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CABP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628102

CABP1 belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this protein was only detected in retina and… More details

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Product Overview

Online Datasheet in PDF
Product Name
CABP1, Polyclonal Antibody
Full Product Name
CABP1, CT (Calcium-binding Protein 1, CaBP1, Caldendrin, Calbrain)
Product Gene Name
anti-CABP1 antibody
Product Synonym Names
Anti -CABP1, CT (Calcium-binding Protein 1, CaBP1, Caldendrin, Calbrain)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CABP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,838 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (121078422..121105127). Location: 12q24.31
OMIM
605563
3D Structure
ModBase 3D Structure for Q9NZU7
Immunogen
Synthetic peptide selected from the C-terminal region of human CABP1 (KLH).

Product Categories/Family for anti-CABP1 antibody

Antibodies; Abs to Calcium Binding Proteins
Applications Tested/Suitable for anti-CABP1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CABP1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-CABP1 antibody

Western blot analysis of anti-CABP1 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).CABP1(arrow) was detected using the purified Pab.
Rabbit Anti-CABP1 Polyclonal Antibody – Cat# MBS628102

Immunohistochemistry (IHC) of anti-CABP1 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with CABP1 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CABP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628102

Western Blot (WB) of anti-CABP1 antibody

CABP1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CABP1 antibody detected the CABP1 protein (arrow).
Rabbit Anti-CABP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS628102

Other Notes

Small volumes of anti-CABP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CABP1 purchase

MBS628102 is an antibody targeting CABP1. Also known as CABP1, CT (Calcium-binding Protein 1, CaBP1, Caldendrin, Calbrain). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CABP1. It may not necessarily be applicable to this product.

NCBI GI #
76056882
NCBI GeneID
9478
NCBI Accession #
NP_001028849.1
UniProt Primary Accession #
Q9NZU7
UniProt Secondary Accession #
O95663; Q8N6H5; Q9NZU8
UniProt Related Accession #
Q9NZU7
GenBank Nucleotide #
NM_001033677.1
NCBI Official Full Name
calcium-binding protein 1 isoform 3
NCBI Official Synonym Full Names
calcium binding protein 1
NCBI Official Symbol
CABP1
NCBI Official Synonym Symbols
CALBRAIN; HCALB_BR
UniProt Protein Name
Calcium-binding protein 1
UniProt Synonym Protein Names
Calbrain; Caldendrin
Protein Family
Calcium-binding protein
UniProt Gene Name
CABP1
UniProt Entry Name
CABP1_HUMAN
NCBI Protein Information
calcium-binding protein 1; caldendrin; OTTHUMP00000210617; OTTHUMP00000210618; OTTHUMP00000210619; OTTHUMP00000210620; calcium binding protein 5

NCBI Summary for CABP1

The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene was only detected in retina and brain. Study of the mouse homolog demonstrated that groups of cells expressing this protein are located in the center or inner border of the inner unclear layer of retina. Three alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq]
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UniProt Comments for CABP1

CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Calcium-binding; Inhibitor

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space; internal side of plasma membrane; protein complex; dendrite; postsynaptic density; cell cortex; cytosol; Golgi membrane; postsynaptic membrane; cytoskeleton; cell soma; perinuclear region of cytoplasm; plasma membrane; cell junction; nucleus

Molecular Function: enzyme inhibitor activity; protein domain specific binding; protein binding; protein homodimerization activity; nuclear localization sequence binding; type 3 metabotropic glutamate receptor binding; calcium ion binding; calcium-dependent protein binding

Biological Process: negative regulation of catalytic activity; negative regulation of protein import into nucleus
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Research Articles on CABP1

1. CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CABP1 antibody

 Reference Product  PubMed Publications
 ITPR1 antibody  >3 publications with CABP1 and ITPR1

Diseases associated with anti-CABP1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with CABP1 and Liver Diseases
 Lymphoma Antibodies  >1 publications with CABP1 and Lymphoma
 Poisoning Antibodies  >1 publications with CABP1 and Poisoning
 Inflammation Antibodies  >1 publications with CABP1 and Inflammation

Organs/Tissues associated with anti-CABP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with CABP1 and Brain
 Eye Antibodies  >8 publications with CABP1 and Eye
 Kidney Antibodies  >2 publications with CABP1 and Kidney
 Pineal Gland Antibodies  >1 publications with CABP1 and Pineal Gland
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