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ARPP-21 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6275355

Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity). More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARPP-21, Polyclonal Antibody
Full Product Name
ARPP-21, NT (ARPP21, TARPP, cAMP-regulated phosphoprotein 21, Thymocyte cAMP-regulated phosphoprotein) (MaxLight 650)
Product Gene Name
Product Synonym Gene Name
ARPP21
Product Synonym Names
ARPP21; TARPP; cAMP-regulated phosphoprotein 21; Thymocyte cAMP-regulated phosphoprotein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
89,196 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (35680666..35835988). Location: 3p22.3
OMIM
605488
3D Structure
ModBase 3D Structure for Q9UBL0
Immunogen
ARPP-21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-114 amino acids from the N-terminal region of human ARPP-21.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-ARPP-21 antibody

Applications Tested/Suitable for anti-ARPP-21 antibody
Western Blot (WB), FLISA
Application Notes for anti-ARPP-21 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ARPP-21 antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). Brill, L.M., et al. Anal. Chem. 76(10):2763-2772(2004). Brill, L.M., et al. Anal. Chem. 76(10):2763-2772(2004).

Other Notes

Small volumes of anti-ARPP-21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARPP-21 purchase

MBS6275355 is an antibody targeting ARPP-21. Also known as ARPP-21, NT (ARPP21, TARPP, cAMP-regulated phosphoprotein 21, Thymocyte cAMP-regulated phosphoprotein) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARPP-21. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cAMP-regulated phosphoprotein 21 isoform 2
NCBI Official Synonym Full Names
cAMP-regulated phosphoprotein, 21kDa
NCBI Official Symbol
ARPP21
NCBI Official Synonym Symbols
RCS; TARPP; R3HDM3; ARPP-21
UniProt Protein Name
cAMP-regulated phosphoprotein 21
UniProt Synonym Protein Names
Thymocyte cAMP-regulated phosphoprotein
UniProt Gene Name
ARPP21
UniProt Synonym Gene Names
TARPP; ARPP-21
UniProt Entry Name
ARP21_HUMAN
NCBI Protein Information
cAMP-regulated phosphoprotein 21; R3H domain containing 3; thymocyte cAMP-regulated phosphoprotein; cyclic AMP-regulated phosphoprotein, 21 kD

NCBI Summary for ARPP-21

This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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UniProt Comments for ARPP-21

ARPP-21: a cytosolic neuronal phosphoprotein highly enriched in the striatum and in other dopamine-innervated regions of the brain. Phosphorylated in a c-AMP dependent fashion.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: cytoplasm

Molecular Function: calmodulin binding; nucleic acid binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-ARPP-21 antibody

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