Inhibitor of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein (ID2) Antibody – Goat Polyclonal

The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. [provided by RefSeq]

ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: microtubule cytoskeleton; nucleoplasm; centrosome; protein complex; cytoplasm; chromatin; nucleus; cytosol

Molecular Function: protein dimerization activity; protein binding

Biological Process: regulation of lipid metabolic process; positive regulation of smooth muscle cell proliferation; multicellular organismal development; positive regulation of transcription, DNA-dependent; cell maturation; negative regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock by photoperiod; locomotor rhythm; natural killer cell differentiation; embryonic digestive tract morphogenesis; negative regulation of osteoblast differentiation; circadian regulation of gene expression; positive regulation of macrophage differentiation; oligodendrocyte development; positive regulation of astrocyte differentiation; Peyer's patch development; negative regulation of B cell differentiation; transcription, DNA-dependent; negative regulation of transcription factor activity; olfactory bulb development; positive regulation of erythrocyte differentiation; neuron fate commitment; mammary gland epithelial cell proliferation; enucleate erythrocyte differentiation; regulation of circadian rhythm; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure