Rabbit Anti-ATP6V1H Polyclonal Antibody – Cat# MBS6276722

Western blot analysis of ATP6V1H Antibody (C-term) in mouse kidney tissue lysates (35ug/lane).ATP6V1H (arrow) was detected using the purified Pab.

ATP6V1H Antibody – Rabbit Polyclonal

Name: ATP6V1H Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6276722
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6276722

MBS6276722 is an antibody targeting ATP6V1H. Also known as ATP6V1H, CT (ATP6V1H, V-type proton ATPase subunit H, Nef-binding protein 1, Protein VMA13 homolog, V-ATPase 50/57kD subunits, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD) (AP).… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATP6V1H, Polyclonal Antibody

Full Product Name

ATP6V1H, CT (ATP6V1H, V-type proton ATPase subunit H, Nef-binding protein 1, Protein VMA13 homolog, V-ATPase 50/57kD subunits, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD) (AP)

Product Gene Name

anti-ATP6V1H antibody

Product Synonym Names

ATP6V1H; V-type proton ATPase subunit H; Nef-binding protein 1; Protein VMA13 homolog; V-ATPase 50/57kD subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

55,883 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (54628103..54755871, complement). Location: 8q11.2

OMIM

608861

3D Structure

ModBase 3D Structure for Q9UI12

Immunogen

ATP6V1H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-437 amino acids from the C-terminal region of human ATP6V1H.

Conjugate

Note

Preservative Free

Product Categories/Family for anti-ATP6V1H antibody

Antibodies; Binding Proteins

Applications Tested/Suitable for anti-ATP6V1H antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ATP6V1H antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ATP6V1H antibody

Fuster, D.G., et al. Kidney Int. 73(10):1151-1158(2008). Stove, V., et al. J. Virol. 79(17):11422-11433(2005). Morel, N. Biol. Cell 95(7):453-457(2003).

Other Notes

Small volumes of anti-ATP6V1H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ATP6V1H. It may not necessarily be applicable to this product.

NCBI GI #

47717104

NCBI GeneID

51606

NCBI Accession #

NP_057025.2

UniProt Primary Accession #

Q9UI12

UniProt Secondary Accession #

Q6PK44; Q9H3E3; Q9Y300; B3KMR0

UniProt Related Accession #

Q9UI12

GenBank Nucleotide #

NM_015941.3

NCBI Official Full Name

V-type proton ATPase subunit H isoform 1

NCBI Official Synonym Full Names

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

NCBI Official Symbol

ATP6V1H

NCBI Official Synonym Symbols

SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha

UniProt Protein Name

V-type proton ATPase subunit H

UniProt Synonym Protein Names

Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD

Protein Family

V-type proton ATPase

UniProt Gene Name

ATP6V1H

UniProt Synonym Gene Names

V-ATPase subunit H; NBP1

UniProt Entry Name

VATH_HUMAN

NCBI Protein Information

V-type proton ATPase subunit H; V-ATPase subunit H; nef-binding protein 1; protein VMA13 homolog; vacuolar ATPase subunit H; V-ATPase 50/57 kDa subunits; vacuolar proton pump subunit H; vacuolar ATP synthase subunit H; vacuolar proton pump subunit SFD

NCBI Summary for ATP6V1H

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

UniProt Comments for ATP6V1H

ATP6V1H: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; EC 3.6.3.14

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: lysosomal membrane; plasma membrane; vacuolar proton-transporting V-type ATPase, V1 domain; cytosol

Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; enzyme regulator activity

Biological Process: interaction with host; vacuolar acidification; viral reproduction; cellular iron ion homeostasis; regulation of catalytic activity; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; endocytosis; transmembrane transport; regulation of defense response to virus by virus

Research Articles on ATP6V1H

1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATP6V1H antibody

Reference Product	PubMed Publications
ATP6V1E1 antibody	>1 publications with ATP6V1H and ATP6V1E1

Pathways associated with anti-ATP6V1H antibody

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Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies	Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
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HIV Infection Pathway antibodies	HIV Infection Pathway Diagram
Host Interactions Of HIV Factors Pathway antibodies	Host Interactions Of HIV Factors Pathway Diagram
Insulin Receptor Recycling Pathway antibodies	Insulin Receptor Recycling Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway antibodies	Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram

Diseases associated with anti-ATP6V1H antibody

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>1 publications with ATP6V1H and Insulin Resistance

Organs/Tissues associated with anti-ATP6V1H antibody

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>2 publications with ATP6V1H and Pancreas
Muscle Antibodies	>1 publications with ATP6V1H and Muscle
Eye Antibodies	>1 publications with ATP6V1H and Eye
Blood Antibodies	>1 publications with ATP6V1H and Blood
Embryonic Tissue Antibodies	>1 publications with ATP6V1H and Embryonic Tissue