• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ICMT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627819

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ICMT, Polyclonal Antibody
Full Product Name
ICMT, CT (Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine Carboxylmethyltransferase, Prenylcysteine Carboxyl Methyltransferase, pcCMT, Prenylated Protein Carboxyl Methyltransferase, PPMT, ICMT, PCCMT)
Product Gene Name
anti-ICMT antibody
Product Synonym Names
Anti -ICMT, CT (Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine Carboxylmethyltransferase, Prenylcysteine Carboxyl Methyltransferase, pcCMT, Prenylated Protein Carboxyl Methyltransferase, PPMT, ICMT, PCCMT)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human ICMT.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
31,938 Da
3D Structure
ModBase 3D Structure for Q6FHT0
Immunogen
Synthetic peptide selected from the C-terminal region of human ICMT (KLH).

Product Categories/Family for anti-ICMT antibody

Antibodies; Abs to Enzymes; Methyltransferase
Applications Tested/Suitable for anti-ICMT antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ICMT antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-ICMT antibody

The anti-ICMT Pab is used in Western blot to detect ICMT in T47D (left) and SK-BR-3 (right) tissue lysate
Rabbit Anti-ICMT Polyclonal Antibody – Cat# MBS627819

Other Notes

Small volumes of anti-ICMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICMT purchase

MBS627819 is an antibody targeting ICMT. Also known as ICMT, CT (Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine Carboxylmethyltransferase, Prenylcysteine Carboxyl Methyltransferase, pcCMT, Prenylated Protein Carboxyl Methyltransferase, PPMT, ICMT, PCCMT). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ICMT. It may not necessarily be applicable to this product.

NCBI GI #
49456383
UniProt Primary Accession #
Q6FHT0
NCBI Official Full Name
ICMT
UniProt Protein Name
ICMT protein
Protein Family
Probable protein-S-isoprenylcysteine O-methyltransferase
UniProt Gene Name
ICMT
UniProt Entry Name
Q6FHT0_HUMAN

NCBI Summary for ICMT

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for ICMT

ICMT: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Belongs to the isoprenylcysteine O-methyltransferase family.

Protein type: EC 2.1.1.100; Endoplasmic reticulum; Membrane protein, multi-pass; Transcription, coactivator/corepressor; Methyltransferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein-S-isoprenylcysteine O-methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; cAMP response element binding protein binding

Biological Process: regulation of Ras protein signal transduction; in utero embryonic development; C-terminal protein amino acid methylation; multicellular organism growth; positive regulation of cell proliferation; protein modification process; protein targeting to membrane; liver development
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ICMT antibody

 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with ICMT and FLNA

Pathways associated with anti-ICMT antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with anti-ICMT antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with ICMT and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with ICMT and Cell Transformation, Neoplastic
 Inflammation Antibodies  >3 publications with ICMT and Inflammation
 Neural Tube Defects Antibodies  >1 publications with ICMT and Neural Tube Defects
 Acute Lung Injury Antibodies  >1 publications with ICMT and Acute Lung Injury
 Muscular Diseases Antibodies  >1 publications with ICMT and Muscular Diseases
 Abnormalities, Multiple Antibodies  >1 publications with ICMT and Abnormalities, Multiple
 Fetal Diseases Antibodies  >1 publications with ICMT and Fetal Diseases
 Translocation, Genetic Antibodies  >1 publications with ICMT and Translocation, Genetic
 Skin Neoplasms Antibodies  >1 publications with ICMT and Skin Neoplasms

Organs/Tissues associated with anti-ICMT antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with ICMT and Lung
 Brain Antibodies  >4 publications with ICMT and Brain
 Muscle Antibodies  >3 publications with ICMT and Muscle
 Heart Antibodies  >2 publications with ICMT and Heart
 Connective Tissue Antibodies  >1 publications with ICMT and Connective Tissue
 Prostate Antibodies  >1 publications with ICMT and Prostate
 Pancreas Antibodies  >1 publications with ICMT and Pancreas
 Kidney Antibodies  >1 publications with ICMT and Kidney
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000