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4e Binding Protein 1 (EIF4EBP1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628382

4E-BP1 (also known as PHAS-1) normally binds eIF4E, inhibiting cap-dependent translation. Hyperphosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation (1). The PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 (2,3).… More details

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Product Overview

Online Datasheet in PDF
Product Name
4E Binding Protein 1 (EIF4EBP1), Polyclonal Antibody
Full Product Name
4E Binding Protein 1, phosphorylated (Thr37/46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP)
Product Gene Name
anti-EIF4EBP1 antibody
Product Synonym Names
Anti -4E Binding Protein 1, phosphorylated (Thr37/46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, BSA, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by protein A and peptide affinity chromatography.
Specificity
Detects endogenous levels of 4E-BP1 only when phosphorylated at Thr37 and/or Thr46. This antibody may crossreact with 4E-BP2 and 4E-BP3 when phosphorylated at equivalent sites.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
12,580 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (37888020..37917883). Location: 8p12
OMIM
602223
3D Structure
ModBase 3D Structure for Q13541
Immunogen
Synthetic phosphopeptide (KLH coupled) corresponding to residues surrounding Thr37 of mouse 4E-BP1 and Thr46 of mouse 4E-BP1.

Product Categories/Family for anti-EIF4EBP1 antibody

Antibodies; Abs to Translation Initiation Factors
Applications Tested/Suitable for anti-EIF4EBP1 antibody
Western Blot (WB)
Application Notes for anti-EIF4EBP1 antibody
Suitable for use in Western Blotting.
Dilution: Western Blot: 1:1000

Other Notes

Small volumes of anti-EIF4EBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIF4EBP1 purchase

MBS628382 is an antibody targeting EIF4EBP1. Also known as 4E Binding Protein 1, phosphorylated (Thr37/46) (Protein Synthesis Initiation Factor 4E Binding Protein, eIF-4EBP1, PHAS-1, PHAS-I, Eukaryotic Translation Initiation Factor BP). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF4EBP1. It may not necessarily be applicable to this product.

NCBI GI #
561630
NCBI GeneID
1978
UniProt Primary Accession #
Q13541
UniProt Secondary Accession #
Q6IBN3; B2R502; D3DSW8
UniProt Related Accession #
Q13541
NCBI Official Full Name
4E-binding protein 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4E binding protein 1
NCBI Official Symbol
EIF4EBP1
NCBI Official Synonym Symbols
BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316
UniProt Protein Name
Eukaryotic translation initiation factor 4E-binding protein 1
UniProt Synonym Protein Names
Phosphorylated heat- and acid-stable protein regulated by insulin 1
Protein Family
Eukaryotic translation initiation factor 4E-binding protein
UniProt Gene Name
EIF4EBP1
UniProt Entry Name
4EBP1_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 4E-binding protein 1; OTTHUMP00000225572; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1

NCBI Summary for EIF4EBP1

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq]
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UniProt Comments for EIF4EBP1

4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol

Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding

Biological Process: negative regulation of translational initiation; response to ethanol; cellular protein metabolic process; TOR signaling pathway; translation; insulin receptor signaling pathway; translational initiation; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; G1/S transition of mitotic cell cycle; lung development
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Research Articles on EIF4EBP1

1. potential prognostic factor for survival in patients with lung adenocarcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EIF4EBP1 antibody

 Reference Product  PubMed Publications
 EIF4E antibody  >407 publications with EIF4EBP1 and EIF4E
 MTOR antibody  >360 publications with EIF4EBP1 and MTOR
 AKT1 antibody  >40 publications with EIF4EBP1 and AKT1
 MAPK1 antibody  >22 publications with EIF4EBP1 and MAPK1
 ATM antibody  >11 publications with EIF4EBP1 and ATM
 RPS6KB1 antibody  >2 publications with EIF4EBP1 and RPS6KB1

Pathways associated with anti-EIF4EBP1 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram

Diseases associated with anti-EIF4EBP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >179 publications with EIF4EBP1 and Neoplasms
 Carcinoma Antibodies  >43 publications with EIF4EBP1 and Carcinoma
 Tuberous Sclerosis Antibodies  >38 publications with EIF4EBP1 and Tuberous Sclerosis
 Hypertrophy Antibodies  >34 publications with EIF4EBP1 and Hypertrophy
 Immune System Diseases Antibodies  >29 publications with EIF4EBP1 and Immune System Diseases
 Breast Neoplasms Antibodies  >27 publications with EIF4EBP1 and Breast Neoplasms
 Leukemia Antibodies  >25 publications with EIF4EBP1 and Leukemia
 Insulin Resistance Antibodies  >23 publications with EIF4EBP1 and Insulin Resistance
 Male Urogenital Diseases Antibodies  >21 publications with EIF4EBP1 and Male Urogenital Diseases
 Urogenital Neoplasms Antibodies  >20 publications with EIF4EBP1 and Urogenital Neoplasms

Organs/Tissues associated with anti-EIF4EBP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >147 publications with EIF4EBP1 and Muscle
 Blood Antibodies  >91 publications with EIF4EBP1 and Blood
 Vascular Antibodies  >36 publications with EIF4EBP1 and Vascular
 Heart Antibodies  >35 publications with EIF4EBP1 and Heart
 Liver Antibodies  >33 publications with EIF4EBP1 and Liver
 Brain Antibodies  >31 publications with EIF4EBP1 and Brain
 Kidney Antibodies  >28 publications with EIF4EBP1 and Kidney
 Lung Antibodies  >27 publications with EIF4EBP1 and Lung
 Pancreas Antibodies  >19 publications with EIF4EBP1 and Pancreas
 Prostate Antibodies  >13 publications with EIF4EBP1 and Prostate
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