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ARPC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6275343

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this… More details

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Product Overview

Online Datasheet in PDF
Product Name
ARPC2, Polyclonal Antibody
Full Product Name
ARPC2, CT (ARPC2, ARC34, Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34kD subunit) (MaxLight 550)
Product Gene Name
anti-ARPC2 antibody
Product Synonym Names
ARPC2; ARC34; Actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34kD subunit
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
34,333 Da
OMIM
604224
3D Structure
ModBase 3D Structure for O15144
Immunogen
ARPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human ARPC2.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-ARPC2 antibody

Antibodies; Actin Related Proteins
Applications Tested/Suitable for anti-ARPC2 antibody
Western Blot (WB), FLISA
Application Notes for anti-ARPC2 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ARPC2 antibody

Monfregola, J., et al. J. Biol. Chem. 285(22):16951-16957(2010). Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010). Franke, A., et al. Nat. Genet. 40(11):1319-1323(2008). Xiao, F., et al. Brain Res. 1233, 168-175 (2008): Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007).

Other Notes

Small volumes of anti-ARPC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARPC2 purchase

MBS6275343 is an antibody targeting ARPC2. Also known as ARPC2, CT (ARPC2, ARC34, Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34kD subunit) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARPC2. It may not necessarily be applicable to this product.

NCBI GI #
23238211
NCBI GeneID
10109
NCBI Accession #
NP_690601.1
UniProt Primary Accession #
O15144
UniProt Secondary Accession #
Q92801; Q9P1D4
UniProt Related Accession #
O15144
GenBank Nucleotide #
NM_152862.2
NCBI Official Full Name
actin-related protein 2/3 complex subunit 2
NCBI Official Synonym Full Names
actin related protein 2/3 complex, subunit 2, 34kDa
NCBI Official Symbol
ARPC2
NCBI Official Synonym Symbols
ARC34; PRO2446; p34-Arc; PNAS-139
UniProt Protein Name
Actin-related protein 2/3 complex subunit 2
UniProt Synonym Protein Names
Arp2/3 complex 34 kDa subunit; p34-ARC
UniProt Gene Name
ARPC2
UniProt Synonym Gene Names
ARC34; p34-ARC
UniProt Entry Name
ARPC2_HUMAN
NCBI Protein Information
actin-related protein 2/3 complex subunit 2; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34

NCBI Summary for ARPC2

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for ARPC2

ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: Golgi apparatus; Arp2/3 protein complex; neuron projection; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding

Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility
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Research Articles on ARPC2

1. The Arp2/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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