications with ARHGEF18 and Heart
Vascular Antibodies	>1 publications with ARHGEF18 and Vascular
Lymph Node Antibodies	>1 publications with ARHGEF18 and Lymph Node
Lymph Antibodies	>1 publications with ARHGEF18 and Lymph
Blood Antibodies	>1 publications with ARHGEF18 and Blood
Liver Antibodies	>1 publications with ARHGEF18 and Liver