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B3GNT6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6277163

MBS6277163 is an antibody targeting B3GNT6. Also known as B3GNT6, ID (B3GNT6, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, Core 3 synthase) (APC). Reactive in Human, Mouse. Host: Rabbit. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
B3GNT6, Polyclonal Antibody
Full Product Name
B3GNT6, ID (B3GNT6, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, Core 3 synthase) (APC)
Product Gene Name
anti-B3GNT6 antibody
Product Synonym Names
B3GNT6; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; Core 3 synthase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
42,748 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (76745385..76753020). Location: 11q13.4
OMIM
615315
3D Structure
ModBase 3D Structure for Q6ZMB0
Immunogen
B3GNT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152~182 amino acids from the Central region of human B3GNT6.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-B3GNT6 antibody

Antibodies; Enzymes; Glycosyltransferase
Applications Tested/Suitable for anti-B3GNT6 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-B3GNT6 antibody
IHC: 1:50-100
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-B3GNT6 antibody

Western blot analysis of B3GNT6 Antibody (Center) in mouse brain tissue lysates (35ug/lane). B3GNT6 (arrow) was detected using the purified Pab.
Rabbit Anti-B3GNT6 Polyclonal Antibody – Cat# MBS6277163

Immunohistochemistry (IHC) of anti-B3GNT6 antibody

B3GNT6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the B3GNT6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-B3GNT6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6277163

Product References and Citations for anti-B3GNT6 antibody

Lee, S.H., et al. J. Biol. Chem. 284(25):17157-17169(2009). Iwai, T., et al. Proc. Natl. Acad. Sci. U.S.A. 102(12):4572-4577(2005). Iwai, T., et al. J. Biol. Chem. 277(15):12802-12809(2002).

Other Notes

Small volumes of anti-B3GNT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for B3GNT6. It may not necessarily be applicable to this product.

NCBI GI #
19263732
NCBI GeneID
192134
NCBI Accession #
AAH25357.1
UniProt Primary Accession #
Q6ZMB0
UniProt Secondary Accession #
Q6ZSC5; Q8TAZ4; Q8TDX1; E9PKS1
UniProt Related Accession #
Q6ZMB0
NCBI Official Full Name
B3GNT6 protein
NCBI Official Synonym Full Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
NCBI Official Symbol
B3GNT6
NCBI Official Synonym Symbols
BGnT-6; B3Gn-T6; beta3Gn-T6; beta-1,3-Gn-T6
UniProt Protein Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
UniProt Synonym Protein Names
Core 3 synthase
Protein Family
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
UniProt Gene Name
B3GNT6
UniProt Synonym Gene Names
BGnT-6; Beta-1,3-Gn-T6; Beta-1,3-N-acetylglucosaminyltransferase 6; Beta3Gn-T6
UniProt Entry Name
B3GN6_HUMAN
NCBI Protein Information
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; core 3 synthase; beta-1,3-N-acetylglucosaminyltransferase protein

UniProt Comments for B3GNT6

B3GNT6: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - O-glycan biosynthesis; EC 2.4.1.-

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity; galactosyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; glycoprotein biosynthetic process; O-glycan processing; O-glycan processing, core 3; post-translational protein modification
Show more

Research Articles on B3GNT6

1. alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-B3GNT6 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram

Diseases associated with anti-B3GNT6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with B3GNT6 and Neoplasms
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