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TLK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628091

The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM] More details

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Product Overview

Online Datasheet in PDF
Product Name
TLK1, Polyclonal Antibody
Full Product Name
TLK1, CT (Serine/Threonine-protein Kinase Tousled-like 1, Tousled-like Kinase 1, PKU-beta)
Product Gene Name
anti-TLK1 antibody
Product Synonym Names
Anti -TLK1, CT (Serine/Threonine-protein Kinase Tousled-like 1, Tousled-like Kinase 1, PKU-beta)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human TLK1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
14,617 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (171847333..172017410, complement). Location: 2q31.1
3D Structure
ModBase 3D Structure for Q15444
Immunogen
Synthetic peptide selected from the C-terminal region of human TLK1 (KLH).

Product Categories/Family for anti-TLK1 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-TLK1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TLK1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-TLK1 antibody

Western blot analysis of hTLK1-L687 in K562 cell line lysates (35ug/lane). TLK1 (arrow) was detected using the purified Pab.
Rabbit Anti-TLK1 Polyclonal Antibody – Cat# MBS628091

Immunohistochemistry (IHC) of anti-TLK1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-TLK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628091

Other Notes

Small volumes of anti-TLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLK1 purchase

MBS628091 is an antibody targeting TLK1. Also known as TLK1, CT (Serine/Threonine-protein Kinase Tousled-like 1, Tousled-like Kinase 1, PKU-beta). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLK1. It may not necessarily be applicable to this product.

NCBI GI #
119631628
NCBI GeneID
9874
UniProt Primary Accession #
Q15444
UniProt Related Accession #
Q15444; Q53TE4; Q53TF9; Q9UKI8
NCBI Official Full Name
tousled-like kinase 1, isoform CRA_d
NCBI Official Synonym Full Names
tousled-like kinase 1
NCBI Official Symbol
TLK1
NCBI Official Synonym Symbols
KIAA0137; PKU-beta
UniProt Protein Name
Protein-serine/threonine kinase
Protein Family
Serine/threonine-protein kinase tousled
UniProt Entry Name
Q15444_HUMAN
NCBI Protein Information
serine/threonine-protein kinase tousled-like 1; OTTHUMP00000163076; OTTHUMP00000163077; OTTHUMP00000205037; OTTHUMP00000225037; SNARE protein kinase SNAK; serine threonine protein kinase

NCBI Summary for TLK1

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]

UniProt Comments for TLK1

TLK1: a protein kinase of the TLK family. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation, possibly by CHK1. Three splice variant isoforms have been described.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: intracellular protein transport; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus
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Research Articles on TLK1

1. Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TLK1 antibody

 Reference Product  PubMed Publications
 TLK2 antibody  >4 publications with TLK1 and TLK2

Diseases associated with anti-TLK1 antibody

 Disease Name  Pubmed Publications
 Neoplasm Recurrence, Local Antibodies  >2 publications with TLK1 and Neoplasm Recurrence, Local
 Radiation Injuries Antibodies  >1 publications with TLK1 and Radiation Injuries
 Fibrosis Antibodies  >1 publications with TLK1 and Fibrosis
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