• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Calcipressin 1 (RCAN1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627900

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Calcipressin 1 (RCAN1), Polyclonal Antibody
Full Product Name
Calcipressin 1, CT (DSCR1, Regulator Of Calcineurin 1, DSCR1, Down Syndrome Critical Region Protein 1, Myocyte-enriched Calcineurin-interacting Protein 1, MCIP1, Adapt78, RCAN1, DSC1, CSP1)
Product Gene Name
Product Synonym Names
Anti -Calcipressin 1, CT (DSCR1, Regulator Of Calcineurin 1, DSCR1, Down Syndrome Critical Region Protein 1, Myocyte-enriched Calcineurin-interacting Protein 1, MCIP1, Adapt78, RCAN1, DSC1, CSP1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human DSCR1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
28,079 Da
Chromosome Location
Chromosome: 21; NC_000021.8 (35888782..35987382, complement). Location: 21q22.1-q22.2; 21q22.12
OMIM
602917
3D Structure
ModBase 3D Structure for P53805
Immunogen
Synthetic peptide selected from the C-terminal region of human DSCR1 (KLH).
Applications Tested/Suitable for anti-RCAN1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-RCAN1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Testing Data of anti-RCAN1 antibody

Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4deg C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor.
Rabbit Anti-RCAN1 Polyclonal Antibody – Cat# MBS627900

Western Blot (WB) of anti-RCAN1 antibody

The anti-DSCR1 Pab is used in Western blot to detect DSCR1 in endothelial tissue lysate.
Rabbit Anti-RCAN1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS627900

Other Notes

Small volumes of anti-RCAN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RCAN1 purchase

MBS627900 is an antibody targeting RCAN1. Also known as Calcipressin 1, CT (DSCR1, Regulator Of Calcineurin 1, DSCR1, Down Syndrome Critical Region Protein 1, Myocyte-enriched Calcineurin-interacting Protein 1, MCIP1, Adapt78, RCAN1, DSC1, CSP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RCAN1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calcipressin-1 isoform a
NCBI Official Synonym Full Names
regulator of calcineurin 1
NCBI Official Symbol
RCAN1
NCBI Official Synonym Symbols
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
UniProt Protein Name
Calcipressin-1
UniProt Synonym Protein Names
Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
Protein Family
UniProt Gene Name
RCAN1
UniProt Synonym Gene Names
ADAPT78; CSP1; DSC1; DSCR1
UniProt Entry Name
RCAN1_HUMAN
NCBI Protein Information
calcipressin-1; OTTHUMP00000108619; OTTHUMP00000108620; OTTHUMP00000108621; OTTHUMP00000108622; OTTHUMP00000214669; OTTHUMP00000214670; near DSCR proline-rich protein; Down syndrome candidate region 1; calcium and oxidant-inducible mRNA; Down syndrome critical region gene 1; down syndrome critical region protein 1; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1

NCBI Summary for RCAN1

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq]
Show more

UniProt Comments for RCAN1

RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; transcription factor activity

Biological Process: central nervous system development; regulation of transcription, DNA-dependent; blood circulation; calcium-mediated signaling; signal transduction
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RCAN1 antibody

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000