ATP5B Antibody – Rabbit Polyclonal

ATP5B: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase alpha/beta chains family.

Protein type: Mitochondrial; Hydrolase; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation

Cellular Component: cell surface; membrane; mitochondrion; proton-transporting ATP synthase complex, catalytic core F(1); mitochondrial inner membrane; mitochondrial membrane; plasma membrane; nucleus; myelin sheath; mitochondrial proton-transporting ATP synthase complex

Molecular Function: lipoprotein receptor activity; hydrolase activity; MHC class I protein binding; ATPase activity; nucleotide binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; calcium ion binding; hydrogen ion transporting ATPase activity, rotational mechanism; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; ATP binding

Biological Process: receptor-mediated endocytosis; substrate-bound cell migration, cell release from substrate; ATP synthesis coupled proton transport; ADP biosynthetic process; ATP metabolic process; osteoblast differentiation; proton transport; transport; ATP biosynthetic process; ATP hydrolysis coupled proton transport; regulation of intracellular pH; ion transport; angiogenesis; lipid metabolic process