• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PP1C Gamma (PPP1R15A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628251

Protein phosphatase-1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases involved in the dephosphorylation of a variety of proteins. These enzymes work in opposition to the protein kinases to control the level of phosphorylation. Protein… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PP1C gamma (Ppp1r15a), Polyclonal Antibody
Full Product Name
PP1C gamma, NT (Serine/Threonine Protein Phosphatase PP1-gamma Catalytic Subunit, PP-1G, Protein Phosphatase 1C Catalytic Subunit, PPP1CC)
Product Gene Name
anti-Ppp1r15a antibody
Product Synonym Names
Anti -PP1C gamma, NT (Serine/Threonine Protein Phosphatase PP1-gamma Catalytic Subunit, PP-1G, Protein Phosphatase 1C Catalytic Subunit, PPP1CC)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PPP1CC. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
71,840 Da
Chromosome Location
Chromosome: 7; NC_000073.6 (45522917..45526268, complement). Location: 7 B4; 7
3D Structure
ModBase 3D Structure for P17564
Immunogen
Synthetic peptide selected from the N-terminal region of human PPP1CC (KLH).

Product Categories/Family for anti-Ppp1r15a antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-Ppp1r15a antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Ppp1r15a antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-Ppp1r15a antibody

The anti-PPP1CC Pab is used in Western blot to detect PPP1CC in mouse colon tissue lysate.
Rabbit Anti-PPP1R15A Polyclonal Antibody – Cat# MBS628251

Other Notes

Small volumes of anti-Ppp1r15a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ppp1r15a purchase

MBS628251 is an antibody targeting Ppp1r15a. Also known as PP1C gamma, NT (Serine/Threonine Protein Phosphatase PP1-gamma Catalytic Subunit, PP-1G, Protein Phosphatase 1C Catalytic Subunit, PPP1CC). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Ppp1r15a. It may not necessarily be applicable to this product.

NCBI GI #
6678978
NCBI GeneID
17872
NCBI Accession #
NP_032680.1
UniProt Primary Accession #
P17564
UniProt Secondary Accession #
Q3TJS6; Q3U3L5; Q8C579
UniProt Related Accession #
P17564
GenBank Nucleotide #
NM_008654.2
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 15A
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory (inhibitor) subunit 15A
NCBI Official Symbol
Ppp1r15a
NCBI Official Synonym Symbols
Gadd34; Myd116; 9630030H21
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 15A
UniProt Synonym Protein Names
Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116
Protein Family
Protein phosphatase 1 regulatory
UniProt Gene Name
Ppp1r15a
UniProt Synonym Gene Names
Gadd34; Myd116
UniProt Entry Name
PR15A_MOUSE
NCBI Protein Information
protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; growth arrest and DNA damage-inducible protein GADD34; myeloid differentiation primary response protein MyD116

UniProt Comments for Ppp1r15a

GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Belongs to the PPP1R15 family.

Protein type: Apoptosis; Cell cycle regulation; DNA repair, damage; Translation initiation

Cellular Component: Golgi apparatus; mitochondrial outer membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; protein phosphatase type 1 complex

Molecular Function: protein phosphatase regulator activity; protein kinase binding; protein phosphatase binding; protein phosphatase 1 binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; regulation of translation; negative regulation of protein amino acid dephosphorylation; unfolded protein response; apoptosis; negative regulation of phosphoprotein phosphatase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase I promoter
Show more

Research Articles on Ppp1r15a

1. Data indicate that ATF4/GADD34 and p90ATF6 expression gradually changed, and the levels of cleaved caspase-3 were significantly increased with repetitive cycles of testicular hyperthermia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Ppp1r15a antibody

 Reference Product  PubMed Publications
 Atf4 antibody  >18 publications with Ppp1r15a and Atf4
 Cdkn1a antibody  >8 publications with Ppp1r15a and Cdkn1a
 Kif3a antibody  >1 publications with Ppp1r15a and Kif3a
 Smad7 antibody  >1 publications with Ppp1r15a and Smad7

Pathways associated with anti-Ppp1r15a antibody

 Products by Pathway  Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
 TGF-beta Receptor Signaling Activates SMADs Pathway antibodies  TGF-beta Receptor Signaling Activates SMADs Pathway Diagram

Diseases associated with anti-Ppp1r15a antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with Ppp1r15a and Neoplasms
 Necrosis Antibodies  >14 publications with Ppp1r15a and Necrosis
 Disease Models, Animal Antibodies  >13 publications with Ppp1r15a and Disease Models, Animal
 Nervous System Diseases Antibodies  >12 publications with Ppp1r15a and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >8 publications with Ppp1r15a and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >6 publications with Ppp1r15a and Neoplasms, Experimental
 Liver Diseases Antibodies  >5 publications with Ppp1r15a and Liver Diseases
 Inflammation Antibodies  >4 publications with Ppp1r15a and Inflammation
 Lung Neoplasms Antibodies  >3 publications with Ppp1r15a and Lung Neoplasms
 Fatty Liver Antibodies  >3 publications with Ppp1r15a and Fatty Liver

Organs/Tissues associated with anti-Ppp1r15a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with Ppp1r15a and Blood
 Brain Antibodies  >12 publications with Ppp1r15a and Brain
 Liver Antibodies  >12 publications with Ppp1r15a and Liver
 Lung Antibodies  >5 publications with Ppp1r15a and Lung
 Skin Antibodies  >4 publications with Ppp1r15a and Skin
 Embryonic Tissue Antibodies  >3 publications with Ppp1r15a and Embryonic Tissue
 Lymph Node Antibodies  >2 publications with Ppp1r15a and Lymph Node
 Intestine Antibodies  >2 publications with Ppp1r15a and Intestine
 Testis Antibodies  >2 publications with Ppp1r15a and Testis
 Thyroid Antibodies  >1 publications with Ppp1r15a and Thyroid
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000