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Kynurenine 3-Monooxygenase (KMO) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628299

Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine. More details

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Product Overview

Online Datasheet in PDF
Product Name
Kynurenine 3-monooxygenase (KMO), Polyclonal Antibody
Full Product Name
Kynurenine 3-monooxygenase (KMO, dJ317G22.1, Kynurenine 3-hydroxylase)
Product Gene Name
anti-KMO antibody
Product Synonym Names
Anti -Kynurenine 3-monooxygenase (KMO, dJ317G22.1, Kynurenine 3-hydroxylase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human KMO.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,810 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (241695680..241758944). Location: 1q42-q44
OMIM
603538
3D Structure
ModBase 3D Structure for O15229
Immunogen
Synthetic peptide selected from the Center region of human KMO (KLH).

Product Categories/Family for anti-KMO antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-KMO antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KMO antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-KMO antibody

Western blot analysis of KMO Antibody (Center) in CEM cell line lysates (35ug/lane). KMO (arrow) was detected using the purified Pab.
Rabbit Anti-KMO Polyclonal Antibody – Cat# MBS628299

Immunohistochemistry (IHC) of anti-KMO antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with KMO Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-KMO Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628299

Flow Cytometry (FC/FACS) of anti-KMO antibody

KMO Antibody (Center) flow cytometry analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-KMO Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628299

Other Notes

Small volumes of anti-KMO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KMO purchase

MBS628299 is an antibody targeting KMO. Also known as Kynurenine 3-monooxygenase (KMO, dJ317G22.1, Kynurenine 3-hydroxylase). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KMO. It may not necessarily be applicable to this product.

NCBI GI #
187960045
NCBI GeneID
8564
NCBI Accession #
NP_003670.2
UniProt Primary Accession #
O15229
UniProt Secondary Accession #
Q5SY07; Q5SY08; Q5SY09; A2A2U8; A2A2U9; A2A2V0
UniProt Related Accession #
O15229; Q9BS61
GenBank Nucleotide #
NM_003679.3
NCBI Official Full Name
kynurenine 3-monooxygenase
NCBI Official Synonym Full Names
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
NCBI Official Symbol
KMO
NCBI Official Synonym Symbols
dJ317G22.1
UniProt Protein Name
Kynurenine 3-monooxygenase
UniProt Synonym Protein Names
Kynurenine 3-hydroxylase
Protein Family
Kynurenine 3-monooxygenase
UniProt Gene Name
KMO
UniProt Entry Name
KMO_HUMAN
NCBI Protein Information
kynurenine 3-monooxygenase; OTTHUMP00000037618; OTTHUMP00000037619; OTTHUMP00000037620; kynurenine 3-hydroxylase

UniProt Comments for KMO

KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Amino Acid Metabolism - tryptophan; Membrane protein, multi-pass; Membrane protein, integral; Oxidoreductase; EC 1.14.13.9

Chromosomal Location of Human Ortholog: 1q42-q44

Cellular Component: mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane; cytosol

Molecular Function: FAD binding; NAD(P)H oxidase activity; kynurenine 3-monooxygenase activity

Biological Process: anthranilate metabolic process; tryptophan catabolic process to kynurenine; NAD metabolic process; quinolinate biosynthetic process; tryptophan catabolic process; response to salt stress
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Research Articles on KMO

1. The present analysis of the combined Scandinavian sample did not reveal any allele frequency difference between patients and healthy controls

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KMO antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Superpathway Of NAD Biosynthesis In Eukaryotes antibodies  Superpathway Of NAD Biosynthesis In Eukaryotes Diagram
 Tryptophan Degradation III (eukaryotic) Pathway antibodies  Tryptophan Degradation III (eukaryotic) Pathway Diagram

Diseases associated with anti-KMO antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >12 publications with KMO and Neoplasms
 Central Nervous System Diseases Antibodies  >8 publications with KMO and Central Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >4 publications with KMO and Neurodegenerative Diseases
 Inflammation Antibodies  >3 publications with KMO and Inflammation
 Liver Diseases Antibodies  >3 publications with KMO and Liver Diseases
 Carcinoma Antibodies  >3 publications with KMO and Carcinoma
 Anemia Antibodies  >3 publications with KMO and Anemia
 Stomach Neoplasms Antibodies  >2 publications with KMO and Stomach Neoplasms
 Drug Toxicity Antibodies  >2 publications with KMO and Drug Toxicity
 Adenoma Antibodies  >2 publications with KMO and Adenoma
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