Rabbit Anti-ATP2C1 Polyclonal Antibody – Cat# MBS6276471

ATP2C1 Antibody (C-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the ATP2C1 antibody detected the ATP2C1 protein (arrow).

ATP2C1 Antibody – Rabbit Polyclonal

Name: ATP2C1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6276471
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6276471

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATP2C1, Polyclonal Antibody

Full Product Name

ATP2C1, CT (ATP2C1, KIAA1347, PMR1L, Calcium-transporting ATPase type 2C member 1, ATP-dependent Ca(2+) pump PMR1) (Biotin)

Product Gene Name

anti-ATP2C1 antibody

Product Synonym Names

ATP2C1; KIAA1347; PMR1L; Calcium-transporting ATPase type 2C member 1; ATP-dependent Ca(2+) pump PMR1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

OMIM

phenotype 604384

3D Structure

ModBase 3D Structure for P98194

Immunogen

ATP2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 881-909 amino acids from the C-terminal region of human ATP2C1.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-ATP2C1 antibody

Antibodies; Ion Channel

Applications Tested/Suitable for anti-ATP2C1 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ATP2C1 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ATP2C1 antibody

Baron, S., et al. Biochim. Biophys. Acta 1798(8):1512-1521(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Tian, H., et al. J. Dermatol. Sci. 58(1):80-82(2010). Ding, Y.G., et al. Clin. Exp. Dermatol. 34 (8), E968-E971 (2009): Nechama, M., et al. BMC Cell Biol. 10, 70 (2009).

Other Notes

Small volumes of anti-ATP2C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATP2C1 purchase

MBS6276471 is an antibody targeting ATP2C1. Also known as ATP2C1, CT (ATP2C1, KIAA1347, PMR1L, Calcium-transporting ATPase type 2C member 1, ATP-dependent Ca(2+) pump PMR1) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATP2C1. It may not necessarily be applicable to this product.

NCBI GI #

48762689

NCBI GeneID

27032

NCBI Accession #

NP_001001486.1

NCBI Related Accession #

NP_001001485.1

UniProt Primary Accession #

P98194

UniProt Related Accession #

P98194

GenBank Nucleotide #

NP_001001486.1

NCBI Official Full Name

calcium-transporting ATPase type 2C member 1 isoform 1d

NCBI Official Synonym Full Names

ATPase secretory pathway Ca2+ transporting 1

NCBI Official Symbol

ATP2C1

NCBI Official Synonym Symbols

HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A

UniProt Protein Name

Calcium-transporting ATPase type 2C member 1

UniProt Synonym Protein Names

ATP-dependent Ca(2+) pump PMR1

Protein Family

Calcium-transporting ATPase

UniProt Gene Name

ATP2C1

UniProt Synonym Gene Names

KIAA1347; PMR1L; ATPase 2C1

UniProt Entry Name

AT2C1_HUMAN

NCBI Protein Information

calcium-transporting ATPase type 2C member 1

NCBI Summary for ATP2C1

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

UniProt Comments for ATP2C1

ATP2C1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; EC 3.6.3.8

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: Golgi membrane; Golgi apparatus; membrane; integral to membrane; trans-Golgi network

Molecular Function: manganese-transporting ATPase activity; signal transducer activity; calcium-transporting ATPase activity; manganese ion binding; metal ion binding; calcium ion binding; ATP binding

Biological Process: cellular calcium ion homeostasis; Golgi calcium ion homeostasis; epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; metabolic process; calcium ion transport; calcium-dependent cell-cell adhesion; actin cytoskeleton reorganization; manganese ion transport; cellular manganese ion homeostasis; signal transduction; Golgi calcium ion transport; transmembrane transport

Disease: Benign Chronic Pemphigus

Research Articles on ATP2C1

1. Our findings update the spectrum of mutations in ATP2C1 in Hailey-Hailey disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATP2C1 antibody

Reference Product	PubMed Publications
ATP2C2 antibody	>8 publications with ATP2C1 and ATP2C2
ATP2B2 antibody	>4 publications with ATP2C1 and ATP2B2
ATP2B1 antibody	>1 publications with ATP2C1 and ATP2B1
SOD2 antibody	>1 publications with ATP2C1 and SOD2

Pathways associated with anti-ATP2C1 antibody

Products by Pathway	Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ion Transport By P-type ATPases Pathway antibodies	Ion Transport By P-type ATPases Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ATP2C1 antibody

Disease Name	Pubmed Publications
Pemphigus, Benign Familial Antibodies	>85 publications with ATP2C1 and Pemphigus, Benign Familial
Death Antibodies	>5 publications with ATP2C1 and Death
Nervous System Diseases Antibodies	>5 publications with ATP2C1 and Nervous System Diseases
Carcinoma Antibodies	>4 publications with ATP2C1 and Carcinoma
Cardiovascular Diseases Antibodies	>2 publications with ATP2C1 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>2 publications with ATP2C1 and Breast Neoplasms
Immune System Diseases Antibodies	>1 publications with ATP2C1 and Immune System Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with ATP2C1 and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>1 publications with ATP2C1 and Liver Diseases
Inflammation Antibodies	>1 publications with ATP2C1 and Inflammation