AXL Antibody – Rabbit Polyclonal

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family

Cellular Component: extracellular space; cell surface; membrane; cell; integral to membrane; plasma membrane; intracellular

Molecular Function: transferase activity; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phosphoinositide 3-kinase binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; neuron migration; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; negative regulation of neuron apoptosis; inflammatory response; cell differentiation; secretion by cell; forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; immune system process; vagina development; negative regulation of tumor necrosis factor production; phagocytosis; positive regulation of protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; spermatogenesis; blood vessel remodeling; positive regulation of cytokine and chemokine mediated signaling pathway; phosphorylation; apoptotic cell clearance; negative regulation of apoptosis