Receptor A, Alpha 1 (GABA) Antibody – Rabbit Polyclonal

GABA (g-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABA-A, GABA-C and GABA-B receptors (GABAbetaRs). A family of GABA-A receptors subtypes exists. These receptors are generated by alternative splicing of alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pie, theta and rho1-3 to form a heteromeric (pentameric) protein complexes. Various GABA-A subunits show distinct patterns of temporal and spatial expression that may imply its tissue specific physiological role (1). GABA A (GAA) receptor proteins (450-627aa) are characterized by the presence of a cleavable signal peptide, a large extracellular N-terminus, 3 TM (transmembrane) domains, a large cytoplasmic domain followed by TM4 and C-terminal extracellular domain. The regions between TM3-4 and the large cytoplasmic loop are least conserved among various GAA subunits. This variability may confer subunit specific functionality. GAA genes are distributed as clusters throughout the human genome (chromosomes 4, 5, 15 and X; delta subunit on chromosome 1). Human GAA1 (chromosome 5q34-q35) protein is 456aa (rat/mouse: 455aa). Defects in GABRA1 are a cause of Juvenile Myoclonic Epilepsy (JME), a common epileptic syndrome characterized by febrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks. GAA in the brain are the targets of many clinically important drugs.

Small volumes of anti-GABA Receptor A, alpha 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS628243 is an antibody targeting GABA Receptor A, alpha 1. Also known as Anti-GABA Receptor A, alpha 1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit, GAA1). Reactive in Bovine; Chicken; Human; Mouse; Rat. Host: Rabbit.