Rabbit Anti-BCL6 Polyclonal Antibody – Cat# MBS6278002

BCL6 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BCL6 antibody detected the BCL6 protein (arrow).

BCL6 Antibody – Rabbit Polyclonal

Name: BCL6 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6278002
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6278002

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BCL6, Polyclonal Antibody

Full Product Name

BCL6, CT (BCL6, BCL5, LAZ3, ZBTB27, ZNF51, B Cell lymphoma 6 protein, B Cell lymphoma 5 protein, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51) (FITC)

Product Gene Name

anti-BCL6 antibody

Product Synonym Names

BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

78 kDa

OMIM

109565

3D Structure

ModBase 3D Structure for P41182

Immunogen

BCL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 675-704 amino acids from the C-terminal region of human BCL6.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-BCL6 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

Applications Tested/Suitable for anti-BCL6 antibody

Western Blot (WB), FLISA

Application Notes for anti-BCL6 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-BCL6 antibody

Chang, C.C., et al. J. Immunol. 185(10):5714-5722(2010). Yang, J., et al. J. Biol. Chem. 285(39):29760-29769(2010). Lai, A.Y., et al. J. Exp. Med. 207(9):1939-1950(2010). Ramachandrareddy, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(26):11930-11935(2010). Gomyo, H., et al. Hematology 15(3):157-161(2010).

Other Notes

Small volumes of anti-BCL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCL6 purchase

MBS6278002 is an antibody targeting BCL6. Also known as BCL6, CT (BCL6, BCL5, LAZ3, ZBTB27, ZNF51, B Cell lymphoma 6 protein, B Cell lymphoma 5 protein, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCL6. It may not necessarily be applicable to this product.

NCBI GI #

197927147

NCBI GeneID

604

NCBI Accession #

NP_001128210.1

NCBI Related Accession #

NP_001124317.1; NP_001697.2

UniProt Primary Accession #

P41182

UniProt Secondary Accession #

A7E241; B8PSA7; D3DNV5

UniProt Related Accession #

P41182

GenBank Nucleotide #

NM_001134738.1

NCBI Official Full Name

B-cell lymphoma 6 protein isoform 2

NCBI Official Synonym Full Names

B-cell CLL/lymphoma 6

NCBI Official Symbol

BCL6

NCBI Official Synonym Symbols

BCL5; LAZ3; BCL6A; ZNF51; ZBTB27

UniProt Protein Name

B-cell lymphoma 6 protein

UniProt Synonym Protein Names

B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

Protein Family

B-cell lymphoma 6 protein

UniProt Gene Name

BCL6

UniProt Synonym Gene Names

BCL5; LAZ3; ZBTB27; ZNF51; BCL-6; BCL-5

UniProt Entry Name

BCL6_HUMAN

NCBI Protein Information

B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys-his2 zinc finger transcription factor; lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; zinc finger and BTB domain-containing

UniProt Comments for BCL6

Bcl-6: a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL.

Protein type: C2H2-type zinc finger protein; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: replication fork; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; chromatin DNA binding; metal ion binding; chromatin binding; transcription factor activity

Biological Process: erythrocyte development; positive regulation of apoptosis; regulation of memory T cell differentiation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Rho protein signal transduction; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; positive regulation of histone deacetylation; positive regulation of B cell proliferation; germinal center formation; negative regulation of mast cell cytokine production; inflammatory response; negative regulation of T-helper 2 cell differentiation; regulation of immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of cell motility; negative regulation of cell-matrix adhesion; regulation of germinal center formation; negative regulation of Rho protein signal transduction; protein import into nucleus, translocation; B cell differentiation; regulation of inflammatory response; negative regulation of Notch signaling pathway; spermatogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; actin cytoskeleton organization and biogenesis; response to DNA damage stimulus; negative regulation of B cell apoptosis

Research Articles on BCL6

1. Data indicate that the rates of BCL6 gene rearrangement, P53 gene deletion and MYC rearrangement were 21.5% (14/65), 35.4% (23/65) and 7.7% (5/65), respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCL6 antibody

Reference Product	PubMed Publications
JUN antibody	>98 publications with BCL6 and JUN
IRF4 antibody	>74 publications with BCL6 and IRF4
BCOR antibody	>49 publications with BCL6 and BCOR
TP53 antibody	>34 publications with BCL6 and TP53
NCOR2 antibody	>11 publications with BCL6 and NCOR2
NCOR1 antibody	>5 publications with BCL6 and NCOR1
HDAC1 antibody	>5 publications with BCL6 and HDAC1
HDAC5 antibody	>4 publications with BCL6 and HDAC5
JUNB antibody	>2 publications with BCL6 and JUNB
HDAC9 antibody	>1 publications with BCL6 and HDAC9

Pathways associated with anti-BCL6 antibody

Products by Pathway	Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
DNA Damage Response (only ATM Dependent) Pathway antibodies	DNA Damage Response (only ATM Dependent) Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
FoxO Family Signaling Pathway antibodies	FoxO Family Signaling Pathway Diagram
FoxO Signaling Pathway antibodies	FoxO Signaling Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Signaling Events Mediated By HDAC Class II Pathway antibodies	Signaling Events Mediated By HDAC Class II Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-BCL6 antibody

Disease Name	Pubmed Publications
Lymphoma, T-Cell Antibodies	>112 publications with BCL6 and Lymphoma, T-Cell
Neoplasms, Experimental Antibodies	>80 publications with BCL6 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>57 publications with BCL6 and Cell Transformation, Neoplastic
Inflammation Antibodies	>50 publications with BCL6 and Inflammation
Carcinoma Antibodies	>30 publications with BCL6 and Carcinoma
Breast Neoplasms Antibodies	>26 publications with BCL6 and Breast Neoplasms
Multiple Myeloma Antibodies	>24 publications with BCL6 and Multiple Myeloma
Hyperplasia Antibodies	>22 publications with BCL6 and Hyperplasia
Disease Models, Animal Antibodies	>21 publications with BCL6 and Disease Models, Animal
Necrosis Antibodies	>16 publications with BCL6 and Necrosis

Organs/Tissues associated with anti-BCL6 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>494 publications with BCL6 and Blood
Lymph Node Antibodies	>290 publications with BCL6 and Lymph Node
Lymph Antibodies	>106 publications with BCL6 and Lymph
Bone Antibodies	>86 publications with BCL6 and Bone
Skin Antibodies	>41 publications with BCL6 and Skin
Spleen Antibodies	>37 publications with BCL6 and Spleen
Brain Antibodies	>27 publications with BCL6 and Brain
Liver Antibodies	>26 publications with BCL6 and Liver
Lung Antibodies	>22 publications with BCL6 and Lung
Stomach Antibodies	>18 publications with BCL6 and Stomach