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Fucosyltransferase 1 (FUT1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628163

FUT1 is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. More details

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Product Overview

Online Datasheet in PDF
Product Name
Fucosyltransferase 1 (FUT1), Polyclonal Antibody
Full Product Name
Fucosyltransferase 1 (FUT1, 2-alpha-L-fucosyltransferase 1, Alpha(1,2)FT 1, Blood Group H alpha 2-fucosyltransferase, Galactoside 2-alpha-L-fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside, H, HH, HSC)
Product Gene Name
anti-FUT1 antibody
Product Synonym Names
Anti -Fucosyltransferase 1 (FUT1, 2-alpha-L-fucosyltransferase 1, Alpha(1,2)FT 1, Blood Group H alpha 2-fucosyltransferase, Galactoside 2-alpha-L-fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside, H, HH, HSC)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human FUT1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,293 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (49251268..49258647, complement). Location: 19q13.3
3D Structure
ModBase 3D Structure for Q8IVN2
Immunogen
Synthetic peptide selected from the Center region of human FUT1 (KLH).

Product Categories/Family for anti-FUT1 antibody

Antibodies; Abs to Enzymes; Glycosyltransferase
Applications Tested/Suitable for anti-FUT1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-FUT1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-FUT1 antibody

Western blot analysis of FUT1 antibody (Center) in CEM cell line lysates (35ug/lane). FUT1 (arrow) was detected using the purified Pab.
Rabbit Anti-FUT1 Polyclonal Antibody – Cat# MBS628163

Flow Cytometry (FC/FACS) of anti-FUT1 antibody

FUT1 Antibody (Center) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FUT1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628163

Other Notes

Small volumes of anti-FUT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FUT1 purchase

MBS628163 is an antibody targeting FUT1. Also known as Fucosyltransferase 1 (FUT1, 2-alpha-L-fucosyltransferase 1, Alpha(1,2)FT 1, Blood Group H alpha 2-fucosyltransferase, Galactoside 2-alpha-L-fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside, H, HH, HSC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FUT1. It may not necessarily be applicable to this product.

NCBI GI #
27526489
NCBI GeneID
2523
NCBI Accession #
CAC81751.1
UniProt Primary Accession #
Q8IVN2
UniProt Related Accession #
P19526
NCBI Official Full Name
fucosyltransferase 1
NCBI Official Synonym Full Names
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
NCBI Official Symbol
FUT1
NCBI Official Synonym Symbols
H; HH; HSC
UniProt Protein Name
Fucosyltransferase 1
Protein Family
Galactoside 2-alpha-L-fucosyltransferase
UniProt Gene Name
FUT1
UniProt Entry Name
Q8IVN2_HUMAN
NCBI Protein Information
galactoside 2-alpha-L-fucosyltransferase 1; alpha(1,2)FT 1; alpha (1,2) fucosyltransferase; blood group H alpha 2-fucosyltransferase; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)

NCBI Summary for FUT1

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008]
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UniProt Comments for FUT1

FUT1: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values. Belongs to the glycosyltransferase 11 family.

Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; EC 2.4.1.69; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: Golgi apparatus; membrane; integral to plasma membrane

Molecular Function: galactoside 2-alpha-L-fucosyltransferase activity; fucosyltransferase activity

Biological Process: carbohydrate metabolic process; protein amino acid glycosylation; L-fucose catabolic process
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Research Articles on FUT1

1. anti-H could accommodate grafts through triggering apoptosis and down-regulating Fut1 expression to reduce ABH antigens

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FUT1 antibody

 Products by Pathway  Pathway Diagram
 Ganglio Sphingolipid Metabolism Pathway antibodies  Ganglio Sphingolipid Metabolism Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram

Organs/Tissues associated with anti-FUT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >14 publications with FUT1 and Intestine
 Uterus Antibodies  >9 publications with FUT1 and Uterus
 Lung Antibodies  >7 publications with FUT1 and Lung
 Bone Antibodies  >7 publications with FUT1 and Bone
 Stomach Antibodies  >6 publications with FUT1 and Stomach
 Brain Antibodies  >6 publications with FUT1 and Brain
 Embryonic Tissue Antibodies  >4 publications with FUT1 and Embryonic Tissue
 Liver Antibodies  >3 publications with FUT1 and Liver
 Testis Antibodies  >2 publications with FUT1 and Testis
 Spleen Antibodies  >2 publications with FUT1 and Spleen
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